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991.
Peter Arne Gerber Stephan Meller Tatiana Eames Bettina Alexandra Buhren Holger Schrumpf Sonja Hetzer Laura Maximiliane Ehmann Wilfried Budach Edwin B?lke Christiane Matuschek Andreas Wollenberg Bernhard Homey 《European journal of medical research》2012,17(1):4
Background
In recent years inhibitors directed against the epidermal growth factor receptor (EGFR) have evolved as effective targeting cancer drugs. Characteristic papulopustular exanthemas, often described as acneiform rashes, are the most frequent adverse effect associated with this class of novel cancer drugs and develop in > 90% of patients. Notably, the rash may significantly compromise the patients'' quality of life, thereby potentially leading to incompliance as well as dose reduction or even termination of the anti-EGFR therapy. Yet, an effective dermatologic management of cutaneous adverse effects can be achieved. Whereas various case reports, case series or expert opinions on the management of EGFR-inhibitor (EGFRI) induced rashes have been published, data on systematic management studies are sparse.Methods
Here, we present a retrospective, uncontrolled, comparative study in 49 patients on three established regimens for the management of EGFRI-associated rashes.Results
Strikingly, patients'' rash severity improved significantly over three weeks of treatment with topical mometason furoate cream, topical prednicarbate cream plus nadifloxacin cream, as well as topical prednicarbate cream plus nadifloxacin cream plus systemic isotretinoin.Conclusions
In summary our results demonstrate that EGFRI-associated rashes can be effectively managed by specific dermatologic interventions. Whereas mild to moderate rashes should be treated with basic measures in combination with topical glucocorticosteroids or combined regiments using glucocorticosteroids and antiseptics/antibiotics, more severe or therapy-resistant rashes are likely to respond with the addition of systemic retinoids. 相似文献992.
Platelet-mediated thrombotic complications in patients with ET: Reversal by aspirin, platelet reduction, and not by coumadin 总被引:1,自引:0,他引:1
Michiels JJ Berneman Z Schroyens W Koudstaal PJ Lindemans J van Vliet HH 《Blood cells, molecules & diseases》2006,36(2):199-205
The broad spectrum of aspirin-sensitive erythromelalgia, its microvascular ischemic complications, migraine-like atypical or typical transient ischemic attacks (cerebral and ocular) as well as acute coronary syndromes in thrombocythemia vera (essential thrombocythemia and thrombocythemia associated with polycythemia vera in maintained remission by phlebotomy) is caused by platelet cyclo-oxygenase-mediated arteriolar inflammation, fibromuscular intimal proliferation without and with occlusive thrombosis by platelet-rich thrombi in the end-arterial microvasculature of the peripheral, cerebral, ocular and coronary circulation. These microvascular ischemic and thrombotic complications does not respond to Coumadin, but are immediately relieved by a loading dose of 500 mg aspirin, and does not recur when the patient is maintained on low dose aspirin (50 mg per day) or after reduction of platelet counts to normal (<400.000/microl). 相似文献
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994.
Vandecasteele K Ost P Oosterlinck W Fonteyne V Neve WD Meerleer GD 《Phytotherapy research : PTR》2012,26(2):208-213
The purpose of this pilot study was to evaluate the efficacy and safety of Salvia officinalis in controlling hot flashes in prostate cancer patients treated with androgen deprivation therapy (ADT). Ten patients experiencing hot flashes were included in a single‐centre prospective pilot study. Treatment consisted of 150 mg of Salvia officinalis extract taken orally three times daily. A diary questionnaire scoring hot flashes, subjective side effects and quality of life (QOL) had to be completed. Clinical examination was performed at every visit and the concentration of ADT‐linked hormones, haemoglobin and cholesterol was measured before, during and after ending treatment. Before the start of treatment, a 1 week baseline registration was performed. An analysis of variance with time of measurement as a within‐subject factor was performed. When analysing the hot flashes score, one patient was excluded due to insufficient diary notes. The mean weekly score declined from 112 (SD = 71) at baseline to 59 (SD = 54) at the end of treatment (p = 0.002). Hot flashes diminished significantly from the first week up to and including week 3. This was maintained during treatment. There was no effect on QOL. There were no side effects. It is concluded that Salvia officinalis is efficient and safe in the treatment hot flashes, without improving QOL. Copyright © 2011 John Wiley & Sons, Ltd. 相似文献
995.
