全文获取类型
收费全文 | 432778篇 |
免费 | 30205篇 |
国内免费 | 6572篇 |
专业分类
耳鼻咽喉 | 5631篇 |
儿科学 | 9268篇 |
妇产科学 | 10657篇 |
基础医学 | 58223篇 |
口腔科学 | 12642篇 |
临床医学 | 37657篇 |
内科学 | 85240篇 |
皮肤病学 | 9127篇 |
神经病学 | 29430篇 |
特种医学 | 15656篇 |
外国民族医学 | 108篇 |
外科学 | 64818篇 |
综合类 | 21351篇 |
现状与发展 | 7篇 |
一般理论 | 70篇 |
预防医学 | 22258篇 |
眼科学 | 10679篇 |
药学 | 37863篇 |
53篇 | |
中国医学 | 6272篇 |
肿瘤学 | 32545篇 |
出版年
2022年 | 3313篇 |
2021年 | 5244篇 |
2020年 | 3817篇 |
2019年 | 4330篇 |
2018年 | 6239篇 |
2017年 | 5227篇 |
2016年 | 5130篇 |
2015年 | 6617篇 |
2014年 | 8924篇 |
2013年 | 10506篇 |
2012年 | 14756篇 |
2011年 | 15360篇 |
2010年 | 10001篇 |
2009年 | 8947篇 |
2008年 | 12950篇 |
2007年 | 13537篇 |
2006年 | 13233篇 |
2005年 | 11943篇 |
2004年 | 10627篇 |
2003年 | 10147篇 |
2002年 | 9482篇 |
2001年 | 29209篇 |
2000年 | 29615篇 |
1999年 | 24495篇 |
1998年 | 5653篇 |
1997年 | 4774篇 |
1996年 | 4203篇 |
1995年 | 3789篇 |
1994年 | 3363篇 |
1993年 | 3024篇 |
1992年 | 16244篇 |
1991年 | 14959篇 |
1990年 | 14286篇 |
1989年 | 14087篇 |
1988年 | 12667篇 |
1987年 | 12166篇 |
1986年 | 11169篇 |
1985年 | 10379篇 |
1984年 | 6961篇 |
1983年 | 5622篇 |
1982年 | 2734篇 |
1979年 | 5491篇 |
1978年 | 3366篇 |
1977年 | 2982篇 |
1975年 | 2647篇 |
1974年 | 3076篇 |
1973年 | 2872篇 |
1972年 | 2829篇 |
1971年 | 2777篇 |
1969年 | 2548篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
11.
目的探究面肌痉挛患者微血管减压术(MVD)中异常肌反应(AMR)的变化特点与术后疗效的关系。方法回顾性分析73例MVD术中采用AMR全程定量化监测患者的AMR变化特点,减压操作前AMR阈值较基础阈值升高≥1倍为A1组、1倍为A2组,手术结束时AMR完全消失为B1组、未消失为B2组,B2组中AMR阈值较基础阈值升高≥1倍为B2a组、1倍为B2b组,对各组的术后疗效进行对比分析。结果 A1组21例中,19例立即治愈,1例延迟治愈,1例未愈; A2组52例中,35例立即治愈,9例延迟治愈,8例未愈。A1组较A2组疗效好(P=0. 046)。B1组50例中,42例立即治愈,5例延迟治愈,3例未愈; B2组23例中,12例立即治愈,5例延迟治愈,6例未愈。B1组较B2组疗效好(P=0. 003)。B2 a组的治愈比例较B2 b组高(分别为14/16、3/7),差异有统计学意义(P=0. 045)。结论 AMR在术中的变化特点对术者有重要参考意义,AMR在减压前升高、在手术结束时完全消失、未消失但升高较基础阈值≥1倍者术后疗效相对较好。 相似文献
12.
13.
We report a Chinese family with members affected by epidermolytic ichthyosis (EI), caused by KRT gene mutations. The proband was a 14‐year‐old boy who had simultaneous appearance of nephroblastoma and epidermolytic ichthyosis (EI). Both the patient and his mother exhibited the specific clinical and pathological manifestations of EI. We analysed all exons and flanking sequences of the KRT1 and KRT10 genes using PCR, and found that the proband and his mother had a G>C transition at nucleotide position 1432 in exon 7 of KRT1, resulting in an amino acid substitution of glutamate (GAA) to glutamine (CAA) at codon 478 (E478Q). The KRT10 gene had no mutations. 相似文献
14.
