全文获取类型
收费全文 | 478篇 |
免费 | 11篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 37篇 |
妇产科学 | 2篇 |
基础医学 | 43篇 |
口腔科学 | 2篇 |
临床医学 | 41篇 |
内科学 | 100篇 |
皮肤病学 | 25篇 |
神经病学 | 34篇 |
外科学 | 68篇 |
综合类 | 8篇 |
预防医学 | 11篇 |
眼科学 | 14篇 |
药学 | 53篇 |
肿瘤学 | 42篇 |
出版年
2022年 | 3篇 |
2021年 | 6篇 |
2015年 | 6篇 |
2014年 | 7篇 |
2013年 | 4篇 |
2012年 | 7篇 |
2011年 | 5篇 |
2010年 | 8篇 |
2009年 | 15篇 |
2008年 | 4篇 |
2007年 | 9篇 |
2006年 | 18篇 |
2005年 | 12篇 |
2004年 | 7篇 |
2003年 | 8篇 |
2002年 | 3篇 |
2001年 | 4篇 |
1999年 | 12篇 |
1998年 | 23篇 |
1997年 | 19篇 |
1996年 | 26篇 |
1995年 | 29篇 |
1994年 | 19篇 |
1993年 | 16篇 |
1992年 | 12篇 |
1991年 | 10篇 |
1990年 | 8篇 |
1989年 | 9篇 |
1988年 | 11篇 |
1986年 | 9篇 |
1985年 | 9篇 |
1984年 | 10篇 |
1983年 | 4篇 |
1982年 | 4篇 |
1981年 | 5篇 |
1980年 | 7篇 |
1979年 | 5篇 |
1978年 | 6篇 |
1977年 | 5篇 |
1975年 | 4篇 |
1973年 | 2篇 |
1972年 | 3篇 |
1968年 | 2篇 |
1959年 | 5篇 |
1958年 | 8篇 |
1957年 | 23篇 |
1956年 | 16篇 |
1955年 | 17篇 |
1954年 | 11篇 |
1948年 | 3篇 |
排序方式: 共有490条查询结果,搜索用时 125 毫秒
61.
M. KIMURA A. KAWADA T. KOBAYASHl M. HIRUMA A. ISHIBASHI 《Clinical and experimental dermatology》1996,21(1):46-47
A case of photosensitivity induced by fleroxadn (FLRX) is reported. A 71-year-old man had erythema on sun-exposed areas after 5 months FLRX treatment for prostatitis. The minimal erythema dose to UVA was reduced at the initial examination and became normal 4 weeks after he stopped taking FLRX. Oral photo-challenge with FLRX 100 mg was positive, but photopatch testing was negative. 相似文献
62.
MAMI MURAI-KUSHIYA SATOSHI OKADA TOSHIO KIMURA RYUICHI HASEGAWA 《The Journal of pharmacy and pharmacology》1993,45(9):836-838
Abstract— Turpentine oil treatment (0·2 mL kg?1, s.c.) was used to increase the plasma concentration of α1-acid glycoprotein (0·13 mg mL?1 in control rats) to 1·72 mg mL?1 after 2 days, and allow assessment of its effects on the pharmacokinetics and stereoselective binding of three β-blockers. Racemates (5 mg kg?1) were administered intravenously to control and turpentine oil-pretreated rats and the plasma concentrations were determined up to 90 min. Stereoselective analysis showed the apparent distribution volume and the area under plasma concentration-time curves (AUC) of R-(+)-propranolol to be, respectively, one-quarter and twice those of the S-(–)-enantiomer and differences in pharmacokinetic parameters between the two were magnified by turpentine oil pretreatment. Pharmacokinetic parameters of oxprenolol enantiomers were essentially similar for the controls but after turpentine oil pretreatment, a higher affinity of the R-(+)-enantiomer for plasma was observed. Acebutolol enantiomers behaved non-stereospecifically throughout. These results were consistent with predictions from the in-vitro stereospecific binding properties of these agents to purified rat α1-acid glycoprotein. 相似文献
63.
BEGUM NURUN NESSA md TOSHIHISA TANAKA md phd KOUZIN KAMINO md phd GOLAM SADIK p hd ASHIK BIN ANSAR md RYO KIMURA p hd HISASHI TANII md phd MASAYASU OKOCHI md phd TAKASHI MORIHARA md phd SHINJI TAGAMI md phd TAKASHI KUDO md phd MASATOSHI TAKEDA md phd 《Psychiatry and clinical neurosciences》2006,60(S1):S27-S33
64.
We present the extremely rare phenotype of an accessory scrotum with an associated lipoblastoma. There was a coexistence of midperineal and lateral types. To our knowledge, this phenotype has never been reported. The lipoblastoma, which arose in the perineum, divided the moving labioscrotal swelling into three parts during early fetal life. This resulted in the specific anomaly in this patient. 相似文献
65.
