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Sarah Yale MD Nicole Stefanko MD Patrick McCarthy MD MME Vanessa McFadden MD PhD James McCarthy MD 《Pediatric dermatology》2020,37(2):377-378
Dapsone gel is a topical treatment for facial acne in adolescents and adults, and while systemic dapsone therapy is known to be associated with methemoglobinemia, once-daily topical dapsone has been well tolerated with few side effects in large randomized controlled trials. We describe the first reported case of severe methemoglobinemia in a healthy adolescent using daily topical dapsone. Although the medication was prescribed for facial use only, the patient reported topical use over her back and chest as well. This case illustrates the potential for significant systemic dapsone absorption even with daily topical dosing and demonstrates the need for clear anticipatory guidance to prevent the potential morbidity and mortality associated with methemoglobinemia from improper topical dapsone use. 相似文献
13.
Robert J. Williams Carrie A. Leonard Yale D. Belanger Darren R. Christensen Nady el-Guebaly David C. Hodgins Daniel S. McGrath Fiona Nicoll Rhys M.G. Stevens 《Revue canadienne de psychiatrie》2021,66(5):485
Objective:The purpose of this study was to provide an updated profile of gambling and problem gambling in Canada and to examine how the rates and pattern of participation compare to 2002.Method:An assessment of gambling and problem gambling was included in the 2018 Canadian Community Health Survey and administered to 24,982 individuals aged 15 and older. The present analyses selected for adults (18+).Results:A total of 66.2% of people reported engaging in some type of gambling in 2018, primarily lottery and/or raffle tickets, the only type in which the majority of Canadians participate. There are some significant interprovincial differences, with perhaps the most important one being the higher rate of electronic gambling machine (EGM) participation in Manitoba and Saskatchewan. The overall pattern of gambling in 2018 is very similar to 2002, although participation is generally much lower in 2018, particularly for EGMs and bingo. Only 0.6% of the population were identified as problem gamblers in 2018, with an additional 2.7% being at-risk gamblers. There is no significant interprovincial variation in problem gambling rates. The interprovincial pattern of problem gambling in 2018 is also very similar to what was found in 2002 with the main difference being a 45% decrease in the overall prevalence of problem gambling.Conclusions:Gambling and problem gambling have both decreased in Canada from 2002 to 2018 although the provincial patterns are quite similar between the 2 time periods. Several mechanisms have likely collectively contributed to these declines. Decreases have also been reported in several other Western countries in recent years and have occurred despite the expansion of legal gambling opportunities, suggesting a degree of inoculation or adaptation in large parts of the population. 相似文献
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Sax PE DeJesus E Mills A Zolopa A Cohen C Wohl D Gallant JE Liu HC Zhong L Yale K White K Kearney BP Szwarcberg J Quirk E Cheng AK;GS-US-- study team 《Lancet》2012,379(9835):2439-2448
17.
RJ Ligthelm M Kaiser J Vora JF Yale 《Journal of the American Geriatrics Society》2012,60(8):1564-1570
Hypoglycemia is a significant problem in elderly adults with diabetes mellitus. Elderly individuals with diabetes mellitus are at greater risk than younger adults for hypoglycemic events. Several factors contribute to this risk, including the high prevalence of comorbidities, polypharmacy, cognitive impairment, and concomitant use of agents that interfere with glucose metabolism. To minimize the risk of hypoglycemia and maximize the benefits of glycemic control, guidelines typically recommend individualizing glycosylated hemoglobin (HbA1c) targets based on life expectancy, functional status, and individual goals. Although many individuals with type 2 diabetes mellitus will ultimately require insulin therapy to achieve and maintain glycemic control, earlier insulin initiation in elderly individuals may be warranted, particularly in those with renal, cardiovascular, or hepatic concerns that could interfere with the use of oral agents. There are few data on the use of insulin-or other glucose-lowering agents-in elderly adults, but limited evidence suggests that the use of insulin, especially insulin analogs, may be appropriate in this population. Insulin analogs offer a better pharmacokinetic profile, greater convenience, and less variable glycemic control than human insulin. Because of the high prevalence of cognitive impairment and other geriatric syndromes in elderly adults, clinicians should perform a comprehensive assessment of patients' ability to administer and monitor insulin therapy and recognize and treat hypoglycemia. 相似文献
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Annette Feigenbaum Christine Müller Christopher Yale Johannes Kleinheinz Peter Jezewski Hans Gerd Kehl Mary MacDougall Frank Rutsch Raoul C.M. Hennekam 《American journal of medical genetics. Part A》2013,161(2):360-370
In 1973, Singleton and Merten described two females with abnormal dentition, unique radiographic changes especially of the hands, and severe calcification and intimal weakening of the aortic arch and valve. Since then three additional cases with similar features have been reported and the diagnosis was suggested in another three individuals. We present an update of one case and the detailed clinical phenotype of six other cases with Singleton–Merten syndrome. The occurrence of the disorder in six members of two families and vertical male‐to‐male transmission indicate an autosomal dominant pattern of inheritance. Variability in phenotype, also within a single family, is significant. Core manifestations are marked aortic calcification, dental anomalies (delayed eruption and immature root formation of primarily the anterior permanent teeth, and early loss of permanent teeth due to short roots, acute root resorption, high caries, and aggressive alveolar bone loss), osteopenia and acro‐osteolysis, and to a lesser extend also glaucoma, psoriasis, muscle weakness, and joint laxity. Additional clinical characteristics described here include particular facial characteristics (high anterior hairline, broad forehead, smooth philtrum, thin upper vermillion) and abnormal joint and muscle ligaments. The cause and pathogenesis of this syndrome remain unknown. © 2013 Wiley Periodicals, Inc. 相似文献
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Michael Megaly MD MS Matthew Glogoza MD Iosif Xenogiannis MD Evangelia Vemmou MD Ilias Nikolakopoulos MD Laura Willson MD David J. Monyak MD Patsa Sullivan MD Larissa Stanberry PhD Paul Sorajja MD Ivan Chavez MD Michael Mooney MD Jay Traverse MD Yale Wang MD Santiago Garcia MD Anil Poulose MD Martin Nicholas Burke MD Emmanouil S. Brilakis MD PhD 《Catheterization and cardiovascular interventions》2021,97(1):32-38
20.
Ann Iverson Larissa I. Stanberry Peter Tajti Ross Garberich Amber Antos M. Nicholas Burke Ivan Chavez Mario Gössl Timothy D. Henry Daniel Lips Michael Mooney Anil Poulose Paul Sorajja Jay Traverse Yale Wang Steven Bradley Emmanouil S. Brilakis 《Cardiovascular Revascularization Medicine》2019,20(4):289-292