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141.
Bo-Bae Choi Won-Hee Jee Hee-Jung Sunwoo Jae-Hyun Cho Jee-Young Kim Kyung-Ah Chun Suk-Joo Hong Hye Won Chung Mi-Sook Sung Yeon-Soo Lee Yang-Guk Chung 《Clinical imaging》2013,37(3):542-547
PurposeTo evaluate magnetic resonance (MR) imaging for the discrimination between low-grade chondrosarcoma and enchondroma.Materials and methodsMR images of 34 patients who were confirmed with low-grade chondrosarcoma or enchondroma were retrospectively reviewed. After review of medical records, MR findings in 18 patients with low-grade chondrosarcoma and 16 patients with enchondroma were compared. MR images were retrospectively reviewed for the lesion location (central or eccentric; epiphysis, metaphysic, or diaphysis), margin, contour, mineralized matrix, endosteal scalloping, cortical expansion, cortical destruction, soft tissue mass formation, and periosteal reaction. Signal intensity, the patterns of contrast enhancement (unilocular or multilobular), soft tissue mass, and adjacent abnormal bone marrow and soft tissue signal were also reviewed. Statistical analysis was performed with chi-square test.ResultsThe patients with low-grade chondrosarcoma had a significantly higher incidence of MR findings (P< .05): predominantly intermediate signal on T1-weighted images [72% (13/18) in low-grade chondrosarcoma vs. 25% (4/16) in enchondroma], multilocular appearance on contrast-enhanced T1-weighted images [83% (15/18) vs. 44% (7/16)], cortical destruction [33% (6/18) vs. 0% (0/16)], a soft tissue mass [28% (5/18) vs. 0% (0/16)], adjacent bone marrow and soft tissue abnormal signal [22% (4/18) vs. 0% (0/16)], and an involvement of the epiphysis or flat bone [56% (10/18) vs. 19% (3/16)].ConclusionMR imaging shows helpful features for differentiating low-grade chondrosarcoma from enchondroma. 相似文献
142.
Jung Eun Kim Mi-Hye Hwang Ho Won Lee Sang-Woo Lee Jaetae Lee Byeong-Cheol Ahn 《Nuclear medicine and biology》2013,40(8):987-993
PurposeThe purpose of this study was to investigate the anticancer effects of combined RNA interference (RNAi) of the adenine nucleotide translocase-2 (ANT2) gene and ganciclovir (GCV) therapy for treatment of hepatocellular carcinoma cells (Huh 7) in an animal model.MethodsThe Huh 7/NTG stable cell line was established by transfection of a vector with the human sodium iodide symporter (hNIS), HSV1-sr39 thymidine kinase (tk), and enhanced green florescent protein (EGFP) fusion gene into Huh 7 cells. mRNA expressions of these genes were evaluated by RT-PCR analysis. The functions of hNIS and HSV1-sr39tk were verified with 125I uptake and 3H-penciclovir (PCV) uptake tests. EGFP and hNIS expression was confirmed with confocal microscopy after immunocytochemical staining. We treated the tumor cells with ANT2 shRNA or GCV or both ANT2 shRNA and GCV and treated the in vivo mouse model with a Huh 7/NTG tumor xenograft. The therapeutic effects of the in vivo study were assessed with caliper measurements and gamma camera imaging using 99mTc-pertechnetate.ResultsHuh 7/NTG cells showed a cell number-dependent increase in 125I uptake and a 24-fold higher 3H-PCV uptake compared to parent Huh 7 cells. Huh 7/NTG cells transfected with ANT2 shRNA had lower ANT2 mRNA expression and more impaired proliferation activity than cells transfected with scramble shRNA. Proliferation of Huh 7/NTG cells was also inhibited by GCV treatment. Combined GCV and ANT2 shRNA therapy further inhibited cell proliferation in the in vitro study. The combined therapy with GCV and ANT2 shRNA showed a further decrease in tumor growth in the mouse model.ConclusionsOur results suggest that the combined RNA interference with ANT2 and GCV therapy inhibited hepatocellular carcinoma cell proliferation more than single GCV therapy or ANT2 shRNA therapy in vitro and in vivo. Therefore it could be applied treating incurable hepatocellular carcinoma. 相似文献
143.
