Novel poly(arylene ether ketone)/poly(ethylene glycol)-grafted poly(arylene ether ketone) composite microporous polymer electrolyte for electrical double-layer capacitors with efficient ionic transport

Polymer electrolytes have attracted considerable research interest due to their advantages of shape control, excellent safety, and flexibility. However, the limited use of traditional polymer electrolytes in electric double-layer capacitors due to their unsatisfactory ionic conductivities and poor mechanical properties makes them difficult to operate for long periods of time in large-scale energy storage. Therefore, we fabricated a high-performance microporous electrolyte based on poly(arylene ether ketone) (PAEK)/poly(ethylene glycol)-grafted poly(arylene ether ketone) (PAEK-g-PEG) using a certain amount of carboxylated chitosan with a high electrolyte uptake rate of 322 wt% and a high ionic conductivity of 2 × 10⁻² S cm⁻¹ at room temperature. A symmetric solid-state supercapacitor that uses activated carbon as electrodes and a composite microporous polymer film as the electrolyte shows a high specific capacitance of 134.38 F g⁻¹ at a current density of 0.2 A g⁻¹, while liquid electrolytes demonstrate a specific capacitance of 126.92 F g⁻¹. Energy density of the solid-state supercapacitor was 15.82% higher than that of the liquid supercapacitor at a current density of 5 A g⁻¹. In addition, the solid-state supercapacitor exhibited excellent cycling stability of over 5000 charge/discharge cycles at a current density of 1 A g⁻¹. Furthermore, solid-state supercapacitors display lower self-discharge behavior with an open-circuit potential drop of only 36% within 70 000 s, which is significantly better than that of conventional supercapacitors (52% @ 70 000 s), at a charging current density of 1 mA cm⁻². The satisfactory results indicated that the PAEK/PAEK-g-PEG composite microporous polymer film demonstrates high potential as an electrolyte material in practical applications of solid-state and portable energy storage devices.

Polymer electrolytes have attracted considerable research interest due to their advantages of shape control, excellent safety, and flexibility.     

Mesoporous adsorbent for competitive adsorption of fluoride ions in zinc sulfate solution

Al–La hybrid gel was constructed using an innovative acid-catalyzed and calcination free sol–gel formation process which only included a sol–gel process lasting for 30 min and a drying procedure at 150 °C. This novel material was used as an adsorbent for competitive adsorption of fluoride ions in zinc sulfate solution. The properties, optimal adsorption conditions, synthetic principle and adsorption mechanism of the material were systemically investigated. The results showed that γ-AlO(OH) composed the skeleton of the Al–La hybrid gel and La(CH₃COO)₃ was embedded in the framework, which formed large amounts of ink-bottle type mesopores. A high fluoride ion adsorption rate with the removal rate reaching 50.88% within 1 min at 50 °C, 3 g L⁻¹ was obtained. Analysis of the adsorption data has demonstrated that the adsorption of fluoride ions by the Al–La hybrid gel followed pseudo-second-order kinetics. Moreover, both Langmuir and Freundlich models can describe the adsorption process well. The maximum adsorption capacity of the Al–La hybrid adsorbent was 28.383 mg g⁻¹. Furthermore, the mechanism analysis results indicated that the fluoride ions were mainly removed by the electrostatic adsorption on the AlO(OH), and a small amount of fluoride ions was also adsorbed by the complexation of lanthanum and fluoride ions. Since both AlO(OH) and La(CH₃COO)₃ had a large number of fluoride ion adsorption sites, the Al–La hybrid gel obtained an ideal adsorption capacity. In addition, the adsorption rate was greatly enhanced by the capillary action existing from the initial to the final stage of adsorption.

Al–La hybrid gel was prepared using an innovative acid-catalyzed and calcination free sol–gel process, and showed excellent adsorption performance for fluoride ions in zinc sulfate solution.     

三黄搽剂治疗慢性湿疹临床观察

目的 探讨三黄搽剂在慢性湿疹治疗中的临床效果及其对血清免疫因子水平的影响.方法 选择2018年2月—2020年2月海丰县妇幼保健院慢性湿疹患者112例作为研究对象,随机分为对照组(56例)和观察组(56例).对照组采用常规治疗,观察组采用三黄搽剂治疗,治疗后对患者效果进行评估,比较2组患者治疗效果、2组患者治疗后相关症...     