BACKGROUND: The role of calcitonin gene-related peptide (CGRP) in prostate cancer has not been fully understood. Moreover, the serum CGRP level in prostate cancer patients has never been reported. We measured the serum CGRP levels in untreated prostate cancer patients to elucidate its clinical significance. MATERIALS AND METHODS: We used 36 serum samples from prostate cancer patients. All patients had never received any treatment. Serum CGRP was measured by immunoradiometric assay, and we analysed the association between serum CGRP level and clinicopathological factors. RESULTS: Serum CGRP levels in the patients with higher clinical stages and histological grade were significantly higher than in those with lower stages and grade, respectively. But the levels did not correlate with the patient's age, liver or renal functions, serum prostate-specific antigen levels. CONCLUSION: Serum CGRP levels were significantly elevated in the patients with high grade or high stage untreated prostate cancer patients. Measurement of the serum CGRP may be a useful predictor of staging or grading of prostate cancer in the untreated prostate cancer patients. 相似文献
66.
R. KIMURA T. SAKATA† Y. KOKUBO‡ A. OKAMOTO† A. OKAYAMA‡ H. TOMOIKE‡ T. MIYATA 《Journal of thrombosis and haemostasis》2006,4(9):2010-2013
BACKGROUND: Protein S (PS) is an anticoagulant protein that functions as a cofactor for activated protein C (APC), and congenital PS deficiency is a well-known risk factor for the development of deep vein thrombosis (DVT). Recently, we and others identified the K196E missense mutation in the second epidermal growth factor-like domain of PS as a genetic risk factor for DVT in the Japanese population. The incidence of this mutation is high in the Japanese population. OBJECTIVES: In the present study, we investigated the relationship between plasma PS activity and the presence of the K196E mutation. Patients and methods: We measured PS activity as a cofactor activity for APC in 1,862 Japanese individuals and determined the PS K196E genotype in this population. RESULTS: Individuals heterozygous for the mutant E-allele had lower plasma PS activity than wildtype subjects (mean +/- SD, 71.9 +/- 17.6%, n = 34 vs. 87.9 +/- 19.8%, n = 1,828, P < 0.0001). However, the PS activity of several heterozygous individuals (n = 8) was greater than the population average. In contrast, multiple wildtype subjects (n = 26) had PS activity less than 2 SD below the population mean, indicating that other genetic or environmental factors affect PS activity. CONCLUSIONS: Plasma PS activity itself is not suitable for identifying PS 196E carriers and other methods are required for carrier detection. 相似文献
67.
TAIJI SAWAMOTO SHUNJI HARUTA YUJI KUROSAKI KAZUTAKA HIGAKI TOSHIKIRO KIMURA 《The Journal of pharmacy and pharmacology》1997,49(4):450-457
A new method based on gastrointestinal transit kinetics has been developed for estimation of the absorption profiles of drugs administered orally as aqueous solutions. The utility of the method was evaluated in rats. The gastrointestinal transit profile for each segment was estimated by in-vivo studies using phenol red, an unabsorbable marker. The gastrointestinal transit profile of phenol red was well explained by a linear gastrointestinal transit kinetic model with eight segments. We also introduced the absorption process into the gastrointestinal transit kinetic model and the plasma profile was predicted by the convolution method. The absorbability of drugs in each segment was assessed by an in-situ absorption study. The validity of the model was evaluated for model drugs with different absorption characteristics. The plasma profiles predicted for ampicillin, theophylline and cephalexin were in good agreement with those observed. The overestimated plasma profile of propranolol suggests that the low bioavailability of propranolol is a result of first-pass metabolism by the intestine wall and the liver, because the calculated absolute absorption is almost perfect. This proposed model is also suitable for estimation of segmental absorption, which is useful for the development of drug delivery systems. We have demonstrated that the plasma profile of orally administered drugs can be predicted by use of gastrointestinal transit and segmental absorbability information and that this method is especially useful for estimating separately the effect of absolute absorption and first-pass metabolism on the bioavailability of drugs. 相似文献
68.
Lessons from serum cholesterol studies in Japan,Hawaii and Los Angeles 总被引:10,自引:0,他引:10
KEYS A KIMURA N KUSUKAWA A BRONTE-STEWART B LARSEN N KEYS MH 《Annals of internal medicine》1958,48(1):83-94
69.
70.
SHIN-ICHI OSARI HIDEKI MURANAKA TADASHI KOJIMA YOSHIHARU KIMURA 《Pediatrics international》1995,37(3):409-412
We describe a 6 year old girl with chorea following cardiac surgery, the first such report in Japan. The radical operation for total anomalous pulmonary venous return was carried out at the age of 11 months under hypothermia. Seven days after the operation, a sudden onset of irritability, dysphagia, chorea, generalized hypotonia, and complete external ophthalmoplegia were seen. These symptoms diminished gradually, but chorea remained. We speculated that the cause of chorea arose from the cardiac surgery under hypothermia. It is necessary to consider ‘cardiac surgery’ as one of the triggers of certain movement disorders including chorea. We tried treatment with haloperidol, pimozide, and several other drugs; only pimozide was effective in decreasing chorea without any side-effects. 相似文献