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排序方式: 共有2341条查询结果,搜索用时 15 毫秒
21.
Morishita E Sekiya A Hayashi T Kadohira Y Maekawa M Yamazaki M Asakura H Nakao S Ohtake S 《International journal of hematology》2008,88(3):272-277
Previous studies have found markedly elevated serum concentrations of proinflammatory cytokines in patients with Graves’ disease
(GD). We investigated the role of macrophage colony-stimulating factor (M-CSF) in GD. We assayed concentrations of M-CSF in
sera from 32 patients with GD (25 untreated; 7 receiving thiamazole therapy). We also studied 32 age-matched healthy subjects
as controls. Relationships between serum M-CSF and both thyroid state and serum lipids were examined. Moreover, to examine
the effect of thyroid hormone alone on serum M-CSF, T3 was administered orally to normal subjects. Serum concentrations of
M-CSF in GD patients who were hyperthyroid were significantly increased compared with GD patients who were euthyroid (P < 0.05) and control subjects (P < 0.0001). Serum M-CSF concentrations correlated closely with T3 levels in patients (r = 0.51, P < 0.005). Serial measurement of five individual patients revealed that serum concentrations of M-CSF were significantly decreased
(P < 0.05), reaching normal control values upon attainment of euthyroidism. Furthermore, oral T3 administered to 15 volunteers
for 7 days produced significant increases in serum levels of M-CSF (P < 0.05). The close correlation between serum M-CSF and serum thyroid hormone levels suggests that high circulating levels
of thyroid hormones may directly or indirectly potentiate the production of M-CSF in patients with GD. 相似文献
22.
Nobuyuki Kamio Isao Kobayashi Masatomo Mori Teruo Uehara Hitoshi Fukuda Kazutoshi Tsuyusaki Yasuko Nakamua Setsuo Kobayashi 《Metabolism: clinical and experimental》1977,26(3):295-299
Serial measurements of serum triiodothyronine (T3), thyroxine (T4), thyrotropin (TSH), and 4-hr thyroidal 131I uptake were carried out in nine patients with subacute thyroiditis. In the acute phase, suppressed TSH and 131I uptake were observed simultaneously with the elevations of T3 and T4. Thyrotropin-releasing hormone (TRH) failed to increase TSH in all patients studied. The mean value of an increment in serum TSH was only 1.8 μU/ml during the recovery phase when 131I uptake was normal or hyper-normal. In addition, and elevated 131I uptake was not necessarily associated with an immediate increase in the serum T3 and T4. These observations suggest that the resumption of the iodide pump may be more important than an increment in TSH in producing normal or hypernormal 131I uptake during the recovery phase. There appears to be a dissociation between the reestablishment of 131I uptake and the resumption of the mechanism of hormonal synthesis and secretion in the thyroid. 相似文献
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24.
Morimasa Sekiguchi Yuzo Fujii Atsuko Saito Toshimitsu Suzuki Yasuko Shiroko Hisayoshi Nakamura Ken-ichiro Hasumi 《Journal of gastroenterology》1995,30(5):589-598
We describe a gastric carcinoma cell line that has been maintained in vitro for more than 10 years and retains the capacity
to produce a large amount of alpha-fetoprotein. This cell line was isolated from a metastatic lymph node of a 63-year-old
male patient with advanced gastric carcinoma (T2N3P0H0M0) who showed high serum levels of alpha-fetoprotein. The primary tumor
was moderately differentiated tubular adenocarcinoma and the lymph node was poorly differentiated adenocarcinoma without any
particular pattern. The cultured cells grew as densely packed islet-like colonies with small polygonal cells. Electron microscopy
revealed cells abundant in cytoplasmic organelles, with some cellular attachments being tight with junctional complexes and
some being loose across intercellular spaces. The free cell surface had microvilli. The population doubling-time was 152 h
at passage 58. Chromosomal analysis revealed the modal number to be 77, with numerous karyotype abnormalities. The tumorigenicity
of the cultured cells in athymic nude mice was positive only when they were subcutaneously transplanted beneath a plastic
plate, but when the cells were transplanted subcutaneously or administered by intrasplenic injection in intact or weakly irradiated
nude mice, no tumorigenicty was shown. The cell line produced tumor-associated antigens, such as alpha-fetoprotein, carcinoembryonic
antigen, and tissue polypeptide antigen. This cell line may be useful for comparative studies of different types of gastric
carcinoma and alpha-fetoproteins of different origins. 相似文献
25.
