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111.
Background
Plants containing compounds such as the isoflavonoids, with female hormone-like effects that bind to human estrogen receptors, are known. But none has been previously shown to have corresponding male hormone-like effects that interact with the human androgen receptor. Here, we report that the tree bark (cortex) of the Gutta-Percha tree Eucommia ulmoides possesses bimodal phytoandrogenic and hormone potentiating effects by lipidic components. 相似文献112.
溶血曼氏杆菌常引起哺乳类动物呼吸道感染,偶可致人类呼吸道感染及败血症。其生物型A血清型1(A1)是主要的致病菌,临床表现有发热、咳嗽、鼻腔分泌物增多、呼吸窘迫,该菌引起的疾病病死率高,但发病机制尚不明确。了解其致病机制对研制疫苗、制备快速诊断试剂,以达到预防、快速诊断及治疗目的有重要意义。 相似文献
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用标记的血小板活化因子拮抗剂[~3H]WEB 2086,在培养的牛脑前动脉平滑肌细胞上鉴定了血小板活化因子受体。结果表明在25℃时该细胞上存在两种与配基具有不同亲和力的受体结合位点,其中K_(d-1)=22.8±5.0 nmol·L~(-1),K_(d-2)=186+20.5 nmol·L~(-1);B_(max-1)=2.1±0.3 pmol/10~4细胞,B_(max-2)=12.1±1-5 pmol/10~6细胞。蝙蝠葛碱和粉防己碱均能抑制[~3H]WEB2086与上述细胞的结合。 相似文献
116.
In order to search for effective antimyocardial ischemic agents, fourteen new 3 4-[(3-alkylamino-2-hydroxy)propoxy] phenyl(benzyl)]-substituted 4(3H)-quin zolinones (Ⅱ) were synthesized. Substituted o-aminobenzoic acids used as the starting materials were allowed to react with acetic anhydride and then p-aminophenol (method A), or with N- (4- hydroxyphenyl)formamide (method B), or with thionyl chloride and then N - (4 - hydroxybenzyl) formamide (methode C) to form 3-[(4-hydroxyphenyl(benzyl)]-substituted 4(3H)-quinazolinones (Ⅲ). The intermediate Ⅲ reacted with epichiorohydrin to form the epoxides (Ⅳ). The reaction of Ⅳ with an excess of isopropylamine or tert-butylamine in boiling chloroform gave the desired products. Of all the compounds synthesized, Compounds Ⅱ3~5 and Ⅱ13 were found to increase the tolerance of mice to hypoxia. Further evaluation is in progress. 相似文献
117.
AbstractThis paper summarizes findings from a population study on outcomes of children with hearing loss in Australia, the Longitudinal Outcomes of Children with Hearing Impairment (http://www.outcomes.nal.gov.au) study. Children were evaluated at several intervals using standardized tests, and the relationship between a range of predictors and the outcomes was examined. This paper reports the performance of children with cochlear implants at 5 years of age together with factors predicting word reading ability. Earlier age at cochlear implantation was significantly associated with better word reading ability, after controlling for the effects of language, receptive vocabulary, nonverbal cognitive ability, and device configuration. 相似文献
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BACKGROUND:
Endovascular repair of mycotic aneurysm is an alternative to open repair if the patho-anatomy is suitable. The aortic size above and below the mycotic aneurysm may be small.METHODS:
A retrospective review was made of prospectively collected departmental computerised database.RESULTS:
Three oriental patients with juxta- and infra-renal mycotic aortic aneurysms with a small aortic diameter of 17 mm to 18 mm underwent successful emergency endovascular treatment using Cook® Zenith ESLE stentgrafts. These are ancillary devices aimed at iliac extensions usually.CONCLUSION:
This is to our knowledge the first case series of Cook® Zenith ESLE iliac component endografts for the treatment of aortic mycotic aneurysms with small aortae, and short- and mid-term results are encouraging.KEY WORDS: Endovascular, Mycotic, Small aorta, Oversizing, Cook®, Zenith ESLE Stentgrafts 相似文献120.
Caffeine inhibits the viability and osteogenic differentiation of rat bone marrow-derived mesenchymal stromal cells 总被引:1,自引:0,他引:1
Y Zhou XX Guan ZL Zhu J Guo YC Huang WW Hou HY Yu 《British journal of pharmacology》2010,161(7):1542-1552