自发性颈内动脉海绵窦瘘临床诊治研究进展

颈内动脉海绵窦瘘（CCF）是一种临床少见的脑血管疾病,以外伤性原因导致的CCF多发,自发性CCF因其起病隐匿,临床症状不明显,容易导致误诊、漏诊。对自发性CCF的诊治目前主要依据临床经验总结,缺乏规范的诊治规范指南。近年来,随着自发性CCF病例报道逐渐增多,综合病例报道分析,现将自发性CCF临床诊治方面进行综述。     

microRNA-34c-3p在浸润性乳腺癌中的表达及其与BRCA基因的关系

目的分析浸润性乳腺癌microRNA-34c-3p(miR-34c-3p)的表达及其与BRCA基因突变的相关性。 方法选取2015年2月至2017年6月在空军医科大学西京医院初次就诊的患者作为研究对象进行前瞻性研究。根据纳入条件,将患者分为浸润性乳腺癌组(55例)、乳腺癌前病变组(46例)和正常对照组(50例),分别检测miR-34c-3p在各组组织标本和血液标本中的表达水平。采用单因素方差分析比较3组间miR-34c-3p表达水平的差异,组间两两比较采用LSD法;并用Spearman秩相关分析法分析浸润性乳腺癌组织标本和血液标本中miR-34c-3p表达水平与BRCA基因突变的相关性。 结果(1)在乳腺组织标本中,浸润性乳腺癌组、乳腺癌前病变组、正常对照组miR-34c-3p表达水平分别为0.76±0.29、1.24±0.33和1.62±0.36,3组比较,差异有统计学意义(F＝27.373,P＝0.020),其中,浸润性乳腺癌组miR-34c-3p表达水平明显低于乳腺癌前病变组和正常对照组(P＝0.024、0.001),乳腺癌前病变组与正常对照组比较,差异无统计学意义(P＝0.065)。(2)在血液标本中,浸润性乳腺癌组、乳腺癌前病变组、正常对照组miR-34c-3p表达水平分别为0.32±0.18、0.71±0.23和0.93±0.27,3组比较,差异有统计学意义(F＝29.534,P＝0.018),其中,浸润性乳腺癌组miR-34c-3p表达水平明显低于正常对照组(P＝0.006),但浸润性乳腺癌组与乳腺癌前病变组比较、乳腺癌前病变组与正常对照组比较,miR-34c-3p表达水平的差异均无统计学意义(P＝0.076、0.102)。(3)miR-34c-3p在乳腺癌组织中的表达水平与BRCA基因突变风险呈负相关(r＝－0.548,P<0.001);血液标本中,miR-34c-3p表达水平与BRCA基因突变风险也呈负相关(r＝－0.312,P＝0.006)。 结论miR-34c-3p在浸润性乳腺癌组织中低表达,且与BRCA基因突变存在一定的联系。     

内毒素缓释大鼠的持续发热模型研究

目的:建立细菌脂多糖(lipopolysaccharide,LPS)缓释所致大鼠持续发热的模型。方法:制备LPS浓度为0.01～2mg/ml的胶原水凝胶,固化后以生理盐水浸泡,基质显色法测定LPS的日释放量,研究其体外释放过程;大鼠皮下注射LPS含量为0.02～4mg的胶原水凝胶,测定12d内肛温,研究LPS皮下缓释对大鼠体温的影响。大鼠皮下注射LPS含量为2mg的胶原水凝胶,分别于注射后2、8h及1、3、12d测定其血浆中肿瘤坏死因子α(TNF-α)浓度和肺组织中胞浆型磷脂酶A2α(cPLA2α)浓度,研究其对发热及炎性肺损伤相关细胞因子的影响。结果:LPS载入胶原水凝胶后可在12d内持续释放,除首日释放量高于次日约30～50%外,日释放量相对稳定,且与载入量呈正相关;大鼠皮下注射载LPS的胶原水凝胶后可出现不同程度和过程的发热,其中0.02、0.2mg组仅出现一过性发热,而2、4mg组尚可观察到持续12d的发热反应;发热过程中血液TNF-α浓度和肺组织cPLA2α浓度均有不同程度升高。结论:采用载LPS胶原水凝胶皮下注射可复制大鼠持续发热模型,可作为复制不同阶段温病-炎性肺损伤大鼠模型的基础。     

