复杂高陡构造零偏VSP空变倾角时差校正及其处理技术

英买9井曾在白垩系巴西改组获得高产, 但该井周边部署的井油气显示并不理想。在储层和盖层均发育良好的英买9井区内, 断层对英买9井区内的油气富集具有十分重要的影响。为了研究英买9井区断层对油气聚集的控制作用, 利用英买9井区现有资料, 对泥岩涂抹因子进行了计算, 认为F6断层封闭性最好, F1断层其次。通过计算泥岩断层泥比确定有利断层的封烃高度, 再结合相邻区块已开发井位的烃柱高度, 优化计算英买9井区有利断层的封烃高度, 其中F6断层封烃高度可达19.09m, F1断层封烃高度为14.13m。研究结果对该区下一步井位部署具有一定的指导作用。     

基于视觉-前庭感知一致性的运动模拟可信度评价方法

目的提出以运动感知一致性作为运动模拟的可信度评价标准。方法以客观运动模拟测试(objective motion cueing test,OMCT)为基础,引入了视觉-前庭感知一致性理论,并以人的运动感知一致区为期望边界,从而修正运动模拟可信度评价函数。结果相比Advani-Hosman评价标准,本方法可获得更大的幅值可信度与相位可信度区域,扩大了运动模拟的边界。结论运动感知一致性更适合作为飞行训练运动模拟的可信度评价指标。     

利用PACS实施口腔内科根管治疗质量监控的初步研究

目的 探讨标准化方法监控根管治疗质量的应用效果和存在的问题.方法 5名评价者,采用随机、单盲、对照的方法,对存储于PACS中的根管治疗病例进行评价,使用社会科学统计程序(SPSS ver16.9)分析比较其评价结果.结果 随机抽取病例156例,根据根管治疗中的3个阶段4个方面分别给予评价.对于诊断片和定位片,5名评价者的评价结论无统计学差异；对于根管充填位置和密合程度的评价,存在统计学差异.结论 PACS可以作为临床质量监控的手段；管理者在使用PACS监控根管治疗质量时,应当首先进行标准化培训.     

Serum Concentrations of Antibodies against Outer Membrane Protein P6, Protein D,and T- and B-Cell Combined Antigenic Epitopes of Nontypeable Haemophilus influenzae in Children and Adults of Different Ages

Nontypeable Haemophilus influenzae (NTHi) is one of the most common etiologies of acute otitis media, rhinosinusitis, and pneumonia. Outer membrane proteins (OMPs) are the main focus in new vaccine development against NTHi, as the H. influenzae type b (Hib) vaccine does not cover noncapsulated NTHi. The OMPs P6 and protein D are the most promising candidate antigens for an NTHi vaccine, and low antibody levels against them in serum may be correlated with infection caused by NTHi. In the current study, we measured the antibody titers against P6, protein D, and their T- and B-cell combined peptide epitopes in healthy individuals of different ages. We found that children <1 month old had the lowest antibody levels against NTHi P6, protein D, and their T- and B-cell combined antigenic epitopes. Antibody titers increased at ages 1 to 6 months, peaked at 7 months to 3 years, and remained high at 4 to 6 years. The antibody titers started to decrease after 6 years and were the lowest in the 21- to 30-year group. The geometric mean titers (GMTs) of T- and B-cell combined antigenic epitopes in P6 and protein D were positively correlated with those of the protein antigens. Among 12 peptides tested, P6-61, P6-123, and protein D-167 epitopes were better recognized than others in human serum. These findings might contribute to the development of an effective serotype-independent vaccine for H. influenzae.     

基于中华优秀传统文化背景下医学院校公共艺术教育创新路径研究

中华优秀传统文化在新时代发展形势下不断创新，同时坚守中华文化立场，坚固文化自信，成为全社会文化素质发展的主旋律。传承中华优秀传统文化是整个社会的文化议题，更是集历史、政治、艺术、文化等学科为一体的教育素材。研究践行中华传统文化传承与教育的时代主题，探究医学类院校的公共艺术教育和发展现状，分析医学公共教育的方法及特性，着重探讨了中华传统文化在医学院校公共艺术教育中的发展和创新，探索人才素质培养路径，鼓励医学人才承担起传承中华传统文化的重任和使命。     

济南市2014—2018年猩红热流行特征及时空聚集性分析

目的 研究济南市猩红热的流行特征,并对时空聚集性进行分析,为猩红热的防控工作提供依据。方法 从国家疾病监测信息报告管理系统中获取济南市2014—2018年猩红热疫情资料,采用描述性流行病学方法及时空重排扫描统计方法分析猩红热病例的流行病学和时空分布特征。结果 2014—2018年济南市累计报告猩红热7 297例,年均发病率20.46/10万。全年出现冬季和春季2个发病高峰。病例主要集中在1~9岁儿童,幼托儿童、学生及散居儿童发病数占总病例数的99.70%,男女性别比1.70∶1。市中区、历城区、槐荫区、天桥区、历下区是主要高发地区,占病例总数的83.50%。按年进行时空聚集性分析,每年均探测到3个时空聚集区,具有显著时空聚集性。结论 2014—2018年济南市猩红热处于上升趋势,学校和托幼机构是发病的高危场所,应根据时空分布及流行特征,制定相应的防控措施,控制猩红热的发生和扩散。     

Cyanidin-3-glucoside protects against high glucose-induced injury in human nucleus pulposus cells by regulating the Nrf2/HO-1 signaling

Cyanidin-3-glucoside (C3G) is a well-known natural anthocyanin with antioxidant and anti-inflammatory properties. In this study, we explored the role and action mechanism of C3G in high glucose (HG)-induced damage of human nucleus pulposus cells (HNPCs). Cell viability was assessed by CCK-8 assay. TUNEL assay was performed for detecting apoptotic rate. Western blot was performed to determine the expression levels of cl-caspase-3, caspase-3, Bax, Bim, collagen II, aggrecan, MMP-3, MMP-13, and ADAMTS5. Reactive oxygen species (ROS) generation was analyzed using DCFH-DA staining. The Nrf2 was knocked down or overexpressed in HNPCs through transfection with si-Nrf2 or pcDNA3.0-Nrf2. C3G treatment (12.5, 25, and 50 μM) improved cell viability of HNPCs under HG condition. HG-induced cell apoptosis of HNPCs was attenuated by C3G with decreased apoptotic rate and relative levels of cl-caspase-3/caspase-3, Bax, and Bim. C3G treatment caused significant increase in expression levels of collagen II and aggrecan and decrease in the relative levels of MMP-3, MMP-13, and ADAMTS5. After treatment with C3G, ROS generation in HNPCs was markedly reduced. Treatment with N-acetylcysteine (NAC) reversed HG-induced cell apoptosis and extracellular matrix (ECM) degradation. C3G treatment induced the expression of Nrf2 and HO-1 in HG-induced HNPCs. Moreover, knockdown of Nrf2 reversed the inhibitory effect of C3G on ROS production. Summarily, C3G exerted a protective effect on ROS-mediated cellular damage in HNPCs under HG condition, which was attributed to the induction of the Nrf2/HO-1 signaling pathway.