Ultrasonics Sonochemistry Assisted Preparation of Polysiloxane Main‐Chain Liquid‐Crystalline Elastomers

For the first time, an ultrasonics sonochemistry method is developed to promote the one‐pot hydrosilylation polyaddition polymerization and crosslinking reaction in the preparation of polysiloxane main‐chain liquid‐crystalline elastomers (MC‐LCEs). Due to the extraordinary effect of acoustic cavitation, the polyaddition polymerization and crosslinking reaction can be successfully carried out in an ordinary laboratory ultrasonic cleaner at room temperature, and generates the LCE matrix network in about 30 min. The prepared MC‐LCEs demonstrate good quality, good properties, and stimuli‐actuation performances. Compared to the traditional thermal processing methods for preparing polysiloxane MC‐LCEs, this method exhibits superior properties rapidly, with high convenience and efficiency, and can be a path for batch fabrication at low cost. The work also demonstrates that the ultrasonics sonochemistry method is effective in generating linear main‐chain liquid crystal polymers through hydrosilylation polyaddition and polysiloxane side‐chain LCE matrix through hydrosilylation crosslinking reaction, thus confirming the high availability of ultrasonics sonochemistry in the processes of hydrosilylation polymerization, crosslinking reactions, or synchronous polymerization and crosslinking reactions.     

ETCO2 waveforms-assisted awake nasal fibreoptic intubation

Journal of Clinical Monitoring and Computing - Awake fibreoptic intubation has always been considered the gold standard for expected difficult airway management. However, the use of fibreoptic...     

三黄搽剂治疗慢性湿疹临床观察

目的 探讨三黄搽剂在慢性湿疹治疗中的临床效果及其对血清免疫因子水平的影响.方法 选择2018年2月—2020年2月海丰县妇幼保健院慢性湿疹患者112例作为研究对象,随机分为对照组(56例)和观察组(56例).对照组采用常规治疗,观察组采用三黄搽剂治疗,治疗后对患者效果进行评估,比较2组患者治疗效果、2组患者治疗后相关症...     

陕产金柴胡总黄酮的含量测定及薄层鉴别

目的 测定金柴胡中总黄酮含量,并对其中三个黄酮成分进行薄层鉴别。方法采用薄层色谱法对金柴胡药材中的芦丁、槲皮素、异鼠李素进行了定性鉴别;采用紫外分光光度法测定不同产地金柴胡中总黄酮的含量。结果薄层鉴别斑点清晰,重复性好,金柴胡中总黄酮平均含量为3．993％。结论该方法简便可行,重复性好,可作为金柴胡药材的质量控制方法。     

基于真实世界的藤黄健骨片治疗膝骨关节炎患者临床特征及用药分析

目的：基于“藤黄健骨片治疗膝骨关节炎病例注册登记研究”的方法探索真实世界中藤黄健骨片治疗膝骨关节炎患者的临床特征及用药规律,分析中成药治疗膝骨关节炎的优势环节与用药特点。方法：选取2019年9月至2021年1月注册登记研究资料中全国43家医院2 505例患者数据,分析患者总体及不同分期的临床特征、用药规律。结果：2 505例患者中女1 717例,男788例,缓解期2 439例,发作期66例,康复期0例,平均年龄（60.54±6.80）岁,平均体质量指数（24.05±2.74）kg/m2,K-L分级多为Ⅱ级。藤黄健骨片最常用时长为8周,单次剂量3～6片,2次/d,平均总用药量（444.41±164.72）片,发生不良反应33例,合并疾病的膝骨关节炎患者452例,单用藤黄健骨片1 471例,联合用药1 034例,临床上常联用药物类别为西药口服、中成药口服、西药关节腔注射、中成药外用等;不同分期间的患者年龄、合并疾病比较,差异有统计学意义（P<0.05）。结论：真实世界中藤黄健骨片治疗膝骨关节炎人群女性多于男性,K-L分级以Ⅱ级分布为主,分期主要以缓解期为主,发作期在更高年龄占比更大;藤黄健骨片的用法用量与专家共识一致,临床联合用药类别主要为西药口服、中成药口服、西药关节腔注射、中成药外用等,具有良好的安全性。     

