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31.
MICHIKO KAJIWARA YUKI YAMAGUCHI KANJI HIRAI JUNICHI YATA 《Pediatrics international》1993,35(5):387-393
Human cytomegalovirus (HCMV) is one of the most important agents causing opportunistic infections in immunocompromised hosts. In this study, we examined the urinary excretion of HCMV in children with malignancy using polymerase chain reaction (PCR). Urine samples were collected from on-therapy, off-therapy patients with malignancy, and healthy controls. A simple DNA extraction method using glass powder was employed, and inhibitory effect of urine on PCR was prevented. For PCR, a pair of primers from the HCMV major immediate early gene sequence was used. Among patients who received intensive chemotherapy, 52.0% had urinary HCMV excretion after the chemotherapy course. In contrast, off-therapy patients and healthy controls showed a lower incidence of urinary HCMV excretion (20.4 and 8.7%, respectively). The incidence of HCMV urinary excretion in the on-therapy group was significantly higher than healthy controls (P < 0.05). In the on-therapy group, the total white blood cell count of the virus excreters was lower than that of non-excreters. The incidence of HCMV excretion was high in on-therapy patients. Most of the virus excreters were seropositive, so their viruria was thought to be caused by reactivation. Repeated monitoring of virus excretion by this rapid and simple method may be useful to detect HCMV infection early and to control it in such patients. 相似文献
32.
Osamu OWA Taiji AKAMATSU Yoshiaki MATSUDA Keisuke MATSUO Osamu HASEBE Hiroyasu USHIMARU Kenji MUKAWA Toshikazu KAMIJO Yoshifumi FUJIMORI Seiicii FURUTA Tamie NASU Akio SATO Kotaro YAMAGUCHI 《Digestive endoscopy》1991,3(4):560-564
Abstract: A 64-year-old male lens grinder with a 43-year history of occupational exposure to trichloroethylene (TCE) visited Shinshu University Hospital in December 1988 complaining of distention of the lower abdomen. A barium enema study and endoscopic examination showed rosary-like semilunar folds and edematous mucosa of undetermined etiology in the sigmoid colon. Three months later, the patient visited the hospital again complaining of blood in the stool. An endoscopic examination performed at this time revealed numerous broad-based, smooth-surfaced, protruding lesions in the sigmoid colon. A diagnosis of pneumatosis cystoides intestinalis (PCI) associated with TCE was made. After 4-days treatment with 50% oxygen given by inhalation, the patient's symptoms were completely relieved, and a colonoscopy revealed no evidence of PCI. He returned to his job at the factory which involved dealing with TCE and because of adequate ventilation and a shorter work-day he has been free of recurrence during a year follow-up period. The finding of rosary-like semilunar folds, as demonstrated by the initial endoscopic and barium enema studies in our patient, is a peculiar one in the incipient stage of PCI. 相似文献
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34.
RYO YAMASHITA RAIZOU YAMAGUCHI KEIJI YUEN MASASHI NIWAKAWA KENICHI TOBISU 《International journal of urology》2006,13(11):1448-1450
The case is reported of urothelial carcinoma (clear cell variant) that was diagnosed with useful immunohistochemistry stain. A 70-year-old man, who had undergone left radical nephrectomy for renal cell carcinoma in August 2003 and partial lobectomy for pulmonary metastasis in May 2005, complained of hematuria in June 2005. On evaluation, a papillary pedunculated tumor was detected in the left wall of the urinary bladder. A transurethral resection of the bladder tumor (TUR-Bt) was performed in July 2005. The pathological diagnosis was difficult due to diffuse clear cell appearance. Immunohistochemistry stain showed urothelial carcinoma, not metastasis of the renal cell carcinoma. Finally it was diagnosed as urothelial carcinoma clear cell variant. Urothelial carcinoma has many variants that show a variety of appearances and characteristics. These should be well known before medical therapy is initiated. 相似文献
35.
ATSUYUKI KOHARA MASAMICHI OKADA RIE TSUTSUMI KAZUSHIGE OHNO MASAYASU TAKAHASHI MASAO SHIMIZU-SASAMATA JUN-ICHI SHISHIKURA HIROSHI INAMI SHUICHI SAKAMOTO TOKIO YAMAGUCHI 《The Journal of pharmacy and pharmacology》1998,50(7):795-801
The in-vitro pharmacological properties of (2,3-dioxo-7-(1H-imidazol-***1-yl)-6-nitro-1,2,3,4-tetrahydro-1-quinoxalinyl)-acetic acid monohydrate, YM872, a novel and highly water-soluble α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)-receptor antagonist were investigated. YM872 is highly water soluble (83 mg mL?1 in Britton-Robinson buffer) compared with 2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo(F)quinoxaline (NBQX), 6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione hydrochloride (YM90K) or 6-cyano-7-nitroquinoxa-line-2,3-dione (CNQX). YM872 potently inhibits [3H]AMPA binding with a Ki (apparent equilibrium dissociation constant) value of 0.096 ± 0.0024 μM. However, YM872 had very low affinity for other ionotropic glutamate receptors, as measured by competition with [3H]kainate (high-affinity kainate binding site, concentration resulting in half the maximum inhibition (IC50) = 4.6 ± 0.14 μm), [3H]glutamate (N-methyl-D-aspartate (NMDA) receptor glutamate binding site, IC50 > 100 μM) and [3H]glycine (NMDA receptor glycine-binding site, IC50 > 100 μM). YM872 competitively antagonized kainate-induced currents in Xenopus laevis oocytes which express rat AMPA receptors, with a pA2 value of 6.97 ± 0.01. In rat hippocampal primary cultures, YM872 blocked a 20-μM AMPA-induced increase of intracellular Ca2+ concentration with an IC50 value of 0.82 ± 0.031 μM, and blocked 300-μM kainate-induced neurotoxicity with an IC50 value of 1.02 μM. These results show that YM872 is a potent and highly water-soluble AMPA antagonist with great potential for treatment of neurodegenerative disorders such as stroke. 相似文献
36.
