童年期心理虐待和忽视、述情障碍对大学生无聊倾向的影响

目的探讨童年期心理虐待和忽视、述情障碍对大学生无聊倾向的影响及其关系。方法采用大学生无聊倾向问卷(boredom proneness scale for college students,BPS)、儿童心理虐待和忽视量表(child psychological abuse and neglect scale,CPANS)、多伦多述情障碍量表(the Toronto alexithymia scale,TAS-20)对1557名大学生进行调查,采用SPSS 22.0进行描述性统计、相关分析和回归分析。结果童年心理虐待[(26.540±8.985)分]、忽视[(32.665±10.651)分]、述情障碍的识别情感维度[(19.359±4.835)分]、描述情感维度[(14.173±3.001)分],外向思维维度[(20.383±3.429)分]与无聊倾向总分[(101.109±19.735)分]、外部刺激维度[(66.022±21.079)分]存在正相关(r=0.160~0.559,均P<0.01),而与内部刺激维度[(35.132±8.207)分]存在负相关(r=-0.302~-0.104,均P<0.01)。分层回归分析显示,在控制性别和年龄的影响后,心理虐待与忽视是无聊倾向、内部刺激和外部刺激的影响因素,分别可解释总变异的14.3%,5.1%和18.2%(△F=130.561、41.968、172.711,均P<0.01)。述情障碍的识别情绪、描述情绪和外向思维是无聊倾向、内部刺激和外部刺激的影响因素,分别可解释总变异的17.5%,9.9%和25.5%(△F=134.274、60.696、234.383,P<0.01)。结论童年心理虐待和忽视、述情障碍对大学生无聊倾向存在显著影响,主要体现在对无聊倾向的外部刺激的影响上,其中述情障碍影响最大、解释力最高。     

新癀片联合盐酸米诺环素软膏治疗牙周炎效果评价

目的:探讨新癀片联合盐酸米诺环素软膏治疗牙周炎的临床疗效及对炎症因子水平的影响.方法:选择牙周炎患者150例为研究对象,根据入院时间不同将其分为对照组(75例)与观察组(75例),对照组采用盐酸米诺环素软膏治疗,观察组联合新癀片治疗,疗程均为4周;观察2组临床疗效、治疗前后龈沟液炎症因子水平、不良反应情况.结果:观察组治疗总有效率(94.66％)高于对照组(82.67％),治疗后TNF-α[(3.52±0.40)vs(4.76±0.76)ng·mL-1]、IL-6[(1.43±0.27)vs(1.96±0.35)pg·mL-1]、CRP[(13.42±2.58)vs(17.65±3.16)mg·mL-1]低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率(6.66％)高于对照组(5.34％),但差异无统计学意义(P>0.05).结论:新癀片联合盐酸米诺环素软膏治疗牙周炎可降低患者炎症因子水平,提高临床疗效,安全性高.     

A movable microelectrode array for chronic basal ganglia single-unit electrocorticogram co-recording in freely behaving rats

The basal ganglia–cortical circuits are important for information process to brain function. However, chronic recording of single-unit activities in the basal ganglia nucleus has not yet been well established. We present a movable bundled microwire array for chronic subthalamic nucleus (STN) single-unit electrocorticogram co-recording. The electrode assembly contains a screw-advanced microdrive and a microwire array. The array consists of a steel guide tube, five recording wires and one referenced wire which form the shape of a guiding hand, and one screw electrode for cortico-recording. The electrode can acquire stable cortex oscillation-driven STN firing units in rats under different behaving conditions for 8 weeks. We achieved satisfying signal-to-noise ratio, portions of cells retaining viability, and spike waveform similarities across the recording sections. Using this method, we investigated neural correlations of the basal ganglia–cortical circuits in different behaving conditions. This method will become a powerful tool for multi-region recording to study normal statements or movement disorders.     

Spinal root avulsion: an excellent model for studying motoneuron degeneration and regeneration after severe axonal injury简

<正>Spinal root avulsion is an excellent model for studying the response of motoneurons to severe injury to their axons(Koliatsos et al.,1994).In this model(‘Avulsion Model’),spinal roots are torn off from spinal cord without removing the vertebra at     

Microsatellite primer development for the king ratsnakes Elaphe carinata (Colubridae)

The king ratsnakes (Elaphe carinata) is widespread in south-eastern China, North Vietnam, and Japan (Ryukyu Islands). The snake is listed as a vulnerable species according to the China Red Data Book of Endangered Animals. To develop effective conservation strategies for the snake, we need a better understanding of gene flow, population structure and evolutionary history of this species by using kinds of molecular markers such as mitochondrial DNA and microsatellite loci. Here, we characterize 12 polymorphic microsatellite loci isolated from E. carinata genomic libraries. One hundred and thirty-one individuals were collected from three geographically distant populations: Ji’an (Jiangxi, N26°59′30″, E114°58′58″), Quanzhou (Guangxi, N25°44′20″, E111°6′48″), Zhijiang (Hunan, N27°20′36″, E109°8′46″). These markers revealed a high degree of genetic diversity (6–20 alleles per locus) and heterozygosity (H _O ranged from 0.326 to 0.894, and H _E ranged from 0.542 to 0.918). No locus exhibited significant deviations from Hardy–Weinberg equilibrium. There was no evidence of linkage disequilibrium among pairs of loci. These microsatellite markers will be useful for the study of gene flow, population structure and evolutionary history of E. carinata.     

Mechanism and Site of Inhibition of AMPA Receptors: Pairing a Thiadiazole with a 2,3-Benzodiazepine Scaffold

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