解毒消肿散在外科中的临床应用

笔者从事临床医疗工作20余年,自拟解毒消肿散治疗因阳热毒邪蕴蒸肌肤所致的多种外科疾患,屡获捷效,现报道如下。方药组成与使用方法蒲公英30g,紫花地丁30g,玄明粉50g,冰片6g,共研细末调和均匀,贮瓶密封备用。使用时,视肿疡面积大小,取适量药粉,用食醋调成糊状,摊敷在病变部位,厚约0.5~0.8cm,用塑料薄膜覆盖,外用胶布固定。药物干燥时,可再用食醋浸湿。每日换药2~3次。本方具有清热解毒、散瘀消肿、消炎止痛的作用。主治痈、疽、疔、疖、乳痈、痄腮、毒虫咬伤、痔瘘、肛裂、无名肿毒等证,凡红肿热痛属阳证、热证、实证者均可应用,阴证、寒证…     

磁共振成像在乳腺癌中的应用：究竟是进了一步还是退了两步？

目前，人们正对乳腺磁共振成像（magnetic resonance imaging，MRI）的应用进行研究，表现在两个不同方面：一是将MRI列为乳腺癌高危妇女（例如BRCA1和BRCA2基因发生突变者）的筛查方法；二是对乳腺癌确诊或可疑患者行乳腺X线的同时辅以MRI以决定是否选用局部疗法。这两种用途的依据迥然不同。有预置性突变（predisposition mutations）的妇女乳腺癌发病年龄通常较低，此时由于乳腺组织较为致密，因而乳腺X线筛查的敏感性有所减低。     

腰椎间盘突出症人工椎间盘置换手术及效果

目的 :观察采用SBCharit啨人工椎间盘置换手术治疗腰椎间盘突出症的临床效果?椒?:左下腹部腹直肌旁切口 ,切断腹直肌鞘及后层 ,钝性分离腹主动脉和静脉 ,并游离到右边用棉垫加以保护。然后作一“H”型切口切开纤维环 ,用刮匙和咬骨钳清除椎间盘组织特别是髓核。将SBCharit啨人工椎间盘植入?峁?:8例中有 7例 (87.5 % )的临床效果为相当好 ,1个病人 (12 .5 % )为一般 ,有背疼或腿部症状需偶尔服药。椎体活动范围平均为 9°。没有发现有假体松动、下沉入椎体。结论 :若适应证选择得当 ,将获得满意效果。     

变形链球菌表面蛋白和葡糖基转移酶基因疫苗对唾液变形链球菌和牙菌斑的影响

目的　了解变形链球菌表面蛋白和葡糖基转移酶基因疫苗单独及联合免疫对定菌鼠唾液变链菌和牙面菌斑的影响。方法　 2 8d龄 Wistar大鼠 3 6只 ,随机分为 pc DNA3 - pac组、pc DNA3 - gtf B组、pc DNA3 - pac联合pc DNA 3 - gtf B组、变形链球菌灭活全菌组、pc DNA3空载体组和 PBS液组 ,进行三次双侧颌下腺腺周注射免疫 ,建立定菌鼠模型 ,作诱龋实验 3个月。唾液变链菌计数和菌斑计分。结果　唾液变链菌菌落计数和牙面菌斑计分在 pc D-NA3与 PBS组最高 ,其次为单基因疫苗免疫组 ,联合基因疫苗和灭活全菌细胞免疫组最低 ,各组间有显著性差异 ( P<0 .0 5 )。结论　 pc DNA3 - gtf B和 pc DNA3 - pac具有明显的免疫抑菌作用 ,联合基因疫苗免疫优于单基因疫苗     

流行性出血热患者骨髓细胞超微结构的研究

8例流行性出血热患者骨髓细胞的超微结构研究结果发现骨髓细胞出现变性、空泡、粗面内质网及高尔基体扩张。并在胞浆中发现颗粒-丝状病毒包涵体及直径为100nm的病毒颗粒。同时胶体金免疫电镜发现骨髓细胞EHF抗原阳性,说明骨髓细胞是其繁殖、复制的场所。     

An animal model of chronic tympanic membrane perforation.

