全文获取类型
收费全文 | 480858篇 |
免费 | 63706篇 |
国内免费 | 25535篇 |
专业分类
耳鼻咽喉 | 7871篇 |
儿科学 | 9170篇 |
妇产科学 | 6582篇 |
基础医学 | 39812篇 |
口腔科学 | 7451篇 |
临床医学 | 73201篇 |
内科学 | 91631篇 |
皮肤病学 | 10921篇 |
神经病学 | 30422篇 |
特种医学 | 18389篇 |
外国民族医学 | 171篇 |
外科学 | 70241篇 |
综合类 | 62724篇 |
现状与发展 | 155篇 |
一般理论 | 26篇 |
预防医学 | 31090篇 |
眼科学 | 13100篇 |
药学 | 37271篇 |
396篇 | |
中国医学 | 22295篇 |
肿瘤学 | 37180篇 |
出版年
2024年 | 1457篇 |
2023年 | 9162篇 |
2022年 | 12990篇 |
2021年 | 19844篇 |
2020年 | 18731篇 |
2019年 | 12758篇 |
2018年 | 18405篇 |
2017年 | 18025篇 |
2016年 | 17870篇 |
2015年 | 23695篇 |
2014年 | 34252篇 |
2013年 | 32996篇 |
2012年 | 31804篇 |
2011年 | 34384篇 |
2010年 | 29534篇 |
2009年 | 29574篇 |
2008年 | 24834篇 |
2007年 | 22766篇 |
2006年 | 24462篇 |
2005年 | 20944篇 |
2004年 | 13974篇 |
2003年 | 12265篇 |
2002年 | 10574篇 |
2001年 | 11142篇 |
2000年 | 10324篇 |
1999年 | 10345篇 |
1998年 | 7984篇 |
1997年 | 7767篇 |
1996年 | 6781篇 |
1995年 | 6342篇 |
1994年 | 4588篇 |
1993年 | 3228篇 |
1992年 | 3544篇 |
1991年 | 3261篇 |
1990年 | 2575篇 |
1989年 | 2445篇 |
1988年 | 2197篇 |
1987年 | 1855篇 |
1986年 | 1696篇 |
1985年 | 1317篇 |
1984年 | 918篇 |
1983年 | 794篇 |
1982年 | 673篇 |
1981年 | 553篇 |
1980年 | 474篇 |
1979年 | 459篇 |
1978年 | 378篇 |
1977年 | 450篇 |
1975年 | 338篇 |
1972年 | 348篇 |
排序方式: 共有10000条查询结果,搜索用时 218 毫秒
131.
目的探讨用3M无痛保护膜联合造口袋治疗大便失禁相关性皮炎(Incontinent dermatitis,IAD)的疗效。方法选择我院2014年12月至2015年6月收治的50例IAD患者为研究对象,按照随机数表法将其分为对照组与实验组,每组25例。对照组患者予以传统皮肤护理方法;实验组的患者除传统皮肤护理外加用3M无痛保护膜联合造口袋治疗。并比较两组患者治疗后的皮炎改善情况、皮炎愈合时间及皮炎复发率。结果实验组患者治疗效果明显优于对照组,实验组皮炎愈合短于对照组,实验组皮炎复发率明显低于对照组,差异均有统计学意义(P<0.05)。结论 3M无痛保护膜联合造口袋治疗IAD,临床效果显著,且愈合快,复发低。 相似文献
132.
Henry Havel Gregory Finch Pamela Strode Marc Wolfgang Stephen Zale Iulian Bobe Hagop Youssoufian Matthew Peterson Maggie Liu 《The AAPS journal》2016,18(6):1373-1378
Advancing nanomedicines from concept to clinic requires integration of new science with traditional pharmaceutical development. The medical and commercial success of nanomedicines is greatly facilitated when those charged with developing nanomedicines are cognizant of the unique opportunities and technical challenges that these products present. These individuals must also be knowledgeable about the processes of clinical and product development, including regulatory considerations, to maximize the odds for successful product registration. This article outlines these topics with a goal to accelerate the combination of academic innovation with collaborative industrial scientists who understand pharmaceutical development and regulatory approval requirements—only together can they realize the full potential of nanomedicines for patients. 相似文献
133.
134.
Background:Gastrointestinal complications and malnutrition are common problems that affect postoperative rehabilitation and survival of patients with esophageal cancer. Evidence has shown that probiotics have a positive effect on improving gastrointestinal complications and nutritional status of patients with esophageal cancer after surgery, but there is a lack of prospective studies on this topic. We designed this prospective randomized controlled trial to evaluate the effects of probiotics on gastrointestinal complications and nutritional status in patients with postoperative esophageal cancer.Methods:This is a prospective, randomized, double-blind, placebo-controlled trial. It was approved by the Clinical Research Ethics Committee of our hospital. 192 patients will be randomly divided into probiotics group and the placebo group in a 1:1 ratio. After operation, probiotics and placebo will be given orally for 8 weeks. The indexes of nutritional status and incidence of digestive tract complications will be recorded and the data will be analyzed by SPSS 18.0 software.Discussion:This study will evaluate the effect of probiotics on gastrointestinal complications and nutritional status of postoperative patients with esophageal cancer. The results of this study will provide clinical basis for the use of probiotics in postoperative treatment of esophageal cancer.Trial registration:OSF Registration number: D DOI 10.17605/OSF.IO/QHW86 相似文献
135.
The term “oligometastatic prostate cancer” refers to a heterogeneous group of disease states currently defined solely on the basis of clinical features. Oligorecurrent disease, de novo oligometastases, and oligoprogressive disease likely have unique biologic underpinnings and natural histories. Evidence suggesting the existence of a subset of patients who harbor prostate cancer with limited metastatic potential currently includes disparate and overwhelmingly retrospective reports. Nevertheless, emerging prospective data have corroborated the “better-than-expected,” retrospectively observed outcomes, particularly in the setting of oligorecurrent prostate cancer. Improved functional imaging with prostate-specific membrane antigen-targeted strategies may enhance the identification of patients with oligometastatic prostate cancer in the short term. In the long term, refinement of the oligometastatic case definition likely will require biologic risk-stratification schemes. To determine optimal treatment strategies and identify patients most likely to benefit from metastasis-directed therapy, future efforts should focus on conducting high-quality, prospective trials with much-needed molecular correlative studies. 相似文献
136.
miR-30c has been acknowledged as a tumor suppressor in various human cancers, such as ovarian cancer, gastric cancer, and prostate cancer. However, the role of miR-30c in glioblastoma (GBM) needs to be investigated.
In our study, we found that the expression of miR-30c was significantly downregulated in GBM tissues and
cell lines. We found that overexpression of miR-30c inhibited cellular proliferation of GBM cells in vitro and
in vivo. More GBM cells were arrested in the G0 phase after miR-30c overexpression. Moreover, we showed
that miR-30c overexpression suppressed the migration and invasion of GBM cells. Mechanistically, we found
that SOX9 was a direct target of miR-30c in GBM cells. Overexpression of miR-30c inhibited the mRNA
and protein levels of SOX9 in GBM cells. Moreover, there was a negative correlation between the expression
of miR-30c and SOX9 in GBM tissues. Finally, we showed that restoration of SOX9 in GBM cells reversed
the proliferation, migration, and invasion of GBM cells transfected with miR-30c mimic. Collectively, our
results demonstrated that miR-30c suppressed the proliferation, migration, and invasion of GBM cells via
targeting SOX9. 相似文献
137.
138.
139.
140.