流式细胞术检测抗中性粒细胞抗体方法的建立及临床初步应用

目的建立适用于临床的流式细胞术（FCM）检测抗中性粒细胞抗体（ANA）的方法,并作临床初步应用。方法采用FCM,以前向散射和侧向散射参数区分全血标本中的淋巴细胞和粒细胞,设定粒细胞门,用CD16b-藻红蛋白（PE）和CD177-别藻蓝蛋白（APC）单克隆抗体分别检测中性粒细胞中表面表达CD16b和CD177抗原细胞的百分率。用所建方法检测健康对照32名,确定参考范围,以此作为判断受检者血液中抗CD16b或CD177抗体存在与否的依据。检测外周血白细胞（WBC）总数〈4.0×109/L且中性粒细胞绝对计数（ANC）〈2.8×109/L的59例患者的CD16b和CD177百分率,并对其中中性粒细胞表达CD16b和/或CD177百分率低于参考范围（即判为相应抗体阳性）的患者给予激素治疗,观察疗效。结果健康人群中性粒细胞中表达CD16b和CD177的百分率分别为98.36%±1.53%和74.95%±11.07%,据此分别确定了健康人群中性粒细胞表达CD16b和CD177的参考范围分别为CD16b〉95.36%、CD177〉53.25%（即〉x珋-1.96s）。59例患者中有23例（39.0%）ANA阳性,其中ANC〈2.0×109/L患者的ANA阳性率（50.0%）远高于ANC〉2.0×109/L患者（27.6%）。ANA阳性患者经激素治疗后,WBC和ANC上升。结论 FCM检测抗中性粒细胞CD16b和CD177抗体是自身免疫性中性粒细胞减少症（AIN）实验简便、快捷的诊断方法,有助于AIN的诊断、鉴别诊断和疗效判断。     

568例基层医院急性肾衰竭患者病因及其危险因素分析

目的：分析基层医院急性肾衰竭（ARF）的病因,寻找影响其预后的危险因素,为降低ARF发病率,提高临床疗效,判断预后提供参考。方法：以2007年6月～2009年6月就诊于温岭市第一人民医院等4个基层医院的ARF患者为研究对象,归纳引起ARF的病因;将其分为治愈组、好转组、无效组和死亡组,首先采用单因素分析方法初步筛查出危险因素,然后将初筛的危险因素进一步使用二分类Logistic回归法做多因素分析,判别各因素对死亡危险度的影响。结果：（1）301224例住院患者中,ARF患者568例（占0.19%）;其中男366例（占64.45%）,女202例（占35.56%）,男女之比1.8∶1。（2）568例ARF患者中,按照肾性、肾前性和肾后性分类方法,以肾性ARF最常见,共282例（占49.65%）,肾前性ARF140例（占24.65%）,肾后性ARF146例（占25.70%）。按照引起ARF的原因分类,肾实质损害和梗阻所占比例最大,分别为22.89%和21.65%,其次是感染和药物因素,分别占11.97%和9.15%。（3）多脏器功能衰竭（MODS）、高血钾及贫血是导致ARF预后差的危险因素。结论：ARF发病率为0.19%,男性多于女性,除肾原性原因外,肾后梗阻、感染和药物性肾损害是最常见原因。MODS、贫血、高血钾是影响预后的危险因素。     

胰岛素泵和甘精胰岛素在2型糖尿病患者围手术期的疗效及费用的比较

目的:比较胰岛紊泵和甘精胰岛素在2型糖尿病(T2DM)患者围手术期控制血糖选标时间及低血糖的发生率及费用的差别.方法:将80例围手术期T2DM患者分为胰岛素泵治疗组(CSII组)42例,甘精胰岛素治疗组(G组)38例.比较各组患者血糖达标时间及低血糖的发生率及费用的差别.结果:CSII组和G组在血糖达标时间及低血糖发生率上无明显差别,而G组在费用方面明显低于CSII组.结论:胰岛素泵及甘精胰岛素在T2DM患者围手术期均能安全、有效、快速、平稳降低血糖,且甘精胰岛素费用较低.