短纯音诱发的听性脑干反应测试中声诱发短潜伏期负反应研究

目的 总结在有听力损失儿童中行短纯音诱发的听性脑干反应(tbABR)测试时记录到的声诱发短潜伏期负反应(acoustically short latency negative response,ASNR)的特点.方法 在有听力损失的0～6岁儿童中应用SmartEP听觉诱发电位仪记录短声和短纯音ABR的反应阈,在记录到ASNR的受试者中分析其反应阈和潜伏期.结果 在所有80受试耳中共7耳(8.75%)在cABR测试中引出ASNR,40耳(50%)在tbABR测试中引出ASNR,其中1 kHz引出率最高(37耳,46.25%),2 kHz次之(25耳,31.25%).引出ASNR者ABR波V反应阈最低65 dB nHL,ASNR反应阈最低80 dB nHL.0.5、1、2和4 kHz短纯音诱发的ASNR潜伏期分别为6～8、5～7、3～5、3～4 ms.随刺激强度的增加,其潜伏期缩短.结论 有听力损失的儿童tbABR测试中可以记录到AS-NR,但不影响以波V反应阈评估听力.     

HIV感染者神经认知障碍相关血液生物标志物研究

生物标志物辅助识别HIV感染者中神经认知障碍,尤其是血液中的生物标志物,凭借其操作简单、成本低、易于接受等特点,已成为更有前景的研究方向。本文系统检索了PubMed、中国知网、万方和维普数据库2008－2017年有关HIV感染者神经认知障碍的血液生物标志物研究文献,结合手工引文追溯检索到与纳入排除标准相符合的文献2篇,共纳入43篇相关文献进行系统综述,以期为深入研究和临床应用提供科学参考。     

Typical pharmaceutical molecule removal behavior from water by positively and negatively charged composite hollow fiber nanofiltration membranes

The rejection behaviors of two different charged composite hollow fiber nanofiltration (NF) membranes for six pharmaceutical molecules, primidone, carbamazepine, sulfamethoxazole, atenolol, sulfadimidine and norfloxacin, were characterized in this study. The saturation adsorption behaviors of the different pharmaceutical molecules on each membrane surface were studied and found to be related to the molecular weight, charge and hydrophilicity of the pharmaceutical molecules. After the pharmaceutical molecules reached adsorption equilibrium, the rejection rates of different NF membranes were characterized. The rejection rates of primidone, carbamazepine, sulfamethoxazole, atenolol, sulfadimidine and norfloxacin by the PEI-NF membrane were 85.6%, 91.8%, 79.9%, 98.1%, 93.3%, and 97.1%, respectively. Meanwhile, the rejection rates of the pharmaceutical molecules by the PIP-NF membrane were 82.2%, 85.4%, 91.5%, 79.1%, 87% and 93.3%, respectively. The influence of feed concentration, operation pressure, temperature, pH and ionic strength on the rejection behaviors of the different charged NF membranes were also studied.

The rejection behaviors of two different charged composite hollow fiber nanofiltration (NF) membranes for six pharmaceutical molecules, primidone, carbamazepine, sulfamethoxazole, atenolol, sulfadimidine and norfloxacin, were characterized in this study.     

Exploratory development of PCR-fluorescent probes in rapid detection of mutations associated with extensively drug-resistant tuberculosis

European Journal of Clinical Microbiology & Infectious Diseases - This study aims to evaluate the clinical value of PCR-fluorescent probes for detecting the mutation gene associated with...     

Decreased cortical thickness of left premotor cortex as a treatment predictor in major depressive disorder

Brain Imaging and Behavior - This study aimed to examine the cerebral cortex characteristics (thickness, surface area, and curvature) in patients with major depressive disorder (MDD), and explore...     

A mitochondrial-targetable dual functional near-infrared fluorescent probe to monitor pH and H2O2 in living cells and mice

A lower pH level and high hydrogen peroxide (H₂O₂) concentration in mitochondria is closely associated with a variety of diseases including cancer and inflammation. Thus, determination of changes in the level of acidic pH and H₂O₂ is of great importance and could provide new insights into the key functions under both physiological and pathological conditions. Herein, we present a novel mitochondria-targetable probe NIR-pH-H₂O₂, as the first near infrared (NIR) fluorescent small molecule, to monitor changes of endogenous pH (pk_a = 6.17) and H₂O₂ with high sensitivity, good compatibility and low cytotoxicity. Futhermore, it was successfully employed to monitor pH and H₂O₂ in a mouse acute inflammation model. These results demonstrate that NIR-pH-H₂O₂ is a novel bifunctional mitochondrial-targeted NIR probe to sense acidic pH and H₂O₂in vitro and in vivo, indicating its huge potential for the diagnosis of pH and H₂O₂-related diseases.

A lower pH level and high hydrogen peroxide (H₂O₂) concentration in mitochondria is closely associated with a variety of diseases including cancer and inflammation.     

热敏灸结合等速肌力训练改善肱骨外科颈骨折术后患者肩关节功能的临床效果研究

目的:比较热敏灸结合等速肌力训练与常规运动疗法对肱骨外科颈骨折术后肩关节功能康复的疗效.方法:将62例单侧肱骨外科颈骨折术后患者随机分为对照组(32例)和治疗组(30例).对照组采取基础药物与常规运动物理疗法,进行先被动、后主动的肩关节训练模式;治疗组对患肢处阿是穴、颈夹脊穴、风门、手三里、肩髃、肩髂、肩贞、肩前等进行腧穴热敏定性探测,后对热敏部位施以温和灸,同时进行等速肌力训练.2组治疗周期均为4周.分别于治疗前、治疗中(2周)及治疗后评价患者VAS评分、Constant评分,并在整个治疗过程中统计术后并发症发生率.结果:与治疗前相比,2组在治疗中及治疗后,VAS评分均降低、Constant评分均升高,治疗组的改善程度优于对照组,差异均有统计学意义;治疗后与治疗中比较,温针灸组VAS评分降低、Constant评分升高,对照组VAS评分降低,差异均有统计学意义.结论:热敏灸疗法有助于进一步提高肱骨外科颈骨折术后肩关节功能康复效果.     

甲状舌管癌的临床特征

目的:总结甲状舌管癌的临床特征及治疗方法。方法:回顾性分析北京协和医院收治的160例甲状舌管病变患者的临床资料,并检索相关文献。结果:160例患者中,甲状舌管癌3例(1.88%)。3例均采取手术治疗彻底切除病变,术后病理确诊为甲状舌管乳头状癌。其中1例伴有颈部淋巴结肿大,同期行颈淋巴清扫术并证实为转移癌,术后采用I131治疗。分别随访2、10和14年未见复发或转移。结论:甲状舌管癌发病率极低,诊断需通过病理检查明确,治疗原则首选手术切除,必要时同期行颈淋巴清扫术。