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排序方式: 共有1444条查询结果,搜索用时 203 毫秒
51.
52.
Akari Karaiwa Sohei Yamada Hodaka Yamamoto Mizuho Wakasa Hannosuke Ishijima Ryutaro Akiyama Yoichiroh Hosokawa Yasumasa Bessho Takaaki Matsui 《Genes to cells : devoted to molecular & cellular mechanisms》2020,25(8):582-592
Collective cell migration, in which cells assemble and move together, is an essential process in embryonic development, wound healing and cancer metastasis. Chemokine signaling guides cell assemblies to their destinations. In zebrafish posterior lateral line primordium (PLLP), a model system for collective cell migration, it has been proposed that the chemokine ligand Cxcl12a secreted from muscle pioneer cells (MPs) and muscle fast fibers (MFFs), which are distributed along with the horizontal midline, binds to the receptor Cxcr4b in PLLP and that Cxcl12a–Cxcr4b signaling guides the anterior‐to‐posterior migration of PLLP along the horizontal midline. However, how the surrounding tissues affect PLLP migration remains to be elucidated. Here, we investigated the relationship between the PLLP and the surrounding tissues and found that a furrow between the dorsal and ventral myotomes is generated by Sonic hedgehog (Shh) signaling‐dependent MP and MFF differentiation and that the PLLP migrates in this furrow. When transient inhibition of Shh signaling impaired both the furrow formation and differentiation of cxcl12a‐expressing MPs/MFFs, directional PLLP migration was severely perturbed. Furthermore, when differentiated MPs and MFFs were ablated by femtosecond laser irradiations, the furrow remained and PLLP migration was relatively unaffected. These results suggest that the furrow formation between the dorsal and ventral myotomes is associated with the migratory behavior of PLLP. 相似文献
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Yasumasa Eguchi Manabu Jinde Kazuki Murooka Yoshimasa Konno Masanori Ohta Hiroshi Yamato 《European journal of applied physiology》2014,114(12):2617-2623
Purpose
Effective recovery from muscle fatigue, especially during rest intervals between periods of high-intensity activity, is important to ensure optimal subsequent performance. Stretching and icing are two types of treatment used for muscle recovery in such situations. However, their effectiveness remains unclear because of a lack of adequate evidence and/or discrepant results of previous studies. We performed a study to elucidate the effects of stretching and icing on muscle fatigue in subjects performing alternating muscle contraction and rest.Methods
Sixteen healthy male subjects aged 21–27 years were evaluated. Each subject performed repeated isometric muscle contraction exercises that involved lifting and holding a dumbbell to induce muscle fatigue. Four treatments were performed during the rest periods between isometric muscle contraction: static stretching, ballistic stretching, no stretching, or icing. Electromyography and relative muscle oxygen saturation measurements were performed during the exercises. Muscle fatigue was indirectly estimated by the decline in the median frequency of the electromyographic signal.Results
Stretching between alternate isometric muscle contraction exercises resulted in a significantly lower median frequency of the electromyographic signal than did no stretching. There was no significant difference in the change in the median frequency between static and ballistic stretching. Conversely, icing between alternate exercises did not decrease the median frequency.Conclusions
Stretching, whether static or ballistic, is not beneficial for recovery from muscle fatigue and may actually inhibit recovery. Icing may more effectively induce such recovery and thus may be a better choice between the two treatment techniques. 相似文献55.
56.
