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排序方式: 共有255条查询结果,搜索用时 15 毫秒
71.
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L G Cohen J Prince J Biederman T Wilens S V Faraone S Whitt E Mick T Spencer M C Meyer D Polisner J G Flood 《Pharmacotherapy》1999,19(6):746-752
We conducted a retrospective chart review to examine the pharmacokinetic interaction between desipramine and the stimulants methylphenidate and dexedrine using routinely monitored desipramine serum concentrations in children receiving desipramine either alone or with a stimulant. Subjects were 142 children and adolescents (age 6-17 yrs; 113 taking desipramine, 29 taking desipramine-stimulants) in whom 401 dose- and weight-normalized serum concentrations were evaluated (333 desipramine, 68 desipramine-stimulants). Desipramine pharmacokinetic parameters were similar for both groups, including mean weight-corrected dose (3.66+/-1.36 mg/kg, desipramine; 3.66+/-1.09 mg/kg, desipramine-stimulants; p=0.97), weight- and dose-normalized serum concentrations (47.26+/-39.26 [microg/L]/[mg/kg], desipramine, 39.02+/-19.92 [microg/L]/[mg/kg], desipramine-stimulants; p=0.09), and clearance (0.690+/-0.913 [L/kg]/hr, desipramine; 0.613+/-0.514 [L/kg]/hr, desipramine-stimulants; p=0.499). When stratified by age, gender, and type of stimulant, no difference was detected (p>0.05) between groups. Our findings indicate the absence of a clinically significant interaction between desipramine and stimulants. 相似文献
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Catrine Tudor-Locke Barbara E Ainsworth Melicia C Whitt Raymond W Thompson Cheryl L Addy Deborah A Jones 《Revue canadienne de physiologie appliquée》2003,28(5):699-709
The purpose of this study was to explore the relationship between objectively determined ambulatory activity and simple cardiorespiratory parameters (heart rate and blood pressure at rest and during submaximal exercise) in individuals who were stratified for self-reported participation (yes/any vs. no/none) in vigorous physical activity (PA). Ninety-eight subjects (African Americans: 7 M, 16 F; Caucasians: 33 M, 42 F; mean age 46.4 +/- 15.4 yrs; mean BMI 26.7 +/- 4.8) wore a pedometer for 21 consecutive days and completed a 10-min submaximal treadmill graded exercise test with HR (beats/min) and BP (mmHg) measured while walking at 4.8 km/hr and a 10% grade. Subjects averaged 7,618 +/- 3.045 steps/day. There were no differences in steps/day by self-reported vigorous PA strata. There was an inverse relationship (r = -0.35, p = 0.03) between steps/day and resting HR in subjects who reported no vigorous PA. There was an inverse relationship (r = -0.22, p = 0.04) between steps/day and submaximal HR in all subjects. When stratified for self-reported vigorous PA, the inverse relationship between steps/day and submaximal HR was stronger for those reporting no vigorous PA (r = -0.39, p = 0.01) vs. those reporting any vigorous PA (r = -0.28, p = 0.05). There was no relationship between steps/day and BP at rest or during exercise in this normotensive sample. 相似文献
75.
Prahalad Umachigi Sanjay G S Kumar KN Jayaveera Kumar DV Kishore Kumar CK Ashok R Dhanapal 《African journal of traditional, complementary, and alternative medicines》2007,4(4):481-487
Anthocephalus cadamba (Roxb.) Miq. Syn A. chinensis (Lamk) A. Rich (Rubiaceae) is ethnomedicinally widely used in the form of paste by tribe in western Ghats for treating skin diseases. In this context, antimicrobial potential of A. cadamba against a wide range of microorganisms was studied. To validate the ethnotherapeutic claims of the plant in skin diseases, wound healing activity was studied, besides antioxidant activity to understand the mechanism of wound healing. The alchoholic and aqueous extract of this plant showed significant antibacterial and antifungal activity against almost all the organisms: Micrococcus luteus, Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, and four fungi Candida albicans, Trichophyton rubrum—dermatophyte fungi, Aspergillus niger, Aspergillus flavus and Aspergillus nidulans—systemic fungi, with especially good activity against the dermatophyte (Trichophyton rubrum) and some infectious bacteria (Escherichia coli, Proteus mirabilis and Staphylococcus aureus) with an MIC of 2.5 µg/disc. The results show that A. cadamba extract has potent wound healing capacity as shown from the wound contraction and increased tensile strength. The results also indicated that A. cadamba extract possesses potent antioxidant activity by inhibiting lipid peroxidation and increase in the superoxide dismutase (SOD) and catalase activity. 相似文献
76.
Neuer A; Lam KN; Tiller FW; Kiesel L; Witkin SS 《Human reproduction (Oxford, England)》1997,12(5):925-929
Recent evidence suggests that Chlamydia trachomatis can persist in the
female upper genital tract in an unculturable state. Since unsuspected C.
trachomatis infection has been associated with adverse in-vitro
fertilization (IVF) outcome we sought to detect further evidence of C.
trachomatis in the genital tracts of women undergoing IVF. The prevalence
and distribution of antibodies to the major structural proteins of C.
trachomatis in paired follicular fluid and sera of women undergoing IVF
were examined. Sera and follicular fluid samples from 149 women were
assayed for immunoglobulin (Ig)G and IgA antibodies to two C. trachomatis
antigens, the major outer membrane protein (MOMP) and a recombinant
lipopolysaccharide (rLPS) fragment. Additionally, the expression of human
60 kDa heat shock protein (hsp 60) in follicular fluid was determined. All
cervical and follicular fluid samples were negative for C. trachomatis by
polymerase chain reaction, ligase chain reaction and DNA probe. Sera from
60% of the subjects were positive for antichlamydial rLPS IgG; 36% were
positive for anti-MOMP IgG. Similarly, rLPS-directed and MOMP-directed IgA
were detected in sera of 34 and 14% of the subjects respectively. IgG
antibodies to MOMP and rLPS were detected in 42 and 41% of the follicular
fluid examined respectively. Anti-MOMP IgA was identified in 8.7% of the
follicular fluid while 27.5% were positive for anti-rLPS IgA. Human hsp 60
expression was documented in 11.6% of the follicular fluid tested. IgA
antibodies to both MOMP (P = 0.03) and rLPS (P = 0.02) in follicular fluid
were associated with a failure to become pregnant after embryo transfer.
IgG antibodies in sera and follicular fluid and IgA antibodies in sera were
unrelated to IVF outcome. Similarly only anti- MOMP IgA (P = 0.02) and
anti-rLPS IgA (P = 0.04) in follicular fluid were correlated with human hsp
60 expression in follicular fluid. The unique association between IgA
antibodies to two chlamydial antigens in follicular fluid and both hsp 60
expression and IVF failure provides further support for the possibility
that a persistent upper genital tract chlamydial infection contributes to
IVF failure in some women.
相似文献
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Most ophthalmologic disorders reported with renal cystic disease have been associated with either medullary cystic disease or juvenile nephrophthisis. A family we investigated demonstrated two previously unreported autosomal dominant disorders: adult polycystic kidney disease and lattice corneal dystrophy. 相似文献