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21.
Leila R. Martins Yasser Perera Paulo Lúcio Maria G. Silva Silvio E. Perea Jo?o T. Barata 《Oncotarget》2014,5(1):258-263
Chronic lymphocytic leukemia (CLL) remains an incurable malignancy, urging for the identifcation of new molecular targets for therapeutic intervention. CLL cells rely on overexpression and hyperactivation of the ubiquitous serine/threonine protein kinase CK2 for their viability in vitro. CIGB-300 is a cell-permeable selective CK2 inhibitor peptide undergoing clinical trials for several cancers. Here, we show that CIGB-300 promotes activation of the tumor suppressor PTEN and abrogates PI3K-mediated downstream signaling in CLL cells. In accordance, CIGB-300 decreases the viability and proliferation of CLL cell lines, promotes apoptosis of primary leukemia cells and displays antitumor efcacy in a xenograft mouse model of human CLL. Our studies provide pre-clinical support for the testing and possible inclusion of CK2 inhibitors in the clinical arsenal against CLL. 相似文献
22.
Steven Kaptik Yasser Jamal Barbara Kay Jackson Claudio Tombazzi 《The American journal of the medical sciences》2010,339(1):95-97
Chronic mesenteric ischemia classically presents as “intestinal angina” with generalized postprandial abdominal pain lasting up to 3 hours. Over time, these episodes can become much more intense and ultimately lead to sitophobia with significant weight loss. Symptoms are not specific and often mistakenly attributed to other gastrointestinal etiologies such as peptic ulcer disease. Gastric ulcerations as a direct result of mesenteric ischemia have been reported but are relatively rare because of the rich collateral blood supply to the stomach. Therefore, a diagnosis of ischemic gastropathy is seldom entertained in patients presenting with abdominal pain and gastriculcers. 相似文献
23.
Yasser Mostafa Hafez Omnia Safwat El-Deeb Marwa Mohamed Atef 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):1065-1070
Background
Diabetic foot ulceration (DFU) is a serious diabetic complication that can progress to amputation and since SIRT1 regulates glucose metabolism, inflammation, and oxidative stress which are the major contributors in diabetic complications, So we aimed to discuss its role as an epigenetic biomarker in DFU and highlight its link to oxidative stress and inflammatory cytokines.Method
60 DM patients were enrolled in the study, 30 without DFU and 30 with DFU in addition to 15 healthy subjects (control group). SIRT1 mRNA relative gene expression was assessed. Catalase activity, advanced glycation end products (AGEs), tumor necrosis factor alpha (TNFα), interleukin 6 (IL-6) and High mobility group box1 (HMGB1) levels were measured. DNA fragmentation was also performed.Result
SIRT1 expression and catalase activity were significantly decreased in diabetic patients compared to control group with the lowest levels in DFU patients, TNFα, IL-6, HMGB 1 and AGEs levels were significantly higher in the diabetic patients compared to control group with the highest levels in DFU patients. DNA fragmentation was more profound in DFU patients.Conclusion
The study revealed that SIRT1 mRNA expression can be considered as a novel biomarker in DFU being a major player involved in its pathogenesis. 相似文献24.
Some limited models have been suggested to determine the conductivity of polymer carbon nanotube (CNT) nanocomposites (PCNTs). However, earlier models (e.g., the Kovacs model) cannot properly consider the roles of the interphase regions or tunneling properties on the percolation threshold and subsequent conductivity of PCNTs. In this paper, the Kovacs model is further developed by assuming that the CNT, interphase, and tunneling regions are separate phases. Also, some simple equations are provided to calculate the percolation threshold as well as the volume fractions and resistances of the CNT, interphase, and tunneling regions in conductive networks. The experimental conductivity results for several samples are compared with the predictions of the developed model. In addition, the calculations of the developed model at different parameter levels are explained and justified. The conductivity calculations show good agreement with the experimental data. Moreover, the developed model reasonably explains the roles of the different parameters on the conductivity. For example, long, thin, and straight CNTs efficiently improve the conductivity because they form large networks in the nanocomposites. Additionally, a thick interphase enlarges the conductive networks, resulting in a desirable conductivity. The conductivity of PCNTs only depends on the tunneling resistance; this is the case because the poor resistance/significant conductivity of the CNT and interphase regions do not influence the conductivity. The developed equations can replace conventional approaches for predicting the conductivity of nanocomposites.Some limited models have been suggested to determine the conductivity of polymer carbon nanotube (CNT) nanocomposites (PCNTs). 相似文献
25.
Miedany Yasser El Gaafary Maha El Toth Mathias Hegazi Mohamed Osama Aroussy Nadia El Hassan Waleed Almedany Samah Nasr Annie Bahlas Sami Galal Salwa 《Clinical rheumatology》2021,40(10):4225-4232
Clinical Rheumatology - The prevalence of sarcopenia with osteoporosis results in a higher risk of falling and fractures. It was noted that patients who had completed their planned 5-year denosumab... 相似文献
26.