J. P. Palmer T. J. Wilkin A. B. Kurtz E. Bonifacio A. Arnaiz-Villena J. Barbosa D. Becker M. Codina B. Dean G. S. Eisenbarth R. Gomis F. Gorus A. Hubinger J. Karjalainen R. Kietsch-Engel B. Kuglin R. C. McEvoy J. L. Molenaar W. G. Reeves S. Soeldner Y. Uchigata R. Zanchetta 《Diabetologia》1990,33(1):60-61
26.
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28.
Genshi Egusa Fumiyo Murakami Chikako Ito Yasuko Matsumoto Seijiro Kado Midori Okamura Hiroshi Mori Kiminori Yamane Hitoshi Hara Michio Yamakido 《Atherosclerosis》1993,100(2):249-255
To investigate the association of westernized food habits and concentrations of serum lipids in the Japanese, we studied 1200 healthy Japanese living in Hiroshima prefecture and 1483 ethnic Japanese from Hiroshima prefecture living in the Hawaii Islands and Los Angeles. The nutritional assessments were made by the same dietitians. No major difference was observed in the total energy intake between the Japanese and the Japanese-Americans in both males and females. However, the intake of animal fat and simple carbohydrates (especially fructose) were markedly greater, and that of complex carbohydrates lower, in the Japanese-Americans compared with the Japanese. The mean serum cholesterol (CH), LDL-CH and serum triglyceride (TG) levels were significantly higher in the Japanese-Americans in both sexes. The mean HDL-CH concentration was similar between the two groups in males, but it was approximately 7 mg/dl higher in Japanese-American females. Using the 75 percentile values of CH and TG in the Japanese in Hiroshima, the frequency of WHO types IIa and IIb hyperlipidemia was about twice as high in the Japanese-Americans. These results suggest that westernized food habits in the Japanese include qualitative changes in animal fat, simple carbohydrate and complex carbohydrate diet rather than an increase in the total energy intake. These changes are associated with marked increases in the concentrations of serum CH and TG and increased prevalence of types IIa and IIb hyperlipidemia. 相似文献
29.
Tsutsumi YM Horikawa YT Jennings MM Kidd MW Niesman IR Yokoyama U Head BP Hagiwara Y Ishikawa Y Miyanohara A Patel PM Insel PA Patel HH Roth DM 《Circulation》2008,118(19):1979-1988
30.
Mizuki Sone Takeshi Toyoda Young‐Man Cho Jun‐ichi Akagi Kohei Matsushita Yasuko Mizuta Tomomi Morikawa Akiyoshi Nishikawa Kumiko Ogawa 《Journal of applied toxicology : JAT》2019,39(6):868-876
Phosphorylated histone H2AX (γ‐H2AX) has been demonstrated as a DNA damage marker both in vitro and in vivo. We previously reported the effects of genotoxic carcinogens in the urinary bladder of rats by immunohistochemical analysis of γ‐H2AX using samples from 28‐day repeated‐dose tests. To evaluate the application of γ‐H2AX as a biomarker of carcinogenicity in the bladder, we examined species differences in γ‐H2AX formation in the urinary bladder of mice. Six‐week‐old male B6C3F1 mice were treated orally with 12 chemicals for 4 weeks. Immunohistochemical analysis demonstrated that N‐butyl‐N‐(4‐hydroxybutyl)nitrosamine, p‐cresidine and 2‐acetylaminofluorene (2‐AAF), classified as genotoxic bladder carcinogens, induced significant increases in γ‐H2AX levels in the bladder urothelium. In contrast, genotoxic (2‐nitroanisole, glycidol, N‐nitrosodiethylamine and acrylamide) and non‐genotoxic (dimethylarsinic acid and melamine) non‐bladder carcinogens did not upregulate γ‐H2AX. Importantly, 2‐nitroanisole, a potent genotoxic bladder carcinogen in rats, significantly increased the proportion of γ‐H2AX‐positive cells in rats only, reflecting differences in carcinogenicity in the urinary bladder between rats and mice. Significant upregulation of γ‐H2AX was also induced by uracil, a non‐genotoxic bladder carcinogen that may be associated with cell proliferation, as demonstrated by increased Ki67 expression. 2‐AAF caused γ‐H2AX formation mainly in the superficial layer, together with reduced and disorganized expression of uroplakin III, unlike in rats, suggesting the mouse‐specific cytotoxicity of 2‐AAF in umbrella cells. These results suggest γ‐H2AX is a useful biomarker reflecting species differences in carcinogenicity in the urinary bladder. 相似文献