Effect of Acute and Chronic Administration of 5-FU on Pancreatic Secretion

The administration of various dose schedules of 5-FU did not result in any alteration of pancreatic secretion. The findings would not support the thesis that the gastrointestinal side-effects of this potent cancer chemotherapeutic agent are the result of a toxic pancreatic insufficiency.     

福寿草的药理学研究

福寿草Adonis amurensis Regel et Radd.为毛茛科多年生草本植物,与欧洲产已供临床应用的春福寿草Adonis vernalis L.同属。该草在我国各地野生甚多,特别是辽东沈安铁路沿綫尤多,除我国外,苏联西伯利亚东部、庫页岛、高加索等地及朝鲜,日本北部皆有此植物生长。医学上很久以前即已知福寿草是一种作用很强的药物。1880年在巴甫洛夫指导下曾对春福寿草进行了实验室观察,证明它是一种良好的洋地黄代用品。其后     

苍耳子的有毒成分及其药理作用

蒼耳(Xanthium strumarium L.)是菊科植物,别名野茄子、敞子、老蒼子(东北)及刺儿棵(河南)等,我国各地都有野生。蒼耳的果实名蒼耳子,是一味常用中药,內含油約39％,蒼耳甙(xanthostrumarin)1.27％,此外尚含树脂、生物碱和丙种維生素等。儿童与家畜誤食蒼耳的果实或幼苗可以中毒死亡。为了寻找蒼耳子的毒性成分,我所植物化学室侯翠英等将蒼耳子仁脫脂,制成水浸剂,并从中提出一种蛋白貭及一种黃白色結晶状具有甙类性貭的物貭(含葡萄糖及鼠李糖),后者暫名为AA_2。我們比較了蒼耳子油、蒼耳子水浸剂、蒼耳子蛋白及AA_2的毒性,并观察了AA_2的一些药理作用。     

DCQ—I型电动清创冲洗机研制及应用

当今社会开放性损伤极其多见 ,在其处理过程中 ,清创术是关键。为提高清创的效率 ,特研制了电动清创冲洗机 (包括洗机、清创术台 )。通过动物试验及临床初步应用证明冲洗机优于其它冲洗方法 ,清创术台功能多 ,使用简单方便     

Age at first birth, parity, and risk of death from ovarian cancer in Taiwan: a country of low incidence of ovarian cancer

This study was undertaken to examine whether there is an association between parity and age at first birth and risk of ovarian cancer. The study cohort consisted of all women with a record of a first and singleton childbirth in the Birth Register between 1978 and 1984. We tracked women from the time of their first childbirth to December 31, 2003, and their vital status was ascertained by linking records with the computerized mortality database. Cox proportional hazard regression models were used to estimate the relative risks (RR) of death from ovarian cancer associated with parity and age at first birth. There were 322 ovarian cancer deaths during 27,402,995.5 person-years of follow-up. The mortality rate of ovarian cancer was 1.18 cases per 100,000 person-years. A trend of increasing risk of ovarian cancer was seen with increasing age at first birth. The adjusted RR was 0.69 (95% CI = 0.52-0.90) for women who bore two children, and 0.30 (95% CI = 0.21-0.42) for women with three or more births, respectively, when compared with women who had given birth to only one child. There was a significant decreasing trend in the adjusted RR of ovarian cancer with increasing parity. This study provides evidence that parity may confer a protective effect on the risk of ovarian cancer.     

Syntheses and biological activities of chiral piperidines-tachykinin NK3 antagonists

ＩＮＴＲＯＤＵＣＴＩＯＮＯｖｅｒｔｈｅｌａｓｔｄｅｃａｄｅ，ｍａｊｏｒａｄｖａｎｃｅｓｈａｖｅｂｅｎｍａｄｅｉｎｕｎｄｅｒｓｔａｎｄｉｎｇｔｈｅｂｉｏｌｏｇｙｏｆｍａｍｍａｌｉａｎｔａｃｈｙｋｉｎｉｎｎｅｕｒｏｐｅｐｔｉｄｅｓ．Ｉｔｉｓｎｏｗｗｅｌｅ...     

Mechanisms of Transition Between Double Paroxysmal Supraventricular Tachycardias

INTRODUCTION: Coexistence of double tachycardias in one patient has been infrequently reported. Furthermore, the mechanisms of transition between double paroxysmal supraventricular tachycardias have not been well studied. METHODS AND RESULTS: Thirty-five patients with two paroxysmal supraventricular tachycardias were studied. Group IA consisted of 3 patients with spontaneous transition between AV reciprocating tachycardia (AVRT) and AV nodal reentrant tachycardia (AVNRT). Group IB consisted of 13 patients without spontaneous transition between AVRT and AVNRT. Group IIA consisted of 5 patients with spontaneous transition between AVNRT and atrial tachycardia (AT). Group IIB consisted of 14 patients without spontaneous transition between AVNRT and AT. The absolute values of differences between the two tachycardia cycle lengths were significantly smaller in patients with than in those without transition between the two tachycardias (25+/-8 msec vs 90+/-46 msec, P < 0.05, IA vs IB; 21+/-25 msec vs 99+/-57 msec, P < 0.01, IIA vs IIB). The cutoff point of 25 msec had 80% positive predictive value for transition between the two tachycardias. Transition between two tachycardias occurred due to a spontaneous premature atrial complex (30%), conduction block at one limb of tachycardia (20%), or tachycardia-induced tachycardia (50%). Absence of transition between two tachycardias might be explained by the absence of a spontaneous premature atrial complex, longer cycle length of the first tachycardia, larger difference between two tachycardia cycle lengths, or induction of each tachycardia under different situations. CONCLUSION: Double supraventricular tachycardias with similar tachycardia cycle lengths are vulnerable to transition between different tachycardias.