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排序方式: 共有794条查询结果,搜索用时 31 毫秒
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DR Brewster MJ Manary IS Menzies EV O'Loughlin RL Henry 《Archives of disease in childhood》1997,76(3):236-241
Intestinal permeability can be assessed non-invasively using the lactulose-rhamnose (L-R) test, which is a reliable measure of small intestinal integrity. AIMS: To determine risk factors for abnormal intestinal permeability in kwashiorkor, and to measure changes in L-R ratios with inpatient rehabilitation. DESIGN: A case-control study of 149 kwashiorkor cases and 45 hospital controls. The L-R test was adapted to study kwashiorkor in Malawi, with testing at weekly intervals during nutritional rehabilitation. Urine sugars were measured by thin layer chromatography in London. RESULTS: The initial geometric mean L-R ratios (x100) (with 95% confidence interval) in kwashiorkor were 17.3 (15.0 to 19.8) compared with 7.0 (5.6 to 8.7) for controls. Normal ratios are < 5, so the high ratios in controls indicate tropical enteropathy syndrome. Abnormal permeability in kwashiorkor was associated with death, oliguria, sepsis, diarrhoea, wasting and young age. Diarrhoea and death were associated with both decreased L-rhamnose absorption (diminished absorptive surface area) and increased lactulose permeation (impaired barrier function) whereas nutritional wasting affected only L-rhamnose absorption. Despite, clinical recovery, mean L-R ratios improved little on treatment, with mean weekly ratios of 16.3 (14.0 to 19.0), 13.3 (11.1 to 15.9) and 14.4 (11.0 to 18.8). CONCLUSION: Abnormal intestinal permeability in kwashiorkor correlates with disease severity, and improves only slowly with nutritional rehabilitation. 相似文献
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Interactive suppression of aberrant crypt foci induced by azoxymethane in rat colon by phytic acid and green tea 总被引:1,自引:2,他引:1
Several epidemiological studies point to a strong correlation between
nutrient composition of the diet and cancer of the colon. Phytic acid,
present in grains, has been credited with reducing the risk of cancer of
the colon. A number of reports are available indicating the benefits of
green tea consumption in reducing the risk of stomach, lung and skin
cancer, but little data are available on the effect of green tea in
reducing the risk of colon cancer. Also, there are no studies on the
combined effect of these compounds on colon tumorigenesis. Thus the primary
objective of this investigation was to elucidate the combined effects of
green tea and phytic acid on colonic preneoplastic lesions and the Phase II
enzyme glutathione S-transferase. Fisher 344 male weanling rats were
divided into nine groups of 15 rats each and fed the experimental diet for
13 weeks. Rats received two s.c. injections of azoxymethane in saline at 16
mg/kg body wt at 7 and 8 weeks of age. Rats received three levels (0, 1 and
2%) of phytic acid with three levels (0, 1 and 2%) of green tea within each
phytic acid level in a 3 x 3 factorial experiment. Results indicate that
while green tea had a marginal effect (P < 0.14), phytic acid
significantly reduced the incidence of aberrant crypt foci (P < 0.008).
The interaction between green tea and phytic acid was significant (P <
0.029 for distal and < 0.0168 for entire colon) and positive, pointing
to a synergistic effect of green tea and phytic acid.
相似文献
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F. Worsnop J. Wee J. Natkunarajah Y. Moosa R. Marsden 《Clinical and experimental dermatology》2012,37(8):879-881
Toxic epidermal necrolysis (TEN) is a rare, life‐threatening skin reaction for which there is currently has no standardized treatment, despite its significant mortality. Biological agents such as tumour necrosis factor (TNF)‐α antagonists are emerging as a novel treatment for patients with TEN. We report a 32‐year‐old woman who developed TEN secondary to sulfasalazine, which was treated with infliximab. The infliximab treatment subsequently triggered erosive lichen planus (LP) involving the mouth and vulva. Clinicians should be aware that TNF‐α antagonists can cause LP as a paradoxical complication of treatment. 相似文献
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Reza Saeidi Pour DR MED DENT Otto Zuhr DR MED DENT Markus Hürzeler PROF DR MED DENT Otto Prandtner MDT Caroline Freitas Rafael Daniel Edelhoff PROF DR MED DENT Anja Liebermann DR MED DENT 《Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]》2017,29(2):93-101
30.
Generation of "bastard" molecular ions from van der Waals clusters: Ar(n)(C(2)Cl(4))(m) ions, suspected interlopers in collection of solar neutrinos
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Buelow SJ Worsnop DR Herschbach DR 《Proceedings of the National Academy of Sciences of the United States of America》1981,78(12):7250-7253
Gaseous molecular ions containing argon and perchlorethylene, Arn(C2Cl4)m+ in which n ≥ 1-29 and m ≥ 1-4, are produced by electron bombardment of van der Waals clusters formed by expanding an Ar/C2Cl4 mixture through a supersonic nozzle. Previous attempts to observe such ions in a high-pressure mass spectrometer were not successful, as with many other (“bastard”) ions that similarly lack a stable chemically bound neutral parent molecule. This is probably due to dissociation induced by the large exoergicity from charge transfer between species that differ greatly in ionization potential. Use of van der Waals clusters as parent species avoids entirely the exoergicity problem and thus offers a general method to generate bastard ions. The Ar(C2Cl4)m+ ions have been suspected of interfering with collection of 37Ar+ ions produced by the 37Cl(v,e-)37Ar+ reaction in the solar neutrino observatory. Although, as shown by our results, these ions are stable, they are unlikely to inhibit collection on the long time scale of the solar neutrino experiment. 相似文献