全文获取类型
收费全文 | 4025篇 |
免费 | 273篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 33篇 |
儿科学 | 102篇 |
妇产科学 | 29篇 |
基础医学 | 776篇 |
口腔科学 | 51篇 |
临床医学 | 349篇 |
内科学 | 815篇 |
皮肤病学 | 99篇 |
神经病学 | 491篇 |
特种医学 | 147篇 |
外国民族医学 | 8篇 |
外科学 | 659篇 |
综合类 | 18篇 |
一般理论 | 1篇 |
预防医学 | 185篇 |
眼科学 | 36篇 |
药学 | 213篇 |
中国医学 | 5篇 |
肿瘤学 | 291篇 |
出版年
2023年 | 26篇 |
2022年 | 39篇 |
2021年 | 104篇 |
2020年 | 66篇 |
2019年 | 72篇 |
2018年 | 114篇 |
2017年 | 71篇 |
2016年 | 66篇 |
2015年 | 86篇 |
2014年 | 124篇 |
2013年 | 165篇 |
2012年 | 263篇 |
2011年 | 273篇 |
2010年 | 134篇 |
2009年 | 137篇 |
2008年 | 179篇 |
2007年 | 197篇 |
2006年 | 184篇 |
2005年 | 167篇 |
2004年 | 165篇 |
2003年 | 150篇 |
2002年 | 144篇 |
2001年 | 108篇 |
2000年 | 116篇 |
1999年 | 102篇 |
1998年 | 42篇 |
1997年 | 51篇 |
1996年 | 28篇 |
1995年 | 26篇 |
1994年 | 45篇 |
1993年 | 37篇 |
1992年 | 79篇 |
1991年 | 60篇 |
1990年 | 54篇 |
1989年 | 54篇 |
1988年 | 44篇 |
1987年 | 58篇 |
1986年 | 60篇 |
1985年 | 52篇 |
1984年 | 46篇 |
1983年 | 26篇 |
1979年 | 29篇 |
1978年 | 17篇 |
1977年 | 24篇 |
1974年 | 15篇 |
1973年 | 20篇 |
1972年 | 16篇 |
1971年 | 16篇 |
1970年 | 32篇 |
1968年 | 20篇 |
排序方式: 共有4308条查询结果,搜索用时 15 毫秒
111.
112.
Virginie Pécourneau Yannick Degboé Thomas Barnetche Alain Cantagrel Arnaud Constantin Adeline Ruyssen-Witrand 《Archives of physical medicine and rehabilitation》2018,99(2):383-389.e1
Objective
To assess the effectiveness of exercise programs on disease activity and function in ankylosing spondylitis (AS) by a systematic review and meta-analysis of randomized controlled trials (RCTs).Data Sources
Medline via PubMed and Cochrane Library.Study Selection
Reports of RCTs examining the effectiveness of exercise programs for AS published up to May 2017.Data Extraction
Outcomes were evolution of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI) after the completion of exercise programs. Modalities of exercise were compared and the use of biologic therapy was reported.Data Synthesis
After screening 190 abstracts, we selected 26 reports for detailed evaluation and finally investigated 8 trials that assessed a home-based exercise program (2/8), swimming (1/8), Pilates training (1/8), or supervised exercises (4/8), for a total of 331 patients with AS. Four trials included patients receiving antitumor necrosis factor therapy. All trials except one showed a decrease in BASDAI and BASFI with exercise. The weighted mean difference was ?0.90 (95% confidence interval, ?1.52 to ?0.27; I2=69%; P=.005) for the BASDAI and ?0.72 (95% confidence interval, ?1.03 to ?0.40; I2=0%; P<.00001) for the BASFI in favor of exercise programs.Conclusions
Despite the small number of patients and the heterogeneity of exercise programs in the RCTs included in this meta-analysis, its results support the potential of exercise programs to improve disease activity and body function in AS. 相似文献113.
Gayle Langley William Schaffner Monica M. Farley Ruth Lynfield Nancy M. Bennett Arthur Reingold Ann Thomas Lee H. Harrison Megin Nichols Susan Petit Lisa Miller Matthew R. Moore Stephanie J. Schrag Fernanda C. Lessa Tami H. Skoff Jessica R. MacNeil Elizabeth C. Briere Emily J. Weston Chris Van Beneden 《Emerging infectious diseases》2015,21(9):1520-1528
Active Bacterial Core surveillance (ABCs) was established in 1995 as part of the Centers for Disease Control and Prevention Emerging Infections Program (EIP) network to assess the extent of invasive bacterial infections of public health importance. ABCs is distinctive among surveillance systems because of its large, population-based, geographically diverse catchment area; active laboratory-based identification of cases to ensure complete case capture; detailed collection of epidemiologic information paired with laboratory isolates; infrastructure that allows for more in-depth investigations; and sustained commitment of public health, academic, and clinical partners to maintain the system. ABCs has directly affected public health policies and practices through the development and evaluation of vaccines and other prevention strategies, the monitoring of antimicrobial drug resistance, and the response to public health emergencies and other emerging infections. 相似文献
114.
115.
116.
117.
Monatsschrift Kinderheilkunde - Bereits in den frühen 1990er-Jahren wurde erstmals eine durch einen mRNA-Impfstoff ausgelöste Immunantwort beschrieben. Seitdem wurden mRNA-Impfstoffe... 相似文献
118.
119.
Since 1976, patients grafted at the Hopital Saint-Louis for Fanconi anemia (FA) without evidence of leukemic transformation have been given a uniform conditioning regimen that consisted of low-dose cyclophosphamide (Cy) and thoracoabdominal irradiation (TAI). The use of low-dose Cy raised the question of whether it is sufficient for the establishment of a complete hematopoietic chimerism in all patients. We therefore initiated a study of chimerism early during hematopoietic reconstitution after bone marrow transplantation (BMT) and thereafter in transplanted FA patients. Minisatellite probes were used after DNA amplification by the polymerase chain reaction (PCR). From July 1989 to October 1992, 24 consecutive patients underwent BMT for FA, 19 of whom were assessable for chimerism. Our results using this sensitive technique showed that, among these 19 patients, all but one successfully engrafted. Engraftment was complete early after BMT in 12. The persistence of a small proportion of recipient's cells was detected in six. This partial hematopoietic chimerism was demonstrated to be only transient in at least five of the six patients. The one patient who failed to engraft showed a recipient-type profile for circulating cells early posttransplantation, indicating autologous bone marrow recovery. A second graft in this patient was also rejected. For both transplantations, the patient was grafted from a matched, unrelated donor. Therefore, 17 of 17 patients successfully grafted and with complete follow up data presented complete hematopoietic chimerism, within the sensitivity limit of the method used. In conclusion, lowering the Cy dose in the conditioning regimen of patients with FA could still allow complete engraftment to occur, at least in patients with an identical sibling donor. 相似文献
120.