全文获取类型
收费全文 | 3370篇 |
免费 | 153篇 |
国内免费 | 21篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 64篇 |
妇产科学 | 57篇 |
基础医学 | 462篇 |
口腔科学 | 150篇 |
临床医学 | 193篇 |
内科学 | 895篇 |
皮肤病学 | 23篇 |
神经病学 | 154篇 |
特种医学 | 92篇 |
外科学 | 736篇 |
综合类 | 10篇 |
预防医学 | 53篇 |
眼科学 | 53篇 |
药学 | 191篇 |
中国医学 | 7篇 |
肿瘤学 | 394篇 |
出版年
2024年 | 3篇 |
2023年 | 14篇 |
2022年 | 29篇 |
2021年 | 70篇 |
2020年 | 26篇 |
2019年 | 52篇 |
2018年 | 76篇 |
2017年 | 54篇 |
2016年 | 76篇 |
2015年 | 77篇 |
2014年 | 111篇 |
2013年 | 139篇 |
2012年 | 208篇 |
2011年 | 236篇 |
2010年 | 155篇 |
2009年 | 115篇 |
2008年 | 224篇 |
2007年 | 213篇 |
2006年 | 221篇 |
2005年 | 223篇 |
2004年 | 236篇 |
2003年 | 238篇 |
2002年 | 207篇 |
2001年 | 47篇 |
2000年 | 33篇 |
1999年 | 39篇 |
1998年 | 46篇 |
1997年 | 32篇 |
1996年 | 42篇 |
1995年 | 30篇 |
1994年 | 36篇 |
1993年 | 20篇 |
1992年 | 17篇 |
1991年 | 19篇 |
1990年 | 17篇 |
1989年 | 21篇 |
1988年 | 20篇 |
1987年 | 10篇 |
1986年 | 12篇 |
1985年 | 9篇 |
1984年 | 12篇 |
1983年 | 11篇 |
1982年 | 16篇 |
1981年 | 6篇 |
1980年 | 12篇 |
1979年 | 5篇 |
1978年 | 4篇 |
1976年 | 3篇 |
1973年 | 5篇 |
1969年 | 4篇 |
排序方式: 共有3544条查询结果,搜索用时 31 毫秒
101.
102.
Akemi Tsutsui Yoshimi Bando Yasunori Sato Hidenori Miyake Seiko Sawada-Kitamura Hiroshi Shibata Yuko Kakuda Kenichi Harada Motoko Sasaki Yasuni Nakanuma 《Clinical journal of gastroenterology》2014,7(5):441-448
Biliary adenofibroma (BAF) is a rare, benign liver tumor. Herein, we report a case of BAF with histological features of imminent malignant changes. Ultrasound and CT revealed a solid 2.5-cm mass in the right liver lobe. The patient was asymptomatic and had no past medical history including liver disease. A general examination that included the abdomen and the laboratory data were normal. Because of the increase of its size, this tumor was surgically resected. Grossly, a 3.5-cm nodular mass abutted on the hepatic capsule was found, and its cut surface showed a well-circumscribed, whitish, and firm lesion that showed microcystic changes in the periphery and solid changes in the central parts. Histologically, the tumor showed a proliferation of tubulocystic structures embedded in a fibrous stroma. Microcysts were prevalent in the periphery, while tubular components with abundant fibrous stroma were in the central parts. The tubules were variably dilated and branched. This case closely resembled the previously reported cases of BAF, except that there were complicated papillary projections with fine fibrovascular cores in some of the microcysts and that the epithelial component in papillary projections showed dysplastic changes and increased cellular proliferative activities, implicating ominous features of imminent malignant changes. These dysplastic and papillary changes may be an intermediate lesion leading to malignancy, which have occasionally been reported in BAF. 相似文献
103.
104.
105.
106.
107.
108.
109.
Ikiru Atsuta Yasunori Ayukawa Takayoshi Yamaza Akihiro Furuhashi Kiyoshi Koyano 《Archives of oral biology》2013
Background
Oral epithelial cells (OECs) adhesion to titanium may improve the success rate of implant restoration.Purpose
We investigated the mechanism by which OECs adhere to titanium dental implants.Materials and methods
(1) After culturing rat OECs on titanium plates (Ti) or culture dishes in the presence or absence of a phosphoinositide 3-kinase (PI3K) activator or inhibitors and/or growth factors, and OEC morphology under these conditions were analyzed. (2) Right maxillary first molars were extracted and replaced with experimental implants. The rats were treated with or without growth factors.Results
(1) Cell adherence was lower of OECs on Ti than in those on culture dishes, as were the levels of integrin β4 and the continuity of F-actin structures. After PI3K inhibition, markedly reducing adherence to both substrates. In contrast, PI3K activation with activator or insulin-like growth factor restored the OEC adherence and the expression of adhesion molecules on Ti to the levels seen in OECs cultured on dishes. Cell migration was inhibited by PI3K activation. (2) High expression of integrin β4 was observed in the peri-implant epithelia of PI3K-activated rats.Conclusion
These findings suggest that PI3K plays an important role in the adhesion of OECs to Ti. 相似文献110.
Kageyama Y Torikai E Tsujimura K Kobayashi M 《Modern rheumatology / the Japan Rheumatism Association》2012,22(1):89-93
To investigate the role of interleukin (IL)-33 in rheumatoid arthritis (RA) patients, we measured the serum levels of IL-33
in RA patients before and after the administration of etanercept. Twenty-four patients with RA were treated with etanercept.
Clinical and laboratory examinations, including serum levels of C-reactive protein (CRP) and hemoglobin (Hb); white blood
cell (WBC) and red blood cell (RBC) counts; and the Disease Activity Score of 28 joints including CRP (DAS28-CRP), were performed
at the baseline and at 3 and 6 months after the initial treatment with etanercept. The mean serum IL-33 levels had decreased
significantly at 3 and 6 months after the initial treatment with etanercept. Serum IL-33 levels showed a significant correlation
with the number of tender joints, CRP, DAS28-CRP, and the WBC count, and an inverse correlation with the RBC count and Hb
level. These findings indicated that the decrease of serum IL-33 levels was a novel function of etanercept, shown for the
first time in this study. Measurement of serum levels of IL-33 may become a useful control marker for RA treatment. 相似文献