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991.
992.
993.
Vincent Goëb Fabienne Jouen Danièle Gilbert Xavier Le Loët François Tron Olivier Vittecoq 《Joint, bone, spine : revue du rhumatisme》2009,76(4):343-349
The diagnosis of rheumatoid arthritis (RA) must be made early, because prompt initiation of treatments tailored to disease activity is crucial to improve structural and functional outcomes. Anti-citrullinated peptide antibodies (ACPAs) are well-established diagnostic markers for RA and should be included in the classification criteria. Here, we describe the main tests for detecting ACPAs and we underline the diagnostic and prognostic usefulness of ACPAs in patients with RA. The presence of ACPAs predicts poorer functional and structural outcomes, and ACPA titers respond to some of the medications used in RA. Therefore, ACPA titers should be determined at regular intervals throughout follow-up. 相似文献
994.
Nathalie Auger Ernest Lo Michael Cantinotti Jennifer O'Loughlin 《Addiction (Abingdon, England)》2010,105(12):2176-2183
Aims To determine if impulsivity and socio‐economic status (SES) interact to influence gambling onset in youth. Design Longitudinal study of grade 7 students followed for 8 years. Setting Montréal, Canada. Participants A total of 628 adult students aged 12.6 years on average at cohort inception. Measurements Impulsivity and SES (parent education, area deprivation) were collected during secondary school. Age of gambling onset was collected retrospectively when participants were aged 20.3 years. Cox proportional hazards regression was used to model the association between time to first report of gambling and interaction terms for each of impulsivity and parent education, and impulsivity and area deprivation accounting for sex and ethnicity. Findings Median (interquartile range) age of gambling onset was 17.0 (4.0) years. Impulsivity independently increased the risk of gambling onset among participants with no university‐educated parent [hazard ratio (HR) 1.3; 95% confidence interval 1.1–1.5] and those living in highly deprived areas (HR 1.7; 1.5–2.0). Impulsivity was not associated with gambling onset among high SES youth. Among participants with high impulsivity, risks were elevated for those with no university‐educated parent relative to one or more university‐educated parent (HR 1.7; 1.1–2.7), and for participants living in deprived relative to advantaged areas (HR 5.0; 2.6–9.6). SES was not associated with gambling onset among participants with low impulsivity. Conclusions Impulsivity is a risk factor for gambling onset among low but not high SES youth, and low SES influences gambling onset primarily among impulsive youth. Gambling prevention programmes may need to consider potential interaction between impulsivity and SES. 相似文献
995.
Reduction of tissue plasminogen activator-induced hemorrhage and brain injury by free radical spin trapping after embolic focal cerebral ischemia in rats. 总被引:14,自引:0,他引:14
Thrombolytic stroke therapy with tissue plasminogen activator (tPA) remains complicated by serious risks of cerebral hemorrhage and brain injury. In this study, a novel model of tPA-induced hemorrhage was used in spontaneously hypertensive rats to examine the correlates of hemorrhage, and test methods of reducing hemorrhage and brain injury. Homologous blood clot emboli were used to occlude the middle cerebral artery in spontaneously hypertensive rats, and delayed administration of tPA (6 hours postischemia) resulted in high rates of cerebral hemorrhage 24 hours later. Compared with untreated rats, tPA significantly increased hemorrhage volumes by almost 85%. Concomitantly, infarction and neurological deficits were worsened by tPA. A parallel experiment in normotensive Wistar-Kyoto rats showed markedly reduced rates of hemorrhage, and tPA did not significantly increase hemorrhage volumes. To examine whether tPA-induced hemorrhage was caused by the delayed onset of reperfusion per se, another group of spontaneously hypertensive rats was subjected to focal ischemia using a mechanical method of arterial occlusion. Delayed (6 hours) reperfusion via mechanical means did not induce hemorrhage. However, administration of tPA plus delayed mechanical reperfusion significantly increased hemorrhage volumes. Since reperfusion injury was implicated, a final experiment compared outcomes in spontaneously hypertensive rats treated with tPA plus the free radical spin trap alpha-phenyl tert butyl nitrone (alpha-PBN) versus tPA alone. tPA-induced hemorrhage volumes were reduced by 40% with alpha-PBN, and infarction and neurological deficits were also decreased. These results indicate that (1) blood pressure is an important correlate of tPA-induced hemorrhage, (2) tPA interacts negatively with reperfusion injury to promote hemorrhage, and (3) combination therapies with anti-free radical treatments may reduce the severity of tPA-induced hemorrhage and brain injury after cerebral ischemia. 相似文献
996.
997.