Yasumasa Ito Yukihide Iwamoto Kazuhiro Tanaka Kiyotaka Okuyama Yoichi Sugioka 《International journal of cancer. Journal international du cancer》1996,67(1):148-152
We describe a quantitative assay for assessing tumor angiogenesis in vivo using basement membrane extracts (Matrigel). Nude mice were injected s.c. with liquid Matrigel mixed with HT1080 human fibrosarcoma cells. Since Matrigel rapidly forms a solid gel at body temperature, the gel containing tumor cells can be removed immediately and then processed for histological studies. Tumor angiogenesis was monitored quantitatively by measuring both the number and the total area of neovessels present in the gels using an image analyzer, which could be achieved approximately 72 hr later. Furthermore, HT1080 cell-conditioned medium, which may contain various tumor-derived factors, promoted the basement membrane degradation, migration, proliferation and tube formation of endothelial cells in vitro, as did Matrigel, although to a lesser extent. In addition, Northern blot analysis demonstrated that the amount of vascular endothelial growth factor (VEGF) mRNA in HT1080 cells was much higher than that in human fibroblasts or NIH3T3 cells. Our results suggest that angiogenesis observed in our assay may be due to the synergic effects of tumor angiogenic factors such as VEGF, and Matrigel. The advantages of our assay are: 1) it is possible to assess early angiogenesis quantitatively; and 2) this assay may be applicable for screening anti-angiogenic therapeutic agents to be used against human neoplasms. © 1996 Wiley-Liss, Inc. 相似文献
57.
Abe Takashi Yabuuchi Akiko Ezoe Kenji Skaletsky Helen Fukuda Junichiro Ueno Satoshi Fan Yuting Goldsmith Sierra Kobayashi Tamotsu Silber Sherman Kato Keiichi 《Journal of assisted reproduction and genetics》2020,37(2):297-304
Journal of Assisted Reproduction and Genetics - To determine age-adjusted overall success rates for patients undergoing clomiphene citrate only minimal stimulation cycle (mini) in vitro... 相似文献
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59.
Eriko Yanagida Hiroaki Miyoshi Mai Takeuchi Noriaki Yoshida Kazutaka Nakashima Kyohei Yamada Takeshi Umeno Yasumasa Shimasaki Takuya Furuta Masao Seto Koichi Ohshima 《Hematological oncology》2020,38(5):680-688
The interaction of CD47 and signal-regulatory protein alpha (SIRPα) induces “don't eat me signal”, leading suppression of phagocytosis. This signal can affect the clinical course of malignant disease. Although CD47 and SIRPα expression are associated with clinicopathological features in several neoplasms, the investigation for adult T-cell leukemia/lymphoma (ATLL) has not been well-documented. This study aimed to declare the association between CD47 and SIRPα expression and clinicopathological features in ATLL. We performed immunostaining on 73 biopsy samples and found that CD47 is primarily expressed in tumor cells, while SIRPα is expressed in non-neoplastic stromal cells. CD47 positive cases showed significantly higher FoxP3 (P = .0232) and lower CCR4 (P = .0214). SIRPα positive cases presented significantly better overall survival than SIRPα negative cases (P = .0132). SIRPα positive cases showed significantly HLA class I (P = .0062), HLA class II (P = .0133), microenvironment PD-L1 (miPD-L1) (P = .0032), and FoxP3 (P = .0229) positivity. In univariate analysis, SIRPα expression was significantly related to prognosis (Hazard ratio [HR] 0.470; 95% confidence interval [CI] 0.253-0.870; P = .0167], although multivariate analysis did not show SIPRα as an independent prognostic factor. The expression of SIRPα on stromal cells reflects activated immune surveillance mechanism in tumor microenvironment and induce good prognosis in ATLL. More detailed studies for gene expression or genomic abnormalities will disclose clinical and biological significance of the CD47 and SIRPα in ATLL. 相似文献
60.
Analysis of oxidative stress expressed by urinary level of biopyrrins and 8‐hydroxydeoxyguanosine in patients with chronic schizophrenia
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Tsuyoshi Miyaoka MD PhD Masa Ieda MD PhD Sadayuki Hashioka MD PhD Rei Wake MD PhD Motohide Furuya MD PhD Kristian Liaury MD PhD Maiko Hayashida MD PhD Keiko Tsuchie PhD Ryosuke Arauchi PhD Tomoko Araki PhD Izuru Shioji PhD Satoko Ezoe PhD Ken Inoue MD PhD Tokio Yamaguchi PhD Jun Horiguchi MD PhD 《Psychiatry and clinical neurosciences》2015,69(11):693-698