Jung Min Chang In Ae Park Su Hyun Lee Won Hwa Kim Min Sun Bae Hye Ryoung Koo Ann Yi Seung Ja Kim Nariya Cho Woo Kyung Moon 《European radiology》2013,23(9):2450-2458
Objective
To evaluate the correlation between stiffness values obtained by shear-wave elastography (SWE) and breast cancer subtypes.Methods
This was an institutional review board-approved retrospective study with a waiver of informed consent. The stiffness of 337 invasive breast cancers in 337 women was evaluated by SWE and mean stiffness values (kPa) and qualitative colour scores (1–5) of tumours were obtained. The results were analysed according to BI-RADS category, tumour size, grade and tumour subtype (triple-negative [TN], human epidermal growth factor receptor 2 [HER2]-positive, and oestrogen receptor [ER]-positive) using a multiple linear regression analysis.Results
The mean stiffness values and colour scores were: 146.8 kPa ± 57.0 and 4.1 ± 1.1; 165.8 kPa ± 48.5 and 4.6 ± 0.7 for TN tumours (n = 64), 160.3 kPa ± 56.2 and 4.3 ± 1.0 for HER2-positive tumours (n = 55) and 136.9 kPa ± 57.2 and 4.0 ± 1.1 for ER-positive tumours (n = 218; P < 0.0001). All three breast cancers classified as BI-RADS category 3 on B-mode ultrasound were TN subtype. A multiple linear regression analysis revealed that tumour size, histological grade and tumour subtype were independent factors that influenced the stiffness values.Conclusion
High stiffness values correlated with aggressive subtypes of breast cancer.Key points
? Shear-wave elastography is increasingly used to measure the stiffness of breast tumours. ? Triple-negative and HER2-positive tumours showed greater stiffness than ER-positive tumours. ? All breast cancers classified as BI-RADS 3 on B-mode ultrasound were triple-negative subtype. ? Tumour size, histological grade and subtype were independent factors influencing SWE stiffness. 相似文献144.
Hye Yeon Han Dong Jin Chung Kum Won Kim Cheol Mog Hwang 《Korean journal of radiology》2008,9(2):179-181
This report describes the color and pulsed Doppler US findings of penile Mondor's disease. The pulsed Doppler US findings of penile Mondor's disease have not been previously published, so we report here for the first time on the cavernosal arterial flow signal pattern of penile Mondor's disease. Penile Mondor's disease is rare disease that's characterized by thrombosis in the dorsal vein of the penis. The previous reports on penile Mondor's disease are concerned with the color Doppler US finding without the flow signals in this area, but these findings are insufficient to understand the hemodynamics in penile Mondor's disease. We report for the first time on a cavernosal artery flow signal pattern of low peak systolic velocity and high-resistance. 相似文献
145.
Needle tract implantation after percutaneous interventional procedures in hepatocellular carcinomas: lessons learned from a 10-year experience. 总被引:1,自引:0,他引:1
Samuel Chang Seong Hyun Kim Hyo K Lim Seung Hoon Kim Won Jae Lee Dongil Choi Young Sun Kim Hyunchul Rhim 《Korean journal of radiology》2008,9(3):268-274
Percutaneous interventional procedures under image guidance, such as biopsy, ethanol injection therapy, and radiofrequency ablation play important roles in the management of hepatocellular carcinomas. Although uncommon, the procedures may result in tumor implantation along the needle tract, which is a major delayed complication. Implanted tumors usually appear as one or a few, round or oval-shaped, enhancing nodules along the needle tract on CT, from the intraperitoneum through the intercostal or abdominal muscles to the subcutaneous or cutaneous tissues. Radiologists should understand the mechanisms and risk factors of needle tract implantation, minimize this complication, and also pay attention to the presence of implanted tumors along the needle tract during follow-up. 相似文献
146.
