安徽省2007～2008年志贺氏菌流行株菌型分布及脉冲场分子分型

目的了解安徽省志贺氏菌的流行菌型,并建立脉冲场凝胶电泳（PFGE）分子分型方法,为菌痢防控提供理论基础。方法对22株志贺氏菌进行血清分型、药物敏感试验和PFGE试验。结果22株志贺氏菌血清分型：B群19株,占总数86.5%;C群1株,占总数的4.5%;D群2株,占总数的9.0%。成功建立了菌痢的PFGE分子分型方法,并将我省22株流行株分为若干带型。试验结果进一步作聚类分析。结论安徽省菌痢流行株以福氏为主;安徽省PFGE分子分型方法和初步带型数据库对提高细菌检测水平有一定意义。     

多种医疗功能的集成设计——以山东烟台芝罘区南部新城医院为例

文章以山东烟台芝罘区南部新城医院为例,从出入口设置、整体布局、功能分区、景观绿化、外形设计等方面介绍了集多种医疗功能于一体的医院建筑的设计方法和思路。     

Corrosion Behavior of Alx(CrFeNi)1−x HEA under Simulated PWR Primary Water

High-entropy alloys (HEAs) have great potential as accident-tolerant fuel (ATF) cladding. Aluminum-forming duplex (BCC and FCC) stainless-steel (ADSS) is a candidate for ATF cladding, but the multiphase composition is detrimental to its corrosion resistance. In this paper, two single-phase HEAs were prepared by adjusting the content of each element in the ADSS alloy. The two HEAs were designed as Al_0.05(CrFeNi)_0.95(FCC) and Al_0.25(FeCrNi)_0.75(BCC). Their corrosion behavior under simulated pressurized water reactor (PWR) primary water was investigated. The corrosion products and corrosion mechanisms of these two HEAs were explored. The results show that the corrosion resistance of HEA alloys containing FCC is better than that of BCC and ADSS alloys. At the same time, the reason why the BCC structure composed of these four elements is not resistant to corrosion is revealed.     

语音播报提醒功能对早期药物临床试验中采血时间的影响

目的 探讨语音播报提醒功能对早期药物临床试验中采血时间准确性的影响。方法 自Sample Guide智能样本管理系统数据库中调取2018年6月—2019年10月无语音播报提醒功能条件下6 558个血液样本采集时间作为对照组;2019年12月—2021年2月启用语音播报提醒功能后12 768个血液样本采集时间作为试验组。比较两组实际采血时间与计划采血时间的偏离程度、采血时间超窗发生率、采血时间记录异常发生率。结果 启用语音播报提醒功能后,实际采血时间与计划采血时间的偏离程度较小,差值绝对值比较差异有统计学意义（P<0.05）;采血时间超窗发生率明显降低,差异有统计学意义（P<0.05）;采血时间记录异常的发生率明显降低,差异有统计学意义（P<0.05）。结论 语音播报提醒功能可以缩短实际采血时间与计划时间的偏离程度,有效减少药物临床试验中采血时间超窗次数的发生,提高了早期药物临床试验中采血时间的准确度。     

Quantitative chemical sensing of drugs in scattering media with Bessel beam Raman spectroscopy

Scattering can seriously affect the highly sensitive detection and quantitative analysis of chemical substances in scattering media and becomes a significant challenge for in vivo application of Raman spectroscopy. In this study, we demonstrated a proof of concept for using the self-reconstructing Bessel beam for Raman spectroscopic sensing of the chemicals in the handmade scattering media and biological tissue slices. The homebuilt Bessel beam Raman spectroscopy (BRS) was capable of accurately detecting the Raman spectra of the chemicals buried in the scattering media, and had a superiority in quantitative analysis. The feasibility of the developed technique was verified by detecting the Raman spectra of pure samples in air. Compared with the spectra acquired by the Gaussian beam Raman spectroscope, the performance of the BRS system in terms of Raman spectrum detection and Raman peak recognition was confirmed. Subsequently, by employing the technique for the detection of acetaminophen buried in the scattering media, the application of the new technology in detecting and quantitating the chemicals in the scattering media were underlined, offering greater detection depth and better linear quantification capability than the conventional Gaussian beam Raman spectroscopy. Finally, we explored the potential of the BRS system for chemical sensing of acetaminophen in biological tissue slices, indicating a significant development towards the evaluation of drug in vivo.     

火焰原子吸收法测定复方十一烯酸锌软膏中锌的含量

目的建立火焰原子吸收法测定复方十一烯酸锌软膏中锌的含量。方法检测波长为213.9nm,灯电流为8.0mA,狭缝宽度为0.5nm,燃气流量为2.0L/min,助燃气流量为15.0L/min。结果Zn在0.0000~2.0000mg·L-1范围内线性关系良好,r=0.9984,平均加样回收率为99.53%,RSD为0.2%,n=9。结论该质量标准的研究有效控制了复方十一烯酸锌软膏的质量,方法简单、结果准确、灵敏度高。     

对照军队医院等级评审谈武警部队医院营养科建设

营养科的建设与发展水平直接关系到患者的康复,也关系到医院的整体医疗质量水平。笔者通过解读《军队三级综合医院等级评审标准和细则》,对医院营养工作的难点进行分析,总结了武警部队营养科建设目前存在的问题,并提出营养科下一步发展对策。     

Endoscopic features of esophageal high-grade intraepithelial neoplasia dominated by cytological atypia

Little is known about esophageal high-grade intraepithelial neoplasia dominated by cytological atypia (HGINc). We aimed to elucidate the endoscopic features of HGINc compared with esophageal high-grade intraepithelial neoplasia dominated by architectural atypia (HGINa). All patients pathologically diagnosed as esophageal high-grade intraepithelial neoplasia after endoscopic submucosal dissection at our center between January 2018 and December 2019 were included in this study. According to the pathological diagnosis, the patients were divided into two groups: HGINa group and HGINc group. Basic characteristics and endoscopic information were collected in detail. Data were analyzed statistically. Binary logistic regression was performed and a predictive model for HGINc was established. Then we evaluated its predictive value and built a nomogram for clinical application. A total of 175 patients were included in this study (126 with HGINa and 49 with HGINc). Among 228 lesions found in all patients, there were 148 HGINa and 80 HGINc. The independent relevant factors for HGINc were tobacco and alcohol usage, color, and gross type. To predict risk of HGINc, a three-factor model (TFM) was established with a highest area under curve (AUC) as 0.869 (95% CI, 0.852, 0.939). When the cut-off value was set as 0.3569184, the diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value for HGINc was 81.14%, 88.75%, 77.03%, 67.62%, and 92.68%, respectively. HGINc differs greatly in endoscopic features from HGINa in our study. It’s important to reduce misdiagnosis that our model was established with good predictive value for clinical application.     

知人能力测验在重性精神疾病筛检中的有效性分析

【目的】探讨知人能力测验应用于重性精神疾病筛检的有效性问题。【方法】采用知人能力测验,对武警某部698名新兵进行团体施测,以测验、回访、诊断的结果作为效度指标,计算知人能力测验的正确诊断指数。【结果】知人能力测验的灵敏度为100％,特异度为92％,正确诊断指数为0．92。【结论】知人能力测验的效度指标符合测验学要求,可以作为重性精神疾病筛检的研究和使用工具。