Autoimmune comorbid diseases associated with lichen planus: a nationwide case–control study
下载免费PDF全文
![点击此处可从《Journal of the European Academy of Dermatology and Venereology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
15.
Loss‐of‐function mutations in the gene encoding filaggrin underlie a Japanese family with food‐dependent exercise‐induced anaphylaxis
下载免费PDF全文
![点击此处可从《Journal of the European Academy of Dermatology and Venereology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
16.
Y.R. Song B. Wu Y.T. Yang J. Chen L.J. Zhang Z.W. Zhang H.Y. Shi C.L. Huang J.X. Pan P. Xie 《Brazilian journal of medical and biological research》2015,48(11):973-982
Bipolar disorder (BD) is a common psychiatric mood disorder affecting more than 1-2%
of the general population of different European countries. Unfortunately, there is no
objective laboratory-based test to aid BD diagnosis or monitor its progression, and
little is known about the molecular basis of BD. Here, we performed a comparative
proteomic study to identify differentially expressed plasma proteins in various BD
mood states (depressed BD, manic BD, and euthymic BD) relative to healthy controls. A
total of 10 euthymic BD, 20 depressed BD, 15 manic BD, and 20 demographically matched
healthy control subjects were recruited. Seven high-abundance proteins were
immunodepleted in plasma samples from the 4 experimental groups, which were then
subjected to proteome-wide expression profiling by two-dimensional electrophoresis
and matrix-assisted laser desorption/ionization-time-of-flight/time-of-flight tandem
mass spectrometry. Proteomic results were validated by immunoblotting and
bioinformatically analyzed using MetaCore. From a total of 32 proteins identified
with 1.5-fold changes in expression compared with healthy controls, 16 proteins were
perturbed in BD independent of mood state, while 16 proteins were specifically
associated with particular BD mood states. Two mood-independent differential
proteins, apolipoprotein (Apo) A1 and Apo L1, suggest that BD pathophysiology may be
associated with early perturbations in lipid metabolism. Moreover, down-regulation of
one mood-dependent protein, carbonic anhydrase 1 (CA-1), suggests it may be involved
in the pathophysiology of depressive episodes in BD. Thus, BD pathophysiology may be
associated with early perturbations in lipid metabolism that are independent of mood
state, while CA-1 may be involved in the pathophysiology of depressive episodes. 相似文献
17.
18.
Shasha Yuan Fang Wang Yan Zhao Yun Liu 《The International journal of health planning and management》2020,35(1):e196-e209
Since the new round of health care reform in 2009, the vertical integration of hospitals and primary health institutions has become widely implemented in China as an efficient method for improving quality of primary care. This study aimed to answer the following questions: (a) What is the perceived quality of township health centres (THCs) under integration? (B) What differences could be observed among the three typical integration models, namely, private hospital-THC integration, public hospital-THC integration, and loose collaboration? Two rounds of cross-sectional surveys were conducted from November 2016 to June 2018. The Chinese version of the Primary Care Assessment Tool was used to evaluate perceived quality of sample THCs, and 1118 adult patients were interviewed in total. Multiple linear regressions were employed to compare the quality scores between two survey rounds and among different integration models after controlling for potential confounders. The results revealed that the quality of care significantly improved under private hospital-THC integration as observed by comparing two survey rounds, while no change or slight changes were observed in the other two models. The difference observed among the three models was that the perceived quality of THCs integrated with private hospitals was worse than that of THCs integrated with public hospitals and THCs under loose collaboration, while no significant difference was observed between public hospital-THC integration and loose collaboration. Increased attention should be given to highlighting the tight integration between hospitals and THCs and the different roles played by private and public hospitals in the current reform. 相似文献
19.
20.
Yaqian Li Jingjing Yu Yun Kuang Chengkun Wu Liu Yang Qiulian Fang 《Current medical research and opinion》2020,36(9):1433-1439
Abstract