全文获取类型
收费全文 | 1392篇 |
免费 | 37篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 21篇 |
妇产科学 | 15篇 |
基础医学 | 140篇 |
口腔科学 | 43篇 |
临床医学 | 74篇 |
内科学 | 313篇 |
皮肤病学 | 30篇 |
神经病学 | 211篇 |
特种医学 | 47篇 |
外科学 | 217篇 |
综合类 | 4篇 |
预防医学 | 27篇 |
眼科学 | 21篇 |
药学 | 82篇 |
中国医学 | 4篇 |
肿瘤学 | 190篇 |
出版年
2023年 | 7篇 |
2022年 | 21篇 |
2021年 | 29篇 |
2020年 | 26篇 |
2019年 | 23篇 |
2018年 | 24篇 |
2017年 | 18篇 |
2016年 | 28篇 |
2015年 | 26篇 |
2014年 | 31篇 |
2013年 | 36篇 |
2012年 | 96篇 |
2011年 | 124篇 |
2010年 | 55篇 |
2009年 | 52篇 |
2008年 | 90篇 |
2007年 | 83篇 |
2006年 | 88篇 |
2005年 | 73篇 |
2004年 | 96篇 |
2003年 | 83篇 |
2002年 | 74篇 |
2001年 | 14篇 |
2000年 | 16篇 |
1999年 | 19篇 |
1998年 | 17篇 |
1997年 | 14篇 |
1996年 | 21篇 |
1995年 | 19篇 |
1994年 | 18篇 |
1993年 | 19篇 |
1992年 | 6篇 |
1991年 | 11篇 |
1990年 | 9篇 |
1989年 | 8篇 |
1988年 | 5篇 |
1987年 | 6篇 |
1986年 | 2篇 |
1985年 | 6篇 |
1984年 | 7篇 |
1982年 | 5篇 |
1981年 | 11篇 |
1980年 | 4篇 |
1979年 | 2篇 |
1978年 | 3篇 |
1977年 | 3篇 |
1975年 | 2篇 |
1970年 | 3篇 |
1968年 | 2篇 |
1967年 | 2篇 |
排序方式: 共有1444条查询结果,搜索用时 15 毫秒
21.
22.
23.
24.
Yagi S Aihara K Ikeda Y Sumitomo Y Yoshida S Ise T Iwase T Ishikawa K Azuma H Akaike M Matsumoto T 《Circulation research》2008,102(1):68-76
Angiotensin II (Ang II) plays a pivotal role in cardiovascular remodeling leading to hypertension, myocardial infarction, and stroke. Pitavastatin, an HMG-CoA reductase inihibitor, is known to have pleiotropic actions against the development of cardiovascular remodeling. The objectives of this study were to clarify the beneficial effects as well as the mechanism of action of pitavastatin against Ang II-induced organ damage. C57BL6/J mice at 10 weeks of age were infused with Ang II for 2 weeks and were simultaneously administered pitavastatin or a vehicle. Pitavastatin treatment improved Ang II-induced left ventricular hypertrophy and diastolic dysfunction and attenuated enhancement of cardiac fibrosis, cardiomyocyte hypertrophy, coronary perivascular fibrosis, and medial thickening. Ang II-induced oxidative stress, cardiac TGFbeta-1 expression, and Smad 2/3 phosphorylation were all attenuated by pitavastatin treatment. Pitavastatin also reduced Ang II-induced cardiac remodeling and diastolic dysfunction in eNOS-/- mice as in wild-type mice. In eNOS-/- mice, the Ang II-induced cardiac oxidative stress and TGF-beta-Smad 2/3 signaling pathway were enhanced, and pitavastatin treatment attenuated the enhanced oxidative stress and the signaling pathway. Moreover, pitavastatin treatment reduced the high mortality rate and improved renal insufficiency in Ang II-treated eNOS-/- mice, with suppression of glomerular oxidative stress and TGF-beta-Smad 2/3 signaling pathway. In conclusion, pitavastatin exerts eNOS-independent protective actions against Ang II-induced cardiovascular remodeling and renal insufficiency through inhibition of the TGF-beta-Smad 2/3 signaling pathway by suppression of oxidative stress. 相似文献
25.
Shiraishi H Ishibashi K Urao N Hyogo M Tsukamoto M Keira N Hirasaki S Seo Y Shirayama T Nakagawa M 《Internal medicine (Tokyo, Japan)》2002,41(6):445-448
Verapamil is widely used for the termination of paroxysmal supraventricular tachycardia (PSVT) with little proarrhythmic effect. We describe two cases of PSVT that changed to non-sustained polymorphic ventricular tachycardia after administration of verapamil. Electrophysiological study revealed atrioventricular nodal reentrant tachycardia in the first case, and atrioventricular reentrant tachycardia due to a concealed left lateral accessory pathway in the second case. Catecholamine-induced automaticity was one of the possible mechanisms of VT in the first case, but the mechanism is unknown in the second case. 相似文献
26.
Hiroaki Yoshikane Takio Yokoi Hitoshi Hidano Akira Sakakibara Yasumasa Niwa Hidemi Goto 《Journal of gastroenterology》1997,32(6):812-816
A 51-year-old man had a reddish flat granular lesion in the stomach on endoscopic examination. Histology of biopsied specimen confirmed the diagnosis of low-grade B-cell gastric lymphoma of mucosaassociated lymphoid tissue (gastric MALT lymphoma) and simultaneous infection withHelicobacter pylori. He was given antibiotic treatment. Five weeks later, endoscopy and histology of biopsied specimen showed eradication ofH. pylori, and the tumor had regressed. Six months later,H. pylori reemerged, but the tumor had not recurred. After the second antibiotic therapy,H. pylori has been eradicated. The lymphoma has been in remission for 14 months. 相似文献
27.
28.
29.
Yagi S Akaike M Fujimura M Ise T Yoshida S Sumitomo Y Ikeda Y Iwase T Aihara K Azuma H Kurushima A Ichikawa Y Kitagawa T Kimura T Nishiuchi T Matsumoto T 《Internal medicine (Tokyo, Japan)》2008,47(12):1113-1116
Lactobacillus (LB) is a gram-positive rod-shaped bacterium that inhabits the oral cavity, gastrointestinal tract, vagina and nasal cavity. Although LB plays a role in the prevention of infections caused by pathogenic bacteria, it causes some critical infectious diseases such as infective endocarditis (IE). IE due to LB is rare; however, early diagnosis and early treatment are important because of its high mortality rate. We report the onset of IE after otologic treatment in a heavy drinker of alcohol, the second case of IE due to LB in Japan. 相似文献
30.
T. Setoyma S. Miyamoto T. Horimatsu S. Morita Y. Ezoe M. Muto G. Watanabe E. Tanaka T. Chiba 《Diseases of the esophagus》2014,27(2):112-115
The usefulness of a covered self‐expandable metallic stent for benign esophageal stricture and perforation was well established. In case of benign disease, early stent removal was recommended within 6–8 weeks after placement. A case with severe esophageal stricture caused by incomplete stent removal 7 years after stent placement for spontaneous esophageal rupture was reported. Residual stent fragments could be removed by step‐by‐step multimodal endoscopic treatment, producing satisfactory luminal diameter of the esophagus. In particular, stent trimming with argon plasma coagulation was safe and effective strategy. The endoscopic stent removal is minimally invasive and should be attempted before surgical intervention; however, it is most important to ensure early stent removal before tissue ingrowth or overgrowth can develop. 相似文献