吉西他滨单药治疗老年晚期非小细胞肺癌的临床疗效分析

目的观察吉西他滨单药治疗老年晚期非小细胞肺癌的疗效及毒副作用。方法老年晚期非小细胞肺癌37例,应用吉西他滨1125mg/m2治疗,2个周期后评价疗效和毒副反应。结果总有效率为24.3%,生活质量改善12例(32.4%),主要毒副反应为骨髓抑制及消化道反应。结论吉西他滨单药治疗老年晚期非小细胞肺癌疗效肯定,可明显改善患者生活质量,毒性可耐受。     

术前盆腔对比增强MRI评估子宫内膜癌子宫肌层浸润程度

目的 探讨术前盆腔对比增强MRI对子宫内膜癌子宫肌层浸润程度的诊断价值。方法 回顾性分析89例经手术病理确诊的子宫内膜癌患者,术前均以盆腔对比增强MRI评估肌层浸润程度,并与术后病理结果进行比较,评价术前对比增强MRI对子宫内膜癌肌层浸润程度的诊断效能。结果 术前盆腔MRI示病变区子宫内膜均呈不均匀中-高信号强度,子宫肌层内边缘不清,结合带中断,受累肌壁呈不均匀高信号。术前对比增强MRI诊断62例浅肌层浸润,27例深肌层浸润;术后病理诊断浅肌层浸润63例,深肌层浸润26例。术前对比增强MRI诊断浅肌层浸润的敏感度90.48%（57/63）,特异度80.77%（21/26）,阳性预测值91.94%（57/62）,阴性预测值77.78%（21/27）,准确率87.64%（78/89）;诊断深肌层浸润敏感度80.77%（21/26）,特异度90.48%（57/63）,阳性预测值77.78%（21/27）,阴性预测值91.94%（57/62）,准确率87.64%（78/89）。结论 术前盆腔对比增强MRI评估子宫内膜癌子宫肌层浸润程度的效能较高。     

Long-Term Performance Evolution of RIOHTrack Pavement Surface Layer Based on DMA Method

Asphalt mixture is a typical viscoelastic material, and its road performance will change with the action of environment and load during actual service. This study conducted experimental research on the surface course asphalt mixture of three categories and six typical structures of RIOHTrack based on the Dynamic Mechanical Analysis method. Moreover, this study explored the performance evolution law of asphalt mixture under the coupling action of load and environment in the process of loading from 0 million to 54 million standard axle times. Results demonstrated that the phase transition characteristic temperature of the surface course materials of the three types of typical structures showed a trend of first increasing and then decreasing with the accumulation of load and environmental effects, indicating the presence of two stages of the dual coupling effect of environmental aging and load rolling on the asphalt mixture during service. In addition, the results suggested that the phase transition characteristic temperature, modulus, and phase angle of the surface layer materials have obvious material differences and structure dependencies.     

长春胺缓释胶囊治疗非动脉炎性前部缺血性视神经病变的效果与安全性

目的 研究长春胺缓释胶囊治疗非动脉炎性前部缺血性视神经病变（NAION）的效果及安全性。方法 选取沈阳市兴齐眼科医院及沈阳市第四人民医院2017年1月至2021年1月收治的44例44眼非动脉炎性前部缺血性视神经病变患者进行研究,按治疗时间分为对照组与研究组,两组患者均22例22眼。对照组（2017年1月至2019年12月）患者采取常规药物治疗,研究组（2020年1月至2021年1月）患者在对照组的基础上加用长春胺缓释胶囊治疗。观察两组患者治疗前后的视力、视野平均缺损、电生理指标、形态学指标。结果 两组患者治疗前的最佳矫正视力（BCVA）、视野平均缺损、图形视觉诱发电位（PVEP）振幅及潜时值、盘周神经纤维层厚度（RNFL）、视网膜神经节细胞复合体厚度（GCC）比较,差异无统计学意义（P>0.05）;对照组治疗前后的PVEP振幅及潜时值比较,差异无统计学意义（P>0.05）;两组患者治疗后的视力、视野平均缺损、RNFL、GCC均低于治疗前,研究组治疗后的视力、视野平均缺损、PVEP振幅及潜时值均低于对照组,且研究组治疗后的PVEP振幅及潜时值均低于治疗前,差异均有统计学意义（...     

