Long-term visual outcome of transscleral laser cyclotherapy in eyes with ambulatory vision

OBJECTIVE: To determine the long-term visual acuity (VA) outcome of eyes with ambulatory vision (20/80 or better) that were treated with transscleral laser cyclotherapy. DESIGN: Observational case series. PARTICIPANTS: Twenty-one eyes of 21 patients who had been treated with laser cyclotherapy and who had been followed up at least 1 year. METHODS: A retrospective chart review was conducted to record the prelaser best-corrected VA and then the last available post laser VA and duration of follow-up. Additional laser or surgical interventions for glaucoma control were also recorded. MAIN OUTCOME MEASURES: Changes in VA from pretreatment to last available examination. RESULTS: The 21 eyes were followed for a mean of 40.7 months (range, 13-88 months); 17 eyes had a final vision within 1 line of the prelaser VA. One eye improved 3 lines, and 3 eyes deteriorated 3 or more lines. CONCLUSIONS: Most eyes with 20/80 or better VA maintained close to that acuity after laser cyclotherapy after a mean follow-up of 40.7 months. These good visual results offer support for those who believe that the indications for laser cyclotherapy should not be limited to eyes with poor VA or potential.     

Driving performance in patients with mild to moderate glaucomatous clinical vision changes

The purpose of this study was to determine the relationship between clinical measures of visual function and driving-related skills in patients with glaucoma who had good visual acuity in at least one eye and mild to moderate visual field loss. METHODS: Twenty-five patients with glaucoma and twenty-nine age-equivalent normally sighted control subjects were included in the study. We tested each patient on an interactive driving simulator and collected vision data, including Lighthouse visual acuity, Goldmann and Humphrey visual fields, and Pelli-Robson contrast sensitivity. Information about real-world accident history for the previous 5-year period was obtained. RESULTS: The glaucoma patients did not have significantly more simulator or real-world accidents than the normally sighted group. There were no significant differences between the groups in performance on seven of the eight simulator indexes that were measured. Of the clinical visual function measures, only lower contrast sensitivity in the eye with better contrast sensitivity correlated with driving skills, including slower speeds (r(24) = 0.58, p < or = 0.01), more lane boundary crossings (r(24) = -0.54, p < or = 0.01), and longer braking response times (r(24) = -0.60, p < or = 0.01) for the patient group. CONCLUSION: Reduced contrast sensitivity may be important in indicating the level of driving skills for individuals with glaucoma, who have normal or near-normal visual acuity and mild to moderate visual field loss.     

Evidence That Emotional Maladjustment Is Worse in Men Than in Women with Psychogenic Nonepileptic Seizures

The purpose of this study is to examine the effects of gender on adjustment and cognition in patients with psychogenic nonepileptic seizures (NES) and on patients with epilepsy. We compared 57 women and 27 men, all at least 16 years old, with only NES as documented by long-term EEG-video monitor studies, to equal numbers of randomly selected women and men with only epileptic seizures. Variables examined included age, age of onset, education, scales from the MMPI, the WAIS-R, and the number of tests outside normal limits from the Neuropsychological Battery for Epilepsy. We found no significant differences in mean age, intelligence, or percentage of neuropsychological tests outside normal limits across the four groups. Women and men with NES had significantly later age of onset of attacks compared with subjects of either gender with epilepsy (26 years vs 13 years, P < 0.001) and men with NES had greater educational achievement than women with NES or patients with epilepsy (P < 0.02). However, the most important findings were seen on the MMPI. Men with NES exhibited significantly greater elevations on multiple scales (especially Hysteria, Depression, Hypochondriasis, Psychoasthenia, Schizophrenia) compared with men with epilepsy or women with either epilepsy or NES. We conclude that men with NES have significantly worse patterns of emotional adjustment, as measured by the MMPI, than women with NES or subjects of either gender with epilepsy.     

The medical civic action program in Vietnam: success or failure?