Yasser Albogami Kenneth Cusi Michael J. Daniels Yu-Jung J. Wei Almut G. Winterstein 《Diabetes care》2021,44(6):1344
OBJECTIVEEmerging data from animal and human pilot studies suggest potential benefits of glucagon-like peptide 1 receptor agonists (GLP-1RA) on lung function. We aimed to assess the association of GLP-1RA and chronic lower respiratory disease (CLRD) exacerbation in a population with comorbid type 2 diabetes (T2D) and CLRD.RESEARCH DESIGN AND METHODSA new-user active-comparator analysis was conducted with use of a national claims database of beneficiaries with employer-sponsored health insurance spanning 2005–2017. We included adults with T2D and CLRD who initiated GLP-1RA or dipeptidyl peptidase 4 inhibitors (DPP-4I) as an add-on therapy to their antidiabetes regimen. The primary outcome was time to first hospital admission for CLRD. The secondary outcome was a count of any CLRD exacerbation associated with an inpatient or outpatient visit. We estimated incidence rates using inverse probability of treatment weighting for each study group and compared via risk ratios.RESULTSThe study sample consisted of 4,150 GLP-1RA and 12,540 DPP-4I new users with comorbid T2D and CLRD. The adjusted incidence rate of first CLRD admission during follow-up was 10.7 and 20.3 per 1,000 person-years for GLP-1RA and DPP-4I users, respectively, resulting in an adjusted hazard ratio of 0.52 (95% CI 0.32–0.85). For the secondary outcome, the adjusted incidence rate ratio was 0.70 (95% CI 0.57–0.87).CONCLUSIONSGLP-1RA users had fewer CLRD exacerbations in comparison with DPP-4I users. Considering both plausible mechanistic pathways and this real-world evidence, potential beneficial effects of GLP-1RA may be considered in selection of an antidiabetes treatment regimen. Randomized clinical trials are warranted to confirm our findings. 相似文献
27.
Navas-Sánchez Francisco J. Fernández-Pena Alberto Martín de Blas Daniel Alemán-Gómez Yasser Marcos-Vidal Luís Guzmán-de-Villoria Juan A. Fernández-García Pilar Romero Julia Catalina Irene Lillo Laura Muñoz-Blanco José L. Ordoñez-Ugalde Andrés Quintáns Beatriz Pardo Julio Sobrido María-Jesús Carmona Susanna Grandas Francisco Desco Manuel 《Journal of neurology》2021,268(7):2429-2440
Journal of Neurology - SPG4 is an autosomal dominant pure form of hereditary spastic paraplegia (HSP) caused by mutations in the SPAST gene. HSP is considered an upper motor neuron disorder... 相似文献
28.
Amr Salah Omar Bassam Shoman Suraj Sudarsanan Yasser Shouman 《World Journal of Virology》2021,10(3):130-136
BACKGROUNDThe coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2, represents a major challenge to health care systems both globally and regionally, with many opting by cancelling elective surgeries. Cardiac operations in patients diagnosed with COVID-19 have been imperative due to their emergency nature, critical condition of patients awaiting cardiac surgery, and accumulated number of cardiac surgical interventions throughout the last months.CASE SUMMARYHere we describe three COVID-19 positive cases who underwent coronary surgery, on an urgent basis. We did not experience worsening of the patients’ clinical condition due to COVID-19 and therefore a routine post-operative chest X-ray (CXR) was not required. None of the health care providers attending the patients endured cross infection. Further trials would be needed in order to confirm these results.CONCLUSIONWhile the pandemic has adversely hit the health systems worldwide, cardiac surgical patients who concomitantly contracted COVID-19 may undergo a smooth post-operative course as a routine post-operative CXR may not be required. 相似文献
29.
30.
Fahad S. Alshehri Yasser Alatawi Badrah S. Alghamdi Abdullah A. Alhifany Adnan Alharbi 《Saudi Pharmaceutical Journal》2020,28(12):1666-1673
BackgroundThe coronavirus diseases of 2019 (COVID-19) pandemic was classified as one of the worst pandemics in the 21st century. Its rapid transmission, unpredicted mortality rate, and the uncertainty surrounding its transmission method have evoked additional fear and anxiety. Nonetheless, to the best of our knowledge, no prior study has explored PTSD prevalence three months after the start of the quarantine procedures in Saudi Arabia nor has examined PTSD prevalence by three different methods.ObjectiveThis observational cross-sectional study aimed to identify the prevalence, severity, and influencing factors of PTSD in different regions of Saudi Arabia three months after the onset of the quarantine procedures related to the COVID-19 pandemic.MethodsThrough the month of June 2020, 1374 people (49.05% men and 50.95% women) completed a 35-item, 10-minute online. The prevalence of PTSD was measured using PCL-S (specific for COVID-19) that assesses the 17 symptoms of PTSD. Resilience was measured using 2-items Arabic version of the Connor-Davidson Resilience Scale 2 (CD-RISC 2).ResultsWe calculated the prevalence by three methods, namely, PTSD cut-off score, criteria, and combined, and the prevalence was 22.63%, 24.8%, and 19.6%, respectively. Female participants showed higher prevalence than male. As well, participants who were either tested positive or suspected of having been infected with COVID-19 showed higher PTSD prevalence. Higher resilience was associated with lower PTSD prevalence.ConclusionsThis was the first study to report PTSD prevalence by three differential methods three months after the onset of the quarantine procedures related to the COVID-19 pandemic in Saudi Arabia. We observed a significant impact of the COVID-19 pandemic in the Saudi population; therefore, great attention should be performed in implementing new procedures that deal with the highlighted risk factors, especially in vulnerable groups, to overcome the psychological impact of the COVID-19 pandemic. 相似文献