Background We compared outcomes of surgery and radiofrequency thermal ablation (RFA) in patients with metachronous liver metastases.
Methods Between October 1995 and December 2005, 59 patients underwent hepatic resection and 30 underwent RFA for metachronous liver
metastases. Patients with extra-hepatic metastases, those who underwent both types of treatment, and those with synchronous
hepatic metastasis were excluded.
Results The two groups had similar mean age, sex ratio, comorbid medical conditions, primary disease stage, and frequency of solitary
metastases. Preoperative mean serum carcinoembryonic antigen (CEA) level was significantly higher in the RFA group (13.4 ng/mL
vs. 7.7 ng/mL; p = 0.02). Mean diameter of hepatic metastases was significantly greater in the resection than in the RFA group (3.1 cm vs.
2.0 cm; p = 0.001). Recurrence after treatment of metastasis was observed in 18 of 30 (60.0%) RFA and 33 of 59 (56%) resection patients.
Local recurrence at the RFA site was observed in 7 of 30 (23%) patients. Time to recurrence (15 vs. 8 months, p = 0.02) and overall survival (56 vs. 36 months, p = 0.005) were significantly longer in the resection than in the RFA group. In the 69 patients with solitary metastases of
diameter ≤3 cm, time to recurrence (p = 0.004) and overall survival were significantly greater in the resection group.
Conclusions Compared with hepatic resection, RFA for metachronous hepatic metastases from colorectal cancer was associated with higher
local recurrence and shorter recurrence-free and overall survival rates, even in patients with solitary, small (≤3 cm) lesions. 相似文献
147.
Kim MS Lee SY Cho WH Song WS Koh JS Lee JA Yoo JY Jeon DG 《Annals of surgical oncology》2008,15(3):906-914
Background We assessed whether new parameter that considers both tumor volume change and necrosis rate predicts metastasis-free survival
of localized osteosarcoma patients. We also evaluated relationship between tumor volume change and necrosis rate or metastasis-free
survival.
Methods We retrospectively reviewed 151 patients with stage II osteosarcoma who were treated with surgery and neoadjuvant chemotherapy.
The tumor volume change was measured and calculated based on pre- and postchemotherapy magnetic resonance images. The mean
metastasis-free interval was 83.1 months. We calculated adjusted tumor necrosis rate as following formula: 100–(100–necrosis
rate) × postchemotherapy/prechemotherapy tumor volume. Survival and logistic regression analyses were used to evaluate the
correlation among size parameters, tumor necrosis rate and survival.
Results The 5-year metastasis-free survival rate of 151 patients was 71.4% (95% CI, 67.7–75.1%). American Joint Committee on Cancer
(AJCC) stage IIB (RR 2.27; 95% CI, 1.11–4.62; P = 0.025) and poor adjusted tumor necrosis rate (RR 2.02; 95% CI, 1.05–3.89; P = 0.035) independently correlated with metastasis-free survival period. Further, tumor volume change independently correlated
with necrosis rate. Decreased tumor volume could predict good response, with sensitivity of 80.2%, specificity of 68.6%, and
positive predictive value (PPV) of 74.7%. Increased or stable tumor volume could predict poor response, with sensitivity of
68.6%, specificity of 80.2%, and PPV of 75.0 %.
Conclusion The necrosis rate adjusted by the tumor volume change is an independent prognostic factor in osteosarcoma. This adjusted tumor
necrosis rate may serve as a basis for risk-adapted therapy in combination with other prognostic factors. 相似文献
148.