Previous investigations into the healing and reconstruction of tympanic membrane (TM) perforations have involved animal models with acute TM perforations. A problem with the acute TM perforation model is that most acute TM perforations will heal spontaneously, both in animals and human beings. A second inadequacy of acute perforation models is that they are not analogous to the salient problem in human beings: long-standing TM perforation. The ideal animal model must have a TM perforation that is permanent, well-epithelialized, and free from infection. The perforation must also be subtotal to preserve a rim of membrane for experimental manipulations. In the chinchilla, we have identified a hardy animal with a short, wide ear canal and relatively large tympanic membranes. Thermal myringectomy, followed by medial infolding of TM microflaps, has resulted in permanent, subtotal chronic TM perforations in the chinchilla animal model. Of the 19 chinchillas (38 TMs) perforated, chronic subtotal perforations were created in 32 ears, 6 to 8 weeks after the initial procedure (84% success). Persistent infection or TM regeneration despite reperforation was recorded in 6 ears (16%) failure). This model is currently being used to assess various biomembrane scaffolds impregnated with growth-promoting substances in the regeneration of a physiologically sound TM, initially in our animal model and then in human beings. We envision the development of a biomembrane disc impregnated with biorecombinant growth factors that may provide a simple office technique for the repair of chronic, non-infected TM perforations.     

Efficacy of lumiracoxib in relieving pain associated with knee osteoarthritis: a 6‐week,randomized, double‐blind,parallel‐group study

Aim: The aim of the current study was to assess the efficacy, safety, and tolerability of lumiracoxib 200 mg once daily (o.d.) in relieving osteoarthritis (OA) knee pain in patients in China, Taiwan, and South Korea. Methods: Patients of either sex (aged ≥ 18 years) with symptomatic, primary OA of the knee for ≥ 3 months were eligible for inclusion if they had OA pain intensity of ≥ 40 mm (100 mm visual analogue scale [VAS]) in the target knee joint during the previous 24 h. Patients were required to undergo regular non‐steroidal anti‐inflammatory drug therapy for ≥ 6 weeks. After 3–7 days of screening, patients were randomized (1 : 1) to receive either lumiracoxib 200 mg o.d. or celecoxib 200 mg o.d. The primary efficacy comparison between the study groups was overall OA pain intensity (VAS) in the target knee after 6 weeks of treatment. Results: The mean overall OA pain intensity (VAS) in the target knee after 6 weeks decreased from 60.6 mm to 35.7 mm and 60.5 mm to 36.1 mm in the lumiracoxib and celecoxib groups, respectively. Both study groups showed similar results in terms of improvement in both patient's and physician's global assessment of disease activity and functional health status. The percentage of adverse events (AEs) in the lumiracoxib and celecoxib groups (40.3% and 37.9%, respectively) was similar, as was the proportion of treatment‐related AEs (21.0% and 18.2%, respectively). Conclusions: Lumiracoxib 200 mg o.d. provided effective and well‐tolerated pain relief similar to that achieved with celecoxib 200 mg o.d. in knee OA patients.     

耳尖放血治疗痄腮98例

痄腮即流行性腮腺炎,是由风热疫毒上攻头面所致,为常见的急性传染病.笔者根据先师郑卓人先生所传授之经验,多年来运用耳尖放血疗法治疗本病98例,效果明显.现介绍如下.     

辐照氟银猪皮的实验研究

报道辐照氟银猪皮的制备、实验检测（弹性、创面粘附力和透水性测定，含银量测定）组织学检查细菌检测及抑菌试验研究，结果表明：辐照氟银猪皮除延伸度低于未辐照猪皮外，其撕裂强度、创面粘合力和透水性均与未辐照猪皮相似。组织学检查示：辐照氟银猪皮组织结构完整，表皮细胞部分空泡形成。组织细菌检测证明其无菌生长，达到无菌要求。抑菌试验证明对金黄色葡萄球菌、绿脓杆菌、大肠杆菌、变形杆菌、克雷伯氏菌均有极强的抑菌作用     

开颅术后张力性气颅

报告１９８８年１２月～１９９２年１２月开颅术后张力性气颅５例，男４，女１．５例中３例治愈，２例死亡。开颅术后张力性气颅产生的主要原因是颅内占位性病变切除后，脑脊液丢失，使颅内压降低，甚至呈负压状态，外界的气体从切口进入颅内的腔隙，ＣＴ扫描或颅骨Ｘ线平片可以确定诊断，钻孔置管排气是活疗张力性气颅的有效方法，作者探讨了预防此种并发症发生的措施。