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缩氨基硫脲及其过渡金属络合物的合成与抗菌活性 总被引:10,自引:0,他引:10
本文设计合成了8种缩氨基硫脲化合物及其12种过渡金属络合物,并进行了抑菌实验。结果表明:芳醛(酮)的邻位存在杂原子或取代基团为其缩氨基硫脲活性表现必不可少的结构因素。络合物的抑菌活性一般较缩氨基硫脲本身高,二者遵循不同的抑菌机制。 相似文献
94.
The appearance of the vagina was evaluated on magnetic resonance (MR) images of 65 subjects who were healthy or had disease unrelated to the vagina and 24 patients with suspected congenital anomalies of the vagina. MR imaging accurately demonstrated the presence of (n = 78) or complete (n = 7) or partial (n = 4) absence of the vagina in each case. Partial (n = 2) or complete (n = 2) duplication of the vagina was also correctly diagnosed. Regardless of field strength, T2-predominant images were essential for evaluation. The transverse plane was optimal, and a 5-mm section thickness was preferable. Estrogen stimulation affected the appearance of the vagina: The contrast between the vaginal wall and the central mucus-containing area was greatest during the early proliferative and late secretory phases. MR imaging offers unique depiction of congenital anomalies and should be used when results of physical examination or other radiologic studies, such as ultrasound, are inconclusive. 相似文献
95.
1-乙基-6-氟-1,4-二氢-4-氧-7-(4-对硝基苯甲酰基-1-哌嗪基)喹啉-3-羧酸及其类似物的合成 总被引:1,自引:0,他引:1
Syntheses of thirteen new compounds of 1-ethyl-6-flouro-1, 4-dihydro-4-oxo-7-[(4-p-nitrobenzoyl)1-piperazinyl] quinoline-3-carboxylic acid and its analogues are reported. The structures were determined by IR, 1HNMR and elemental analysis. Four compounds have been subjected to antibacterial activity tests in vitro. Compound I1 was shown to have significant activity. 相似文献
96.
Vagina: evaluation with MR imaging. Part II. Neoplasms 总被引:1,自引:0,他引:1
The potential of magnetic resonance (MR) imaging in the detection of vaginal tumors and the assessment of their extent was evaluated retrospectively in 87 patients in whom primary, metastatic, or recurrent vaginal cancer was clinically suspected. MR findings were compared with the results of surgery and/or biopsy. Results of histopathologic study verified a normal vagina in 51 patients, benign cysts in two, primary tumor in four, metastatic cancer in 22, and recurrent tumor in eight. MR imaging demonstrated the two benign cysts, correctly depicting their size and location, and demonstrated and enabled correct staging of the four primary tumors. MR accuracy for demonstrating metastatic cancer was 92%, sensitivity was 95%, and specificity was 90%. Tumor extension to the vagina was reliably excluded (negative predictive value = 97%), but false-positive interpretations occurred (positive predictive value = 84%) primarily because inflammation (n = 2) and congestion (n = 2) could not be distinguished from tumor invasion. An additional role of MR imaging was the ability to differentiate tumor from fibrotic tissue in patients with suspected recurrent vaginal carcinoma. The overall accuracy of MR imaging for recurrent vaginal cancer was 82% (14 of 17). 相似文献
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β-受体阻断药在心血管病的治疗中占有相当重要的地位,对缺血性心脏病有肯定的疗效。但也存有不良反应或禁忌症,其中有的是由于其选择性不高所致。因此,寻找特异性的β_1受体阻断药是目前研究抗心肌缺血药的一个重要方面。据报道,在β-受体阻断药的基本有效结构的苯环的对位与4(3H)-喹唑酮环的2位 相似文献
100.
Kung FT; Chang SY; Tsai YC; Hwang FR; Hsu TY; Soong YK 《Human reproduction (Oxford, England)》1997,12(3):591-595
The case reports of 22 patients with cervical pregnancies treated by
methotrexate (MTX) administration and published in English literature
between 1983 and 1995 were reviewed, by either original paper review or
follow-up under international collaboration, to determine the subsequent
reproductive performance and obstetric outcomes. Out of 22 cases, 18 (78%)
MTX chemotherapy attempts succeeded with complete remission and four (22%)
failed. Of the 13 women who wished to conceive and could be followed for at
least 3 years, nine succeeded in having live births without congenital
malformations, one spontaneously aborted and three suffered infertility. In
general, MTX chemotherapy alone or combined with adjuvant methods such as
subsequent cervical curettage or cervical tamponade, or intracervical
potassium chloride injection, appears to be a convenient and effective
method for the treatment of the majority of cervical pregnancies before 12
weeks gestation, and has not been shown to have detrimental effects on
subsequent reproductive capacities, obstetric outcomes and progeny health
for those cases with successful preservation of the uteri.
相似文献