Anita Plenge-Bönig Nelís Soto-Ramírez Wilfried Karmaus Gudula Petersen Susan Davis Johannes Forster 《European journal of pediatrics》2010,169(12):1471-1476
To assess whether breastfeeding protects against acute gastroenteritis (AGE) due to rotavirus (RV) infection compared to RV-negative
AGE (RV−) in children age 0–12 months. Data from a community-based study of children with AGE from 30 pediatric practices
in Germany, Switzerland, and Austria were evaluated. A case–control design was conducted with RV-positive AGE (RV+) cases
and RV− AGE as controls. Odds ratios and 95% confidence intervals were estimated using log-linear regression models adjusting
for child’s age, family size, number of siblings, child care attendance, and nationality. A total of 1,256 stool samples were
collected from infants with AGE; 315 (25%) were RV+ and 941 RV−. Being breastfed in the period of disease inception reduced
the risk of AGE due to RV+ (OR, 0.53; 95% CI, 0.37–0.76). In infants 0–6 months of age, the protective effect was stronger
(OR, 0.33; 95% CI, 0.19–0.55) than in 7–12-month-old children. Our study adds to the evidence of a protective concurrent effect
of breastfeeding against rotavirus infection in infants, particularly in children 6 months and younger. Breastfeeding is important
to diminish rotavirus-related gastroenteritis in infants before vaccination can be introduced. 相似文献
996.
Michiels JJ Gadisseur A van der Planken M Schroyens W De Maeseneer M Hermsen JT Trienekens PH Hoogsteden H Pattynama PM 《Seminars in thrombosis and hemostasis》2006,32(7):678-693
The requirement for a safe diagnostic strategy should be based on an overall posttest incidence of venous thromboembolism (VTE) of less than 1%, with a negative predictive value of more than 99 to 100% during 3-month follow-up. Compression ultrasonography (CUS) and spiral computed tomography (CT) currently are the methods of choice to confirm or rule out deep venous thrombosis (DVT) and pulmonary embolism (PE), respectively. CUS has a negative predictive value (NPV) of 97 to 98%, indicating the need to improve the diagnostic work-up of patients with suspected DVT by clinical score assessment and D-dimer testing. Spiral CT as a stand-alone method detects all clinically relevant PEs and a large number of alternative diagnoses. It rules out PE with a NPV of 98 to 99%. Spiral CT is expensive, emphasizing the need to improve the diagnostic work-up of patients with suspected PE by the use of clinical score assessment and D-dimer testing. Clinical score assessment for DVT and PE has not safely ruled out VTE in multicenter studies and in routine daily practices. Modification of the Wells clinical score assessment for DVT by elimination of the "minus 2 points" for alternative diagnosis will improve the reproducibility of the clinical score assessment. The combination of a first negative CUS and a negative SimpliRed or an enzyme-linked immunosorbent assay (ELISA) VIDAS D-dimer of < 1,000 ng/mL safely exclude DVT (NPV > 99%) irrespective of clinical score assessment and without the need to repeat CUS in approximately 60 to 70% of patients. The rapid quantitative and qualitative agglutination D-dimer assays for the exclusion of VTE are not sensitive enough as stand-alone tests and should be used in combination with clinical score assessment. A normal rapid ELISA VIDAS D-dimer test as a stand-alone test safely excludes DVT and PE, with a NPV of 99 to 100%, irrespective of clinical score, without the need of CUS or spiral CT. The combined strategy of a rapid ELISA VIDAS D-dimer followed by objective testing with CUS for DVT and by spiral CT for PE will reduce the need for noninvasive imaging techniques by 40 to 50%. 相似文献
997.
Jézéquel P Campone M Gouraud W Guérin-Charbonnel C Leux C Ricolleau G Campion L 《Breast cancer research and treatment》2012,131(3):765-775
Gene prognostic meta-analyses should benefit from breast tumour genomic data obtained during the last decade. The aim was
to develop a user-friendly, web-based application, based on DNA microarrays results, called “breast cancer Gene-Expression
Miner” (bc-GenExMiner) to improve gene prognostic analysis performance by using the same bioinformatics process. bc-GenExMiner
was developed as a web-based tool including a MySQL relational database. Survival analyses are performed with R statistical
software and packages. Molecular subtyping was performed by means of three single sample predictors (SSPs) and three subtype
clustering models (SCMs). Twenty-one public data sets have been included. Among the 3,414 recovered breast cancer patients,
1,209 experienced a pejorative event. Molecular subtyping by means of three SSPs and three SCMs was performed for 3,063 patients.
Furthermore, three robust lists of stable subtyped patients were built to maximize reliability of molecular assignment. Gene
prognostic analyses are done by means of univariate Cox proportional hazards model and may be conducted on cohorts split by
nodal (N), oestrogen receptor (ER), or molecular subtype status. To evaluate independent prognostic impact of genes relative
to Nottingham Prognostic Index and Adjuvant! Online, adjusted Cox proportional hazards models are performed. bc-GenExMiner
allows researchers without specific computation skills to easily and quickly evaluate the in vivo prognostic role of genes
in breast cancer by means of Cox proportional hazards model on large pooled cohorts, which may be split according to different
prognostic parameters: N, ER, and molecular subtype. Prognostic analyses by molecular subtype may also be performed in three
robust molecular subtype classifications. 相似文献
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