川芎油对脑缺血再灌注损伤大鼠的保护作用

目的：观察川芎油口服给药对脑缺血再灌注损伤大鼠的保护作用。方法：线栓法建立大鼠局灶性脑缺血再灌注损伤（MCAO）模型，脑缺血2小时、再灌注后22小时检测大鼠神经功能评分和脑梗死灶体积，测定各组大鼠脑组织匀浆中一氧化氮（NO）、超氧化物歧化酶（SOD）和丙二醛（MDA）的含量。结果：川芎油能明显改善脑缺血再灌注损伤大鼠神经功能，减小脑梗死灶体积，降低脑组织匀浆中NO、MDA含量。结论：川芎油对大鼠脑缺血再灌注损伤有显著的保护作用，其作用可能与抗氧化有关。     

电刺激对背根节神经元/Schwann细胞联合培养体系髓鞘蛋白P0表达的影响

目的:建立体外背根节神经元与Schwann细胞联合培养模型,观察短时低频电刺激对Schwann细胞髓鞘蛋白表达的影响。方法:培养和纯化背根节神经元与Schwann细胞,制成背根节神经元/Schwann细胞联合培养体系。于L-ascorbic acid诱导的同时,施予低频电刺激(20Hz,100μs,3V),持续作用1h,分别于L-ascorbicacid诱导后第0,2,4,8和10d取各组培养基上清以ELISA测定其中脑衍生物神经生长因子(BDNF)的水平。另外,于诱导后第7d和14d检测培养体系中髓鞘蛋白P0的表达。结果:电刺激组各时间点BDNF的浓度较对照组显著升高(P0.01)。经电刺激作用后,联合培养体系中P0表达上调(P0.05)。然而,电刺激结束后在培养液中加入TrkB-Fc,P0的表达水平则显著降低(P0.05)。结论:在神经元存在的条件下,短时低频电刺激可促进离体Schwann细胞合成P0,初步认为该作用通过刺激神经元分泌BDNF增多所致。     

麻醉期心率变异性的分形特性分析

采用关联维数、分形维数、尺度指数分析38例受试者麻醉期心率变异性信号的分形特性。结果表明:麻醉期心搏周期有显著性的分形特性变化,麻醉状态下心率变异性信号的关联维数(P<0.000001)明显低于清醒状态,而短时程尺度指数α1(P<0.0001)显著性地高于清醒状态。说明了麻醉期心率变异性信号的分形特性有明显地变化,提示运用非趋势波动分析方法分析麻醉期心率变异性信号的分形特性更适合于临床麻醉深度监测。     

Design and synthesis of pH-sensitive polymeric micelles for oral delivery of poorly water-soluble drugs

pH-sensitive polymer poly (polylactide-co-methacrylic acid)–b-poly (acrylic acid) was synthesized using atom transfer radical polymerization and ring-opening polymerization and characterized by gel permeation chromatography and ¹H NMR. The polymers can self-assemble to form micelles in aqueous medium, which respond rapidly to pH change within the gastrointestinal relevant pH range. Critical micelle concentrations and pH response behavior of the polymeric micelle were investigated. Water-insoluble drug nifedipine was loaded and the drug-loading content can be controlled by tuning the composition of the polymers. The in vitro release studies indicate pH sensitivity enabled rapid drug release at the environment of simulated intestinal fluid (pH 7.36), the cumulative released amount of NFD reached more than 80% within 24 h, while only 35% in the simulated gastric fluid (pH 1.35). All the results showed that the pH-sensitive P(PLAMA-co-MAA)–b-PAA micelle may be a prospective candidate as oral drug delivery carrier for hydrophobic drugs with controlled release behavior.