全文获取类型
收费全文 | 403833篇 |
免费 | 24347篇 |
国内免费 | 846篇 |
专业分类
耳鼻咽喉 | 5498篇 |
儿科学 | 12977篇 |
妇产科学 | 12655篇 |
基础医学 | 59099篇 |
口腔科学 | 9681篇 |
临床医学 | 34590篇 |
内科学 | 78455篇 |
皮肤病学 | 7494篇 |
神经病学 | 30414篇 |
特种医学 | 15275篇 |
外国民族医学 | 46篇 |
外科学 | 63952篇 |
综合类 | 9398篇 |
现状与发展 | 2篇 |
一般理论 | 242篇 |
预防医学 | 28277篇 |
眼科学 | 9607篇 |
药学 | 28068篇 |
28篇 | |
中国医学 | 978篇 |
肿瘤学 | 22290篇 |
出版年
2021年 | 4283篇 |
2019年 | 4245篇 |
2018年 | 6242篇 |
2017年 | 4495篇 |
2016年 | 5208篇 |
2015年 | 6031篇 |
2014年 | 8054篇 |
2013年 | 12414篇 |
2012年 | 15907篇 |
2011年 | 16129篇 |
2010年 | 10268篇 |
2009年 | 9277篇 |
2008年 | 14986篇 |
2007年 | 16435篇 |
2006年 | 15973篇 |
2005年 | 15703篇 |
2004年 | 15206篇 |
2003年 | 14166篇 |
2002年 | 13759篇 |
2001年 | 14138篇 |
2000年 | 14284篇 |
1999年 | 12252篇 |
1998年 | 4369篇 |
1997年 | 3970篇 |
1996年 | 3611篇 |
1995年 | 3507篇 |
1994年 | 3192篇 |
1993年 | 2958篇 |
1992年 | 8883篇 |
1991年 | 8983篇 |
1990年 | 8734篇 |
1989年 | 8577篇 |
1988年 | 7777篇 |
1987年 | 7536篇 |
1986年 | 7174篇 |
1985年 | 7029篇 |
1984年 | 5478篇 |
1983年 | 4876篇 |
1982年 | 3455篇 |
1981年 | 2948篇 |
1979年 | 4877篇 |
1978年 | 3754篇 |
1977年 | 3306篇 |
1976年 | 2997篇 |
1975年 | 3256篇 |
1974年 | 3702篇 |
1973年 | 3695篇 |
1972年 | 3375篇 |
1971年 | 3127篇 |
1970年 | 3016篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
11.
12.
13.
14.
Amosova E. N. Shilova I. V. Zueva E. P. Rybalkina O. Yu. 《Pharmaceutical Chemistry Journal》2020,54(7):721-724
Pharmaceutical Chemistry Journal - Three extracts were produced from the above-ground part of the meadowsweet Filipendula ulmaria (L.) Maxim. using water, 40% ethanol, and 70% ethanol. Comparative... 相似文献
15.
Hui-Ju Ch’ang 《World journal of hepatology》2015,7(16):2029-2040
The success of sorafenib in prolonging survival of patients with hepatocellular carcinoma (HCC) makes therapeutic inhibition of angiogenesis a component of treatment for HCC. To enhance therapeutic efficacy, overcome drug resistance and reduce toxicity, combination of antiangiogenic agents with chemotherapy, radiotherapy or other targeted agents were evaluated. Nevertheless, the use of antiangiogenic therapy remains suboptimal regarding dosage, schedule and duration of therapy. The issue is further complicated by combination antiangiogenesis to other cytotoxic or biologic agents. There is no way to determine which patients are most likely respond to a given form of antiangiogenic therapy. Activation of alternative pathways associated with disease progression in patients undergoing antiangiogenic therapy has also been recognized. There is increasing importance in identifying, validating and standardizing potential response biomarkers for antiangiogenesis therapy for HCC patients. In this review, biomarkers for antiangiogenesis therapy including systemic, circulating, tissue and imaging ones are summarized. The strength and deficit of circulating and imaging biomarkers were further demonstrated by a series of studies in HCC patients receiving radiotherapy with or without thalidomide. 相似文献
16.
