肺动脉支气管成形重建术治疗期非小细胞肺癌

目的 :为了提高 期非小细胞肺癌的手术切除率 ,减少全肺切除率并获得与全肺切除相同的手术彻底性。方法 :用肺动脉成形同时行支气管成形术治疗 期非小细胞肺癌 1 9例 ,其中鳞癌1 3例 ,腺癌 6例。左上叶袖状切除 1 1例 ,右上叶 6例 ,右中上叶 2例。结果 :本组无手术死亡 ,术后1例发生支气管胸膜瘘 ,余 1 8例无并发症 ,术后 1年及 3年生存率分别为 83%和 39%。结论 :肺动脉支气管成形重建术的应用最大限度地切除了肿瘤组织 ,并最大限度地保留了肺功能     

荷叶大豆及其合剂调脂活性部位的研究

目的：通过体内外实验探讨荷叶大豆调脂的活性部位及其作用特点,方法：以急性高脂血症小鼠为整体模型观察药物对血清胆固醇及甘油三酯的影响,体外给药观察药物对肝细胞合成胆固醇的影响。结果：荷叶大豆的水提取部分及其生物碱和黄酮均有调脂作用,大豆黄酮对体外肝细胞合成胆固醇有抑制的趋势。结论：荷叶和大豆均有调脂作用,其主要活性部位在黄酮和生物碱,其作用特点在于促进胆固醇的代谢方面。     

Effects of intrinsic nitric oxide on the expression of interleukin-4 and IFN-γ mRNA in the bronchial and lung tissues of sensitized rats

Summary To investigate the effects of intrinsic nitric oxide (NO) on the expression of interleukin-4 (IL-4) mRNA and interferon-γ (IFN-γ) mRNA in the airway inflammation of asthma, the rat models of asthmatic inflammaiton were established by sensitizing and then challenging the animals with ovalbumin. The 24 animals were randomly divided into control group, sensitized group, sensitized and L-Arg-treated group as well as L-NAME-treated group equally. By using in situ hybridization combined with compute physiological quantitative imaging analysis techniques, the influence of intrinsic NO on the expression of IL-4 mRNA and IFN-γ mRNA in the airway inflammatory cells was observed. In situ hybridization study demonstrated that IL-4 mRNA expression was obviously increased as compared with that in the control group, mainly distributed in the inflammatory cells in the submucous of airways in the sensitized group. The increase of intensity of IL-4 mRNA expression was positively correlated with the numbers of eosinophil (Eos) and lymphocyte (both with P < 0.05) in the sensitized group. There was no statistically difference in IFN-γ expression between the control group and the sensitized group. Imaging analysis showed that L-NAME could inhibit the expression of IL-4 mRNA (P < 0.05) and increase the expression of IFN-γ mRNA (P < 0.05), while L-Arg could increase the expression of IL-4 mRNA in inflammatory cells (P < 0.05). It was indicated that a suitable levels of intrinsic NO can influence the expression of IL-4 mRNA of Th2 lymphocytes and the expression of IFN-γ mRNA of Thl lymphocytes and in turn, promote the development of asthmatic airway inflammation.     

彩色多普勒超声在老年脑梗死病中的临床应用

应用ＨＤＩ型超９彩色声像仪,观察４１例老年脑梗死患者和４８例无脑梗死老年人（对照组）两侧颈总动脉内膜－中层厚度、斑块情况,两侧颈动脉和椎动脉颅外段内径、血流动力学改变。结果发现：（１）脑梗死组颈总动脉主干与分叉处内膜－中层厚度较对照组明显增厚,发现粥样硬化斑块３２例,占７８．０％;（２）脑梗死组颈总动脉、颈内动脉内径明显增宽;脑梗死组颈动脉和椎动脉颅外段舒张期末流速值、最高流速平均值较对照组明显降低;反映外周阻力的搏动指数、阻力指数,脑梗死组明显高于对照组。结果表明：老年脑梗死与颈动脉、椎动脉粥样硬化有关;颈动脉软斑块是可能发生潜在老年脑梗死的原因之一。     

HPLC-ELSD法测定湖北麦冬中主要皂苷的含量

采用蒸发光散射检测器（ＥＬＳＤ）测定了湖北麦冬中山麦冬皂苷Ｂ的含量,结果表明,ＥＬＳＤ是皂苷类化合物较为适宜的检测器。经对不同采收期样品的含量考察,认为湖北麦冬的最佳采收期与传统采收期（清明）相一致。     

通脉活血灵胶囊对实验性高脂血症家兔血脂及动脉粥样硬化的影响

观察通脉活血灵胶囊对实验性高脂血症家兔血脂调节变化和动脉粥样经形成的影响。实验结果表明,高脂饲料喂养家兔可导致高脂血症,并可诱发动脉弱样硬化。     

Effect of xiongshao capsule on vascular remodeling in porcine coronary balloon injury model

Objective: To study the effect of Xiongshao capsule (XSC) on vascular remodeling in porcine coronary balloon injury model.Methods: Coronary artery restenosis model was established by oversized balloon injury at mid-region of the left anterior descending coronary artery. They were divided into 5 groups, untreated or treated with probucol, Xueguantong, low and high dose of XSC respectively, and compared. The effect of XSC on late lumen loss resulted from vascular remodeling was evaluated by quantitative histological method with combining histopathological analysis and coronary angiographie examination.Results: The (59 ± 20)% of late lumen loss was caused by vascular remodeling and (41 ± 20)% caused by intimai hyperplasia. Compared with the control group, all the treatment could significantly reduce the late lumen loss after balloon injury (P<0.05 orP < 0.01 ), both low and high dose of XSC could significantly reduce the late lumen loss caused by remodeling (P<0.05 and P<0.01 respectively).Conclusion: Vascular remodeling plays an important role in late lumen stenosis formation in coronary artery after balloon injury. XSC could significantly inhibit the pathological vascular remodeling, and thus reduce the late lumen loss and prevent the restenosis of the injured coronary artery. Part of a National Ninth-Five Planning Project (No. 96-9060601)     

升丹制剂对小鼠机械性创面微循环影响的实验研究

目的 通过不同浓度的升压制剂对创面微循环影响来控制其对创面愈合的作用机制。方法 应用彩色病理图文分析系统,分析创面微血管增生数、扩张度及微血栓数。结果 在造模后３天、７天,实验且数值均显著高于对照组。结论 升丹制课题可以和改善创面微循环,减少微血栓,增加创面营养和血供,有利创面愈合。     

Effect of puerarin on fibrinolytic activity and lipid peroxide in patients with coronary heart disease

Effect of Puerarin on Fibrinolytic Activity and Lipid Peroxide in Patients with Coronary Heart Disease@陈江斌 @许家俐 @李建军 @黄从新 @唐其柱 @王晋明 @李庚山     

慢性肾功能衰竭患者畸变产物耳声发射分析

测定２１例（４２耳）慢性肾功能衰竭（ＣＲＦ）患者的畸变产物耳声发射（ＤＰＯＡＥ）。结果表明：ＣＲＦ患者的耳聋 为耳蜗性聋,表现为高频听力损失,ＤＰＯＡＥ检测可客观、快速地反映耳蜗的病变。且ＤＰＯＡＥ具有频率特异性,有助于对该病患者听力障碍的早期诊断。