Medical services have long been an integral part of the military and warfare. Civilians, however, are also caught up in wars. This article discusses the care of the indigenous civilians by U.S. military medical personnel during the Vietnam War. Civilian medical care is rendered both for altruistic purposes and to satisfy the policy aims of the U.S. government. Evaluation of these two aspects of the programs does not lead to the same conclusions. Doctors doubted the value of the programs, whereas the command structure was enthusiastic. For a program to be of sustained value to the people, it must persist over time and train those who will remain after U.S. forces are withdrawn. This did not occur in Vietnam. Furthermore, I doubt that medical care rendered by U.S. troops in uniform can serve to build up loyalty to another organization, such as the host government.     

Surgical versus non-surgical endodontic re-treatment for periradicular lesions

Background : Though success rates of endodontic initial treatment have been improving over the years, persistence of periapical disease is far from being a rare condition. The most common therapeutical options for the re‐treatment of teeth with periapical pathosis are non‐surgical orthograde treatment and surgical treatment. Selection between alternative treatments should be based on assessment of respective benefits (mainly healing) and risks from studies consistent with a high level of evidence. Objectives : To test the null hypothesis of no difference in outcome between surgical and non‐surgical therapy for endodontic re‐treatment of periradicular lesions. Search strategy : The Cochrane Oral Health Group Trials Register, CENTRAL, MEDLINE and EMBASE were searched with appropriate search strategies. Handsearching included eight dental journals. The bibliographies of relevant clinical trials and relevant articles were checked for identifying studies outside the handsearched journals. Seven manufacturers of instruments in the field of endodontics or endodontic surgery or both, as well as the authors of the identified randomized controlled trials (RCTs) were contacted in order to identify unpublished or ongoing RCTs. No language restriction was placed. The last electronic search was conducted on 3rd April 2007. Selection criteria : All RCTs about re‐treatment of teeth with periapical pathosis in which both surgical and non‐surgical approaches were used and having a follow up of at least 1 year were considered for the analysis. Data collection and analysis : A quality assessment of the included RCTs was carried out and the authors were contacted for missing information. We independently extracted the data in duplicate. We followed the Cochrane Oral Health Group's statistical guidelines. Main results : Three RCTs were identified, two of them reporting different data from the same clinical study. The risk of bias was judged as moderate for one study and high for the other one. One hundred and twenty‐six cases were followed up for at least 1 year, and 82 had a follow up of 4 years. At the 1‐year follow up the success rate for surgical treatment was slightly better than non‐surgical (risk ratio (RR) 1.13; 95% confidence interval (CI) 0.98 to 1.30). When the follow up was extended to 4 years (only one RCT made it) the outcome for the two procedures became similar. Authors' conclusions : The finding that healing rates can be higher for cases treated surgically as compared to those treated non‐surgically, at least in the short term, is based on two RCTs only. A single RCT reported that in the medium to long term healing rates for the two procedures are very similar. There is currently scarce evidence for a sound decision making process among alternative treatments for the re‐treatment of a periradicular pathosis. More well‐designed RCTs should be performed with follow up of at least 4 years, and with a consistent sample size, to detect a true difference in the long term between the outcomes of the two alternative treatments, if any exist.     

Common bile duct stones: reassessment of criteria for CT diagnosis

To evaluate the specificity of previously suggested computed tomographic (CT) criteria for diagnosing common bile duct (CBD) stones, CT scans of 38 patients with CBD stones were compared with scans of 32 patients with carcinoma obstructing the CBD and 28 nonobstructed patients. The CBD stone was directly visualized as a target sign or densely calcified structure in 29 of 38 patients with stones (76%); one with carcinoma showed a similar target sign. A rim of increased density in the distal CBD was found without accompanying target sign in six patients with stones (16%), compared with 12 with carcinoma (38%) and 15 nonobstructed patients (54%). Irregular intraluminal densities without a detectable target sign were noted in four patients with stones (11%), compared with eight with carcinoma (25%) and nine nonobstructed patients (32%). Abrupt termination of the CBD without a mass was more common as an isolated finding in patients with carcinoma (31%) than in patients with stones (13%). CT is accurate in detecting CBD stones in certain patient populations, but direct visualization of the stone is required.