全文获取类型
收费全文 | 1638篇 |
免费 | 157篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 61篇 |
妇产科学 | 56篇 |
基础医学 | 214篇 |
口腔科学 | 106篇 |
临床医学 | 188篇 |
内科学 | 368篇 |
皮肤病学 | 24篇 |
神经病学 | 142篇 |
特种医学 | 49篇 |
外科学 | 181篇 |
综合类 | 16篇 |
一般理论 | 1篇 |
预防医学 | 157篇 |
眼科学 | 13篇 |
药学 | 134篇 |
肿瘤学 | 74篇 |
出版年
2021年 | 17篇 |
2019年 | 29篇 |
2018年 | 26篇 |
2017年 | 11篇 |
2016年 | 20篇 |
2015年 | 24篇 |
2014年 | 20篇 |
2013年 | 37篇 |
2012年 | 75篇 |
2011年 | 89篇 |
2010年 | 49篇 |
2009年 | 41篇 |
2008年 | 70篇 |
2007年 | 100篇 |
2006年 | 81篇 |
2005年 | 71篇 |
2004年 | 80篇 |
2003年 | 83篇 |
2002年 | 68篇 |
2001年 | 71篇 |
2000年 | 59篇 |
1999年 | 59篇 |
1998年 | 25篇 |
1997年 | 13篇 |
1996年 | 21篇 |
1995年 | 22篇 |
1994年 | 14篇 |
1993年 | 17篇 |
1992年 | 39篇 |
1991年 | 32篇 |
1990年 | 31篇 |
1989年 | 23篇 |
1988年 | 24篇 |
1987年 | 34篇 |
1986年 | 20篇 |
1985年 | 29篇 |
1984年 | 20篇 |
1983年 | 12篇 |
1982年 | 12篇 |
1979年 | 10篇 |
1978年 | 10篇 |
1977年 | 9篇 |
1976年 | 12篇 |
1974年 | 15篇 |
1973年 | 10篇 |
1971年 | 17篇 |
1970年 | 11篇 |
1968年 | 11篇 |
1967年 | 14篇 |
1966年 | 11篇 |
排序方式: 共有1796条查询结果,搜索用时 15 毫秒
51.
52.
Cook PC Jones LH Jenkins SJ Wynn TA Allen JE MacDonald AS 《Proceedings of the National Academy of Sciences of the United States of America》2012,109(25):9977-9982
Interleukin-4 is a cytokine widely known for its role in CD4(+) T cell polarization and its ability to alternatively activate macrophage populations. In contrast, the impact of IL-4 on the activation and function of dendritic cells (DCs) is poorly understood. We report here that DCs respond to IL-4 both in vitro and in vivo by expression of multiple alternative activation markers with a different expression pattern to that of macrophages. We further demonstrate a central role for DC IL-4Rα expression in the optimal induction of IFNγ responses in vivo in both Th1 and Th2 settings, through a feedback loop in which IL-4 promotes DC secretion of IL-12. Finally, we reveal a central role for RELMα during T-cell priming, establishing that its expression by DCs is critical for optimal IL-10 and IL-13 promotion in vitro and in vivo. Together, these data highlight the significant impact that IL-4 and RELMα can have on DC activation and function in the context of either bacterial or helminth pathogens. 相似文献
53.
Samarasinghe S Steward C Hiwarkar P Saif MA Hough R Webb D Norton A Lawson S Qureshi A Connor P Carey P Skinner R Vora A Pelidis M Gibson B Stewart G Keogh S Goulden N Bonney D Stubbs M Amrolia P Rao K Meyer S Wynn R Veys P 《British journal of haematology》2012,157(3):339-346
We retrospectively analysed the outcome of consecutive children with idiopathic severe aplastic anaemia in the United Kingdom who received immunosuppressive therapy (IST) or matched unrelated donor (MUD) haematopoietic stem cell transplantation (HSCT). The 6-month cumulative response rate following rabbit antithymocyte globulin (ATG)/ciclosporin (IST) was 32·5% (95% CI 19·3-46·6) (n = 43). The 5-year estimated failure-free survival (FFS) following IST was 13·3% (95% confidence interval [CI] 4·0-27·8). In contrast, in 44 successive children who received a 10-antigen (HLA-A, -B, -C, -DRB1, -DQB1) MUD HSCT there was an excellent estimated 5-year FFS of 95·01% (95% CI 81·38-98·74). Forty of these children had failed IST previously. HSCT conditioning was a fludarabine, cyclophosphamide and alemtuzumab (FCC) regimen and did not include radiotherapy. There were no cases of graft failure. Median donor chimerism was 100% (range 88-100%). A conditioning regimen, such as FCC that avoids total body irradiation is ideally suited in children. Our data suggest that MUD HSCT following IST failure offers an excellent outcome and furthermore, if a suitable MUD can be found quickly, MUD HSCT may be a reasonable alternative to IST. 相似文献
54.
