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Novel image monitoring system using a head‐mounted display for assistants in da Vinci surgery
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Do testosterone levels have prognostic significance in patients with metastatic prostate cancer treated with combined androgen blockade?
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A Novel Approach to Patient Self‐Monitoring of Sonographic Examinations Using a Head‐Mounted Display
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Identification and functional characterization of a sex pheromone receptor in the silkmoth Bombyx mori 总被引:7,自引:0,他引:7
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Sakurai T Nakagawa T Mitsuno H Mori H Endo Y Tanoue S Yasukochi Y Touhara K Nishioka T 《Proceedings of the National Academy of Sciences of the United States of America》2004,101(47):16653-16658
Sex pheromones released by female moths are detected with high specificity and sensitivity in the olfactory sensilla of antennae of conspecific males. Bombykol in the silkmoth Bombyx mori was the first sex pheromone to be identified. Here we identify a male-specific G protein-coupled olfactory receptor gene, B. mori olfactory receptor 1 (BmOR-1), that appears to encode a bombykol receptor. The BmOR-1 gene is located on the Z sex chromosome, has an eight-exon/seven-intron structure, and exhibits male-specific expression in the pheromone receptor neurons of male moth antenna during late pupal and adult stages. Bombykol stimulation of Xenopus laevis oocytes expressing BmOR-1 and BmGalphaq elicited robust dose-dependent inward currents on two-electrode voltage clamp recordings, demonstrating that the binding of bombykol to BmOR-1 leads to the activation of a BmGalphaq-mediated signaling cascade. Antennae of female moths infected with BmOR-1-recombinant baculovirus showed electrophysiological responses to bombykol but not to bombykal. These results provide evidence that BmOR-1 is a G protein-coupled sex pheromone receptor that recognizes bombykol. 相似文献
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Norihiro Sato Kei Yabuki Kazunori Shibao Yasuhisa Mori Toshihisa Tamura Aiichiro Higure Koji Yamaguchi 《HPB : the official journal of the International Hepato Pancreato Biliary Association》2014,16(2):177-182
Background: A prolonged operative time is associated with adverse post-operative outcomes in laparoscopic surgery. Although a single-incision laparoscopic cholecystectomy (SILC) requires a longer operative time as compared with a conventional laparoscopic cholecystectomy, risk factors for a prolonged operative time in SILC remain unknown.Methods: A total of 20 clinical variables were retrospectively reviewed to identify factors for a prolonged operative time (longer than 3 h) in a total of 220 consecutive patients undergoing SILC.Results: The median operative time was 145 min (range, 55–435) and a prolonged operative time was required in 62 patients (28%). Independent factors that predict a prolonged operative time as identified through multivariate analysis were body mass index (BMI) (P = 0.009), acute cholecystitis (P < 0.001) and operator (resident or staff surgeon) (P < 0.001). Furthermore, a prolonged operative time was significantly associated with an increased amount of intra-operative blood loss (P < 0.001) and a prolonged stay after surgery (P < 0.001).Conclusions: These findings suggest that a higher BMI, acute cholecystitis and a resident as an operator significantly increase the duration of SILC procedures. 相似文献
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