电针联合手法整复对胸椎小关节紊乱患者临床观察

目的：比较电针联合手法整复治疗与单纯手法治疗胸椎小关节紊乱患者的临床疗效及疼痛改善情况,为电针联合手法整复治疗胸椎小关节紊乱提供临床依据。方法将2013年4月至2014年6月于我院针灸科门诊进行治疗的84例胸椎小关节紊乱患者随机分为对照组和观察组各42例,对照组采用单纯手法治疗,观察组使用电针联合手法整复治疗。比较两者患者在临床疗效及治疗前后疼痛改善情况的差异。结果观察组治愈率和总有效率分别为54.76%和95.24%,显著高于对照组的19.05%及76.19%(P<0.05);观察组患者PRI、 VAS、 PPI治疗前后差值与对照组PRI、 VAS、 PPI治疗前后差值相比均有显著性差异(P<0.05)。结论电针联合手法整复治疗胸椎小关节紊乱的临床疗效优于单纯手法治疗,且更能降低患者疼痛程度,值得在临床上推广应用。     

医疗设备融资租赁前景展望

医疗设备融资租赁正作为一种重要的手段被越来越多的医院和社会资本所采用,本文介绍了我国医疗设备租赁行业的发展现状,对租赁平台、租赁方式和租赁产品等今后的发展趋势做了进一步的分析和展望。     

二代测序技术检测鼻咽癌相关基因突变与临床病理特征关系分析

目的:以二代测序(N GS)为基础分析鼻咽癌相关基因突变及突变功能区域,探讨突变基因与临床特征之间的关系及临床应用价值.方法:收集2018年2月-2018年11月中南大学湘雅医学院附属肿瘤医院/湖南省肿瘤医院头颈放疗二科28例初治鼻咽癌患者,采用基因测序平台Illumina NextSeqCN500进行全基因测序,描述...     

神经系统动力学数学模型的研究进展

随着人们对大脑研究的进一步深入,诞生了神经系统动力学这一门新兴学科,大脑的数学模型是该学科研究的基础。本文介绍了一系列具有代表性和广阔应用范围的神经元数学模型,并就此展开讨论,对其发展前景作了展望;最后,将其与复杂网络研究相结合,提出了有价值的研究方向。     

Protective Role of Taurine Against Morphine-Induced Neurotoxicity in C6 Cells via Inhibition of Oxidative Stress

This study was carried out to investigate the protective role of taurine (2-aminoethanesulphonicacid) against morphine-induced neurotoxicity in C6 cells. It was found that taurine significantly increased the viability of C6 cells treated by morphine, showing the neuroprotective role against morphine-induced neurotoxicity. However, such neuroprotective effect of taurine could not be blocked by bicuculline, an antagonist of gamma-amino butyrate (GABA) receptor. To determine the oxidative damage induced by morphine, the superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were measured in C6 cells. The decreased activities of SOD, CAT, and GPx in C6 cells were observed after morphine treatment for 48 h. However, taurine administration effectively ameliorated morphine-induced oxidative insult. To estimate anti-apoptosis effect of taurine, flow cytometry analysis as well as detection for caspase-3 and Bcl-2 expressions was performed after morphine exposure for 48 h. It was found that Bcl-2 expression was down regulated by morphine, whereas taurine could reverse morphine-induced decrease in Bcl-2 expression. Taurine showed no effect on caspase-3 expression. Collectively, the results show that taurine possesses the capability to ameliorate morphine-induced oxidative insult and apoptosis in C6 cells, probably due to its antioxidant activity rather than activation of GABA receptors.     

原发系统性间变性大细胞淋巴瘤18F-FDG PET/CT表现

目的 观察原发系统性间变性大细胞淋巴瘤(ALCL)¹⁸F-FDG PET/CT表现。方法 纳入21例原发系统性ALCL,观察病灶PET/CT表现。结果 21例中,15例ALK⁺、6例ALK^-ALCL;19例累及多部位淋巴结,主要包括颈部(13例)、纵隔(12例)及腹膜后(12例)淋巴结,2例仅累及单一部位淋巴结。12例累及结外器官/部位,其中6例累及软组织如皮肤、肌肉等,4例累及骨骼,14例累及脏器,包括肺部(4例)、肝脏(3例)、胰腺(2例)、肾脏(2例)、胃肠道(2例)及甲状腺(1例)。21例中,19例淋巴结形态欠规则并融合成团,17例密度均匀,3例可见坏死,1例可见钙化。21例病灶均表现为高代谢,受累淋巴结最大标准摄取值(SUV_max)、平均标准摄取值(SUV_mean)分别为17.04±9.94、9.96±6.15,全部病灶肿瘤代谢体积(MTV)、病灶糖酵解总量(TLG)分别为92.54(67.61,249.21)cm³、723.46(419.78,...