MASAKO YAMAGUCHI SEIICHIRO KAMIMURA JUNICHI TAKADA KAORU IWATA TAKESHI IIDA KAZUO KOBAYASHI HAJIME NAKANO YASUHIRO OKADA SATORU FUJIIMI TETSURO SOHDA NAOMI HIZUKA 《Journal of gastroenterology and hepatology》1998,13(1):47-51
This case of hepatocellular carcinoma (HCC) with alcoholic liver fibrosis, which was not associated with hepatitis viruses, was accompanied by hypoglycaemia. The immunoreactive insulin level was low and other hormonal examinations were almost normal. Immunohistochemical studies showed a high level of insulin-like growth factor II (IGF2) peptide in the HCC section and the size heterogeneity of serum IGF2 investigated by western blot revealed a large form at approximately 15 kDa. These results suggest that the HCC with alcoholic liver fibrosis produced IGF2 and that the hypoglycaemia was caused by tumour-associated IGF2. 相似文献
37.
38.
Hiroyuki WATANABE Ikurou MOURI Yasushi YAMAGUCHI Osamu YAMAKAWA Hiroyasu KAWAKAMI Yoshitake SATOMURA Hideki Ohta Yoshiharu MOTOO Takashi OKAI Masanori FUKUI Norio SAWABU 《Digestive endoscopy》1992,4(2):139-146
Abstract: This study was undertaken to assess the diagnostic significance of the colon mucus test (CMT) by which the cancer-associated carbohydrate antigen, β-D-Gal (1 - 3)-D-GalNAc (T antigen) is measured in rectal mucus, chiefly in patients with various alimentary tract diseases. The incidence of a positive CMT was relatively high in colorectal cancer (69%) and gastric cancer (40%), and was similarly high in some benign colorectal diseases such as colonic diverticulum (42%) and colonic polyps (39%), and in gastric polyps (75%). On the other hand, the incidence of a positive CMT in other benign diseases or in healthy controls was less than 10%. A positive CMT was significantly more common in colorectal disease and in gastric tumors (cancer and polyps) than in the other diseases (p < 0.001). Of 28 colonic polyp patients, 20 (71%) had negative fecal occult blood test results (FOBT), and nine of them (45%) had positive CMT results. These results suggest that the CMT may be a useful screening test for alimentary tract disease, particularly colorectal disease and gastric tumors, although its specificity for colorectal cancer is only moderate. Furthermore, a combination assay using FOBT plus CMT may help to improve the diagnostic rate. 相似文献
39.
Brief Psychotherapy of a Grief Reaction* 总被引:1,自引:1,他引:0
Takashi YAMAGUCHI M.D. 《Psychiatry and clinical neurosciences》1970,24(4):227-237
A patient suffering from a grief reaction treated by brief psychotherapy is described. Several factors contributed to her grief, among them termination with her former psychotherapist without sufficient working through of this separation. The nature of the brief psychotherapy is outlined as well as a follow-up interview by an independent observer. 相似文献
40.
YOSHIMORI MASAYOSHI; OKAZAKI NOBUO; YOSHIDA SHIGEAKI; TAJIRI HISAO; YAMAGUCHI HAJIME; HIROTA TERUYUKI 《Japanese journal of clinical oncology》1982,12(2):285-292
Tegafur, 1-(2-tetrahydrofuryl)-5-fluorouracil, was administeredin combination with uracil to two patients with carcinoid tumorof the stomach and the effect of the drug was evaluated. The first patient was a 67-yr-old woman. She was admitted becauseof an upper abdominal tumor. Exploratory laparotomy revealeda gastric tumor and an additional huge tumor with liver metastasisand peritoneal dissemination. Histological examination of biopsyspecimens from the gastric tumor and metastatic lesions revealedcarcinoid tumor. Tegafur and uracil were coad-ministered postoperatively.During three months of treatment the gastric tumor improvedendoscopically and the large abdominal tumor decreased from10x10 cm to 4x4 cm. The second patient was a 55-yr-old man. He was admitted becauseof severe diarrhea. Biopsy from a gastric lesion and metastaticskin lesions revealed carcinoid tumor. After coadministrationof tegafur and uracil and mitomycin C, the metastatic skin lesionsbecame smaller and some of the lesions disappeared. The liveralso decreased in size. These two cases suggest the possibility that coadministrationof tegafur and uracil may be effective for carcinoid tumor ofthe stomach. 相似文献