Hsiao-Hsuan Kuo Ran Fan Nina Dvorina Andres Chiesa-Vottero William M. Baldwin III 《Journal of the American Society of Nephrology : JASN》2015,26(4):855-863
Antibody-mediated rejection is a major complication in renal transplantation. The pathologic manifestations of acute antibody-mediated rejection that has progressed to functional impairment of a renal transplant have been defined in clinical biopsy specimens. However, the initial stages of the process are difficult to resolve with the unavoidable variables of clinical studies. We devised a model of renal transplantation to elucidate the initial stages of humoral rejection. Kidneys were orthotopically allografted to immunodeficient mice. After perioperative inflammation subsided, donor-specific alloantibodies were passively transferred to the recipient. Within 1 hour after a single transfer of antibodies, C4d was deposited diffusely on capillaries, and von Willebrand factor released from endothelial cells coated intravascular platelet aggregates. Platelet-transported inflammatory mediators platelet factor 4 and serotonin accumulated in the graft at 100- to 1000-fold higher concentrations compared with other platelet-transported chemokines. Activated platelets that expressed P-selectin attached to vascular endothelium and macrophages. These intragraft inflammatory changes were accompanied by evidence of acute endothelial injury. Repeated transfers of alloantibodies over 1 week sustained high levels of platelet factor 4 and serotonin. Platelet depletion decreased platelet mediators and altered the accumulation of macrophages. These data indicate that platelets augment early inflammation in response to donor-specific antibodies and that platelet-derived mediators may be markers of evolving alloantibody responses. 相似文献
17.
18.
19.
20.
Edward J. Holland Walter O. Whitley Kenneth Sall Stephen S. Lane Aparna Raychaudhuri Steven Y. Zhang 《Current medical research and opinion》2016,32(10):1759-1765
Objective: Report efficacy findings from three clinical trials (one phase 2 and two phase 3 [OPUS-1, OPUS-2]) of lifitegrast ophthalmic solution 5.0% for treatment of dry eye disease (DED).Research design and methods: Three 84-day, randomized, double-masked, placebo-controlled trials. Adults (≥18 years) with DED were randomized (1:1) to lifitegrast 5.0% or matching placebo. Changes from baseline to day 84 in signs and symptoms of DED were analyzed.Main outcome measures: Phase 2, pre-specified endpoint: inferior corneal staining score (ICSS; 0–4); OPUS-1, coprimary endpoints: ICSS and visual-related function subscale (0–4 scale); OPUS-2, coprimary endpoints: ICSS and eye dryness score (EDS, VAS; 0–100).Results: Fifty-eight participants were randomized to lifitegrast 5.0% and 58 to placebo in the phase 2 trial; 293 to lifitegrast and 295 to placebo in OPUS-1; 358 to lifitegrast and 360 to placebo in OPUS-2. In participants with mild-to-moderate baseline DED symptomatology, lifitegrast improved ICSS versus placebo in the phase 2 study (treatment effect, 0.35; 95% CI, 0.05–0.65; p?=?0.0209) and OPUS-1 (effect, 0.24; 95% CI, 0.10–0.38; p?=?0.0007). Among more symptomatic participants (baseline EDS ≥40, recent artificial tear use), lifitegrast improved EDS versus placebo in a post hoc analysis of OPUS-1 (effect, 13.34; 95% CI, 2.35–24.33; nominal p?=?0.0178) and in OPUS-2 (effect, 12.61; 95% CI, 8.51–16.70; p?<?0.0001).Limitations: Trials were conducted over 12 weeks; efficacy beyond this period was not assessed.Conclusions: Across three trials, lifitegrast improved ICSS in participants with mild-to-moderate baseline symptomatology in two studies, and EDS in participants with moderate-to-severe baseline symptomatology in two studies. Based on the overall findings from these trials, lifitegrast shows promise as a new treatment option for signs and symptoms of DED. 相似文献