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101.
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Evelina Chapman Ludovic Reveiz Amy Chambliss Stephanie Sangalang Xavier Bonfill 《Journal of clinical epidemiology》2013,66(1):105-112
ObjectivesTo use an “evidence-mapping” approach to assess the usefulness of Cochrane reviews in identifying research gaps in the maternal health.Study Design and SettingThe article describes the general mapping, prioritizing, reconciling, and updating approach: (1) identifying gaps in the maternal health research using published systematic reviews and formulating research questions, (2) prioritizing questions using Delphi method, (3) reconciling identified research priorities with the existing literature (i.e., searching of ongoing trials in trials registries), (4) updating the process. A comprehensive search of Cochrane systematic reviews published or updated from January 2006 to March 2011 was performed. We evaluated the “Implications for Research” section to identify gaps in the research.ResultsOur search strategy identified 695 references; 178 systematic reviews identifying at least one research gap were used. We formulated 319 research questions, which were classified into 11 different categories based on the direct and indirect causes of maternal mortality: postpartum hemorrhage, abortion, hypertensive disorders, infection/sepsis, caesarean section, diabetes, pregnancy prevention, preterm labor, other direct causes, indirect causes, and health policies and systems. Most research questions concerned the effectiveness of clinical interventions, including drugs (42.6%), nonpharmacologic interventions (16.3%), and health system (14.7%).ConclusionIt is possible to identify gaps in the maternal health research by using this approach. 相似文献
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David E. Barroso Terezinha M.P.P. Casti?eiras Fernanda S. Freitas Jane W. Marsh Mary G. Krauland Mary M. Tulenko érica L. Fonseca Ana C.P. Vicente Maria C. Rebelo Elaine O. Cerqueira Adriano C. Xavier Ana P.C.M. Cardozo Simone E.M. da Silva Lee H. Harrison 《Emerging infectious diseases》2013,19(11):1847-1850
During 2003–2012, 8 clusters of meningococcal disease were identified in Rio de Janeiro State, Brazil, all caused by serogroup C Neisseria meningitidis. The isolates were assigned to 3 clonal complexes (cc): cc11, cc32, and cc103. These hyperinvasive disease lineages were associated with endemic disease, outbreaks, and high case-fatality rates. 相似文献
106.
T.C.A. Ferrari M.A.P. Xavier P.V.T. Vidigal N.S. Amaral P.A. Diniz A.P. Resende D.M. Miranda A.C. Faria A.S. Lima L.C. Faria 《Brazilian journal of medical and biological research》2014,47(11):990-994
Estimates of occult hepatitis B virus (HBV) infection prevalence varies among
different studies depending on the prevalence of HBV infection in the study
population and on the sensitivity of the assay used to detect HBV DNA. We
investigated the prevalence of occult HBV infection in cirrhotic patients undergoing
liver transplantation in a Brazilian referral center. Frozen liver samples from 68
adults were analyzed using a nested polymerase chain reaction assay for HBV DNA. The
specificity of the amplified HBV sequences was confirmed by direct sequencing of the
amplicons. The patient population comprised 49 (72.1%) males and 19 (27.9%) females
with a median age of 53 years (range=18-67 years). Occult HBV infection was diagnosed
in three (4.4%) patients. The etiologies of the underlying chronic liver disease in
these cases were alcohol abuse, HBV infection, and cryptogenic cirrhosis. Two of the
patients with cryptic HBV infection also presented hepatocellular carcinoma. Markers
of previous HBV infection were available in two patients with occult HBV infection
and were negative in both. In conclusion, using a sensitive nested polymerase chain
reaction assay to detect HBV DNA in frozen liver tissue, we found a low prevalence of
occult HBV infection in cirrhotic patients undergoing liver transplant, probably due
to the low prevalence of HBV infection in our population. 相似文献
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108.
Amitava Mitra Sandra Suarez-Sharp Xavier J.H. Pepin Talia Flanagan Yang Zhao Evangelos Kotzagiorgis Neil Parrott Satish Sharan Christophe Tistaert Tycho Heimbach Banu Zolnik Erik Sjögren Fang Wu Om Anand Shefali Kakar Min Li Shereeni Veerasingham Shinichi Kijima Andrew Babiskin 《Journal of pharmaceutical sciences》2021,110(2):594-609
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110.