V. Di Lazzaro D. Restuccia M. Lo Monaco M. Milone P. Tonali 《The Italian Journal of Neurological Sciences》1990,11(3):309-312
Here we report median and common peroneal nerve SEPs in a patient with tabes dorsalis. SEPs were within normal limits following
median nerve stimulation, but of prolonged latency for common peroneal nerve. This was in keeping with clinical findings of
posterior column involvement confined to the lumbosacral tract and with pathological features of tabetic neurosyphilis.
Sommario Gli autori riportano le caratteristiche dei potenziali evocati somatosensoriali del nervo mediano e peroneo comune in un paziente affetto da tabe dorsale. I potenziali evocati somatosensoriali sono risultati nei limiti della norma stimolando il nervo mediano ma di latenza aumentata per il nervo peroneo comune. Ciò risultava in accordo sia con le caratteristiche cliniche di segni di interessamento dei cordoni posteriori limitato al tratto lombosacrale che con le caratteristiche anatomopatologiche della neurosifilide.相似文献
998.
Jiin-Haur Chuang M.D. Shin-Yi Lee M.D. Wei-Jen Chen M.D. Chie-Song Hsieh M.D. Nyuk-Kong Chang D.V.M. Sing-Kai Lo Ph.D. 《World journal of surgery》2001,25(12):1512-1518
Postoperative cholangitis is a frequent
and unpredictable complication of unknown etiology following bile duct
reconstruction (BDR), particularly for biliary atresia. This study was
undertaken to correlate the growth of bacteria in the
hepaticojejunostomy with that in the liver after BDR. Quantitative
bacterial culture was done on the specimens taken from the liver and
from the hepaticojejunostomy at 1 week (group 1, n = 7), 1 month
(group 2, n = 7), and 2 months (group 3, n = 7) following BDR
with Roux-en-Y hepaticojejunostomy in piglets after 2 weeks of common
bile duct ligation. The histological examination of the liver and the
hepaticojejunostomy, as well as serial monitoring of hemogram and liver
function tests, were performed to correlate the findings with the
bacterial concentration of the liver and the hepaticojejunostomy
following BDR. The bacterial concentration of the hepaticojejunostomy,
expressed as log10 colony-forming units per gram
(log10 CFU/g) of the hepaticojejunostomy, showed a
progressive decrease from 8.38 ± 1.36 in group 1, 7.07 ±
2.54 in group 2, to 3.56 ± 1.31 in group 3 (p =
0.001). The log10 CFU/g of the liver also showed a
progressive decrease from 5.02 ± 1.59 in group 1, 3.16 ±
1.56 in group 2, to 2.19 ± 1.09 in group 3 (p =
0.006). There was a significant positive correlation of the
log10 CFU/g of the liver (n = 21) with that of the
hepaticojejunostomy (n = 21) following BDR (r = 0.600,
p = 0.004). Most of the infectious pathogens isolated
from the liver were also isolated from the hepaticojejunostomy. The
changes in hemoglobin, bilirubin, albumin, and ammonia significantly
correlated with the changes of the bacterial concentration of the
liver. The results of the study suggests that hepatic bacterial
proliferation after BDR is significantly affected by microbial
overgrowth in the bilioenteric anastomosis and is associated with
deteriorated liver function and hemogram. 相似文献
999.
1000.
Pancreatic Solid-cystic-papillary Tumor: Clinicopathologic Features in Eight Patients from Hong Kong and Review of the Literature 总被引:43,自引:1,他引:42
Solid-cystic-papillary tumors (SCPTs) of the pancreas are rare. The clinicopathologic features and pathogenesis of these
tumors have attracted a number of investigations, but the results remain unclear. We investigated the clinicopathologic data,
immunohistochemical expression of the pan-endocrine markers, hormones, steroid receptors, and p53 overexpression in pancreatic
SCPTs from eight Chinese patients (seven women, one man) collected over a 24-year period. They accounted for 2.5% of the primary
pancreatic tumors. The tumors were seen in young women (mean age 27 years). They were large (mean size of resected tumor was
8.4 cm), benign, had solid and cystic areas, and were evenly distributed in the pancreas. The main differential diagnosis
was pancreatic endocrine tumor. The tumors were negative for pan-endocrine markers, hormones, estrogen receptor, progesterone
receptor, and p53. To date, 452 pancreatic SCPTs have been documented in the English literature. They occurred in patients
of different ethnic groups, particularly in non-Caucasians. The tumors were frequently noted in young females. Uncommon cases
of malignant pancreatic SCPTs were often found in older men and had indolent behavior. It was concluded that pancreatic SCPTs
have distinct clinicopathologic characteristics. The present observations, together with a review of the literature suggests
that overexpression of p53 or estrogen receptor is not important in the pathogenesis of pancreatic SCPTs. 相似文献