Chen Li Sungsoo Kim Ji Fu Lai Sung Jin Oh Woo Jin Hyung Won Hyuk Choi Seung Ho Choi Sung Hoon Noh 《Journal of gastrointestinal surgery》2008,12(3):550-554
The feasibility and diagnostic reliability of sentinel node (SN) biopsy for gastric cancer are still controversial. We studied
the clinicopathological features and localization of solitary lymph node metastasis (SLM) in gastric cancer to provide useful
information for use of the SN concept in gastric cancer. From 2000 to 2004, 3,267 patients with gastric cancer underwent D2
radical gastrectomy. The clinicopathological features of 195 patients with histologically proven SLM and the distribution
of metastasized nodes were assessed. The incidence of SLM was 6.0% in all cases. Compared with the node-negative patients,
significant differences were observed in age, tumor size, depth of invasion, and surgical type. The cumulative 5-year survival
rate of patients with SLM was 80.5%, which was significantly lower than 90.2% for node-negative patients (P < 0.001). Of patients with SLM, 82.6% had it in the perigastric node area (N1), and the other 17.4% patients had skip metastasis
in the N2-N3 nodes. Perigastric nodes were the most common first sites of drainage from the tumor, making them the main targets
of the operative SN mapping procedure. Due to the higher than expected incidence of skip metastasis in gastric cancer, D2
lymphadenectomy should be performed until the reliability of SN navigation surgery is validated in multicenter prospective
clinical trials. 相似文献
149.
Background and objectives In breast cancer, the expression pattern of CXCR4 may be correlated with the degree of axillary lymph node involvement. The
aim of this study was to evaluate the contributing factors that contribute to the correlation between CXCR4 expression and
axillary lymph node metastasis in breast cancer.
Methods Between August 1997 and August 2002, sections of paraffin-embedded tissue were obtained from 107 patients who received optimal
treatment for breast cancer. The expression of CXCR4 was evaluated by immunohistochemical staining.
Results A significant correlation was found in the expression of nuclear CXCR4 and lymph node metastasis (P = 0.03). We found a significant correlation between a high nuclear expression of CXCR4 and axillary lymphatic metastasis
in estrogen and progesterone receptor negative breast cancer (P = 0.01 and P = 0.01). There was a significant correlation between the high expression of nuclear CXCR4 and axillary lymphatic metastasis
in comparisons between positive estrogen and/or progesterone receptor expression and negative expression (P = 0.02).
Conclusions Our results showed that high expression of nuclear CXCR4 was significantly correlated with lymph node metastasis in breast
cancer. The high expression of nuclear CXCR4 in hormone receptor negative breast cancer was associated with a high possibility
of lymph node metastasis. 相似文献
150.
Chung TS Lim SB Sohn DK Hong CW Han KS Choi HS Jeong SY 《World journal of surgery》2008,32(10):2275-2280
BACKGROUND: The present study investigated the feasibility of a single-stage operation consisting of self-expandable metallic stent (SEMS) placement followed by laparoscopic surgery for obstructive left colorectal cancer. METHODS: From July 2002 to March 2007, 17 consecutive patients with primary obstructive left colorectal cancer underwent SEMS placement followed by laparoscopic surgery. Data were collected retrospectively regarding clinicopathological findings, SEMS placement, operative procedures, and perioperative outcomes. Technical success was defined as successful stent deployment across the obstructive lesion, and clinical success as the possibility of performing a single-stage operation without creating a stoma. RESULTS: In the laparoscopic group, the technical success rate was 100% (17/17) and there was no morbidity associated with SEMS placement. The median interval to laparoscopic surgery was 7 (range, 2-11) days, and the procedures included 11 anterior resections, 3 left hemicolectomies, 2 Hartmann's procedures, and 1 subtotal colectomy. All procedures were completed laparoscopically without conversion to open surgery. The median operating time was 178 (range, 93-377) minutes, and the median estimated blood loss was 100 (range, 50-400) ml with no cases requiring intraoperative transfusions. The clinical success rate was 82.4% (14/17), and there was no surgical morbidity other than two patients in whom chyloperitoneum and ileus were controlled by using conservative management. The median postoperative hospital stay was 9 (range, 7-49) days. CONCLUSIONS: A single-stage operation consisting of SEMS placement followed by laparoscopic surgery seems to be a feasible and safe treatment option for obstructive left colorectal cancer. 相似文献