Czuczman MS Hess G Gadeberg OV Pedersen LM Goldstein N Gupta I Jewell RC Lin TS Lisby S Strange C Windfeld K Viardot A; Study Investigators 《British journal of haematology》2012,157(4):438-445
An international, Phase II trial was conducted to assess two doses of ofatumumab, a human CD20 monoclonal antibody, combined with cyclophosphamide (750 mg/m2), doxorubicin (50 mg/m2), prednisone (100 mg days 3–7) and vincristine (1·4 mg/m2) (O‐CHOP), as frontline treatment for follicular lymphoma (FL). 59 patients with previously untreated FL were randomized to ofatumumab 500 mg (n = 29) or 1000 mg (n = 30) day 1, with CHOP on day 3 every 3 weeks for six cycles. Median duration of FL was 0·1 years for both dose groups; 34% and 38% of patients had high‐risk Follicular Lymphoma International Prognostic Index (FLIPI) scores in the 500‐ and 1000‐mg dose groups, respectively. Overall response rate was 90% for the 500‐mg group and 100% for the 1000‐mg group. 62% of patients achieved complete response (CR)/unconfirmed CR (CRu). 76% of patients with FLIPI score 3–5 attained CR/CRu. Longer follow‐up time is needed for analysis of survival end points. The most common Common Terminology Criteria grade 3–4 investigator‐reported adverse events were leucopenia (29%) and neutropenia (22%). No deaths have been reported. O‐CHOP was safe and efficacious in patients with previously untreated FL, including high‐risk FLIPI groups. This trial was registered at www.clinicaltrials.gov (NCT00494780). 相似文献
55.
BackgroundThe supplementary motor area (SMA) has been implicated in many aspects of movement preparation and execution. In addition to motor roles, the SMA is responsive to somesthetic stimuli though it is unclear exactly what role the SMA plays in a somatosensory network.Objective/HypothesisIt is the purpose of this study to assess how continuous theta burst stimulation (cTBS) of the SMA affects both somatosensory (SEPs) and motor evoked potentials (MEPs) and if cTBS leads to alterations in tactile perception thresholds of the index fingertip.MethodsIn experiment 1, cTBS was delivered over scalp sites FCZ (SMA stimulation) (n = 10) and CZ (control stimulation) (n = 10) in separate groups for 40 s (600 pulses) at 90% of participants' resting motor threshold. For both groups, median nerve SEPs were elicited from the right wrist at rest via electrical stimulation (0.5 ms pulse) before and at 10 min intervals post-cTBS out to 30 min (t = pre, 10, 20, and 30 min). Subjects' perceptual thresholds were assessed at similar time intervals as the SEP data using a biothesiometer (120 Hz vibration). In experiment 2 (n = 10) the effect of cTBS to SMA upon single and paired-pulse MEP amplitudes from the right first dorsal interosseous (FDI) was assessed.ResultscTBS to scalp site FCZ (SMA stimulation) reduced the frontal N30 SEP and increased tactile perceptual thresholds 30 min post-stimulation. However, parietal SEPs and MEP amplitudes from both single and paired-pulse stimulation were unaffected at all time points post-stimulation. cTBS to stimulation site CZ (control) did not result in any physiological or behavioral changes.Conclusion(s)These data demonstrate cTBS to the SMA reduces the amplitude of the N30 coincident with an increase in vibration sensation threshold but does not affect primary somatosensory or motor cortex excitability. The SMA may play a significant role in a somatosensory tactile attention network. 相似文献
56.
Julia Wynn Gudrun Aspelund Annette Zygmunt Charles J.H. Stolar George Mychaliska Jennifer Butcher Foong-Yen Lim Teresa Gratton Douglas Potoka Kate Brennan Ken Azarow Barbara Jackson Howard Needelman Timothy Crombleholme Yuan Zhang Jimmy Duong Marc S. Arkovitz Wendy K. Chung Christiana Farkouh 《Journal of pediatric surgery》2013
Purpose
To determine developmental outcomes and associated factors in patients with congenital diaphragmatic hernia (CDH) at 2 years of age.Methods
This is a multicenter prospective study of a CDH birth cohort. Clinical and socioeconomic data were collected. Bayley Scales of Infant Development (BSID-III) and Vineland Adaptive Behavior Scales (VABS-II) were performed at 2 years of age.Results
BSID-III and VABS-II assessments were completed on 48 and 49 children, respectively. The BSID-III mean cognitive, language, and motor scores were significantly below the norm mean with average scores of 93 ± 15, 95 ± 16, and 95 ± 11. Ten percent (5/47) scored more than 2 standard deviations below the norm on one or more domains. VABS-II scores were similar to BSID-III scores with mean communication, daily living skills, social, motor, adaptive behavior scores of 97 ± 14, 94 ± 16, 93 ± 13, 97 ± 10, and 94 ± 14. For the BSID-III, supplemental oxygen at 28 days, a prenatal diagnosis, need for extracorporeal membrane oxygenation (ECMO) and exclusive tube feeds at time of discharge were associated with lower scores. At 2 years of age, history of hospital readmission and need for tube feeds were associated with lower scores. Lower socioeconomic status correlated with lower developmental scores when adjusted for significant health factors.Conclusion
CDH patients on average have lower developmental scores at 2 years of age compared to the norm. A need for ECMO, oxygen at 28 days of life, ongoing health issues and lower socioeconomic status are factors associated with developmental delays. 相似文献57.
58.
59.
60.