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71.
Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy. 总被引:7,自引:0,他引:7 下载免费PDF全文
M Spindler K W Saupe M E Christe H L Sweeney C E Seidman J G Seidman J S Ingwall 《The Journal of clinical investigation》1998,101(8):1775-1783
An arginine to glutamine missense mutation at position 403 of the beta-cardiac myosin heavy chain causes familial hypertrophic cardiomyopathy. Here we study mice which have this same missense mutation (alphaMHC403/+) using an isolated, isovolumic heart preparation where cardiac performance is measured simultaneously with cardiac energetics using 31P nuclear magnetic resonance spectroscopy. We observed three major alterations in the physiology and bioenergetics of the alphaMHC403/+ mouse hearts. First, while there was no evidence of systolic dysfunction, diastolic function was impaired during inotropic stimulation. Diastolic dysfunction was manifest as both a decreased rate of left ventricular relaxation and an increase in end-diastolic pressure. Second, under baseline conditions alphaMHC403/+ hearts had lower phosphocreatine and increased inorganic phosphate contents resulting in a decrease in the calculated value for the free energy released from ATP hydrolysis. Third, hearts from alphaMHC403/+ hearts that were studied unpaced responded to increased perfusate calcium by decreasing heart rate approximately twice as much as wild types. We conclude that hearts from alphaMHC403/+ mice demonstrate work load-dependent diastolic dysfunction resembling the human form of familial hypertrophic cardiomyopathy. Changes in high-energy phosphate content suggest that an energy-requiring process may contribute to the observed diastolic dysfunction. 相似文献
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Dr. med. H. Saupe 《Archives of orthopaedic and trauma surgery》1944,43(2-4):440-454
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Langendor Quastler Wette Reisner v. Spindler Lenkeit Arthur Hintze Engelmann H. Neumann Saupe du Mesnil de Rochemont W. Teske du Mesnil de Rochemont Isola Glauner H. Fuchs Th. Pütz Spaar Sandera 《Journal of cancer research and clinical oncology》1939,49(2):134-144
Ohne Zusammenfassung 相似文献
75.
Reg.-Gewerberat Dr. Elisabeth Krüger Prof. Rostoski Prof. Saupe 《International archives of occupational and environmental health》1931,2(3):558-590
Ohne Zusammenfassung 相似文献
76.
Stadtmedizinalrat Professor E. Saupe 《Journal of molecular medicine (Berlin, Germany)》1930,9(29):1352-1356
Ohne Zusammenfassung 相似文献
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White adipose tissue is a promising source of mesenchymal stem cells. Currently, little is known about the effect of age and
caloric restriction (CR) on adipose-derived stem cells (ASC). This is important for three reasons: firstly, age and CR cause
extensive remodeling of WAT; it is currently unknown how this remodeling affects the resident stem cell population. Secondly,
stem cell senescence has been theorized as one of the causes of aging and could reduce the utility of a stem cell as a reagent.
Thirdly, the mechanism by which CR extends lifespan is currently not known, one theory postulates that CR maintains the resident
stem cell population in youthful “fit” state. For the purpose of this study, we define ASC as lineage negative (lin−)/CD34+(low)/CD31−. We show that aging increases the abundance of ASC and the expression of Cdkn2a 9.8-fold and Isl1 60.6-fold. This would suggest
that aging causes an accumulation of non-replicative ASC. CR reduced the percentage of ASC in the lin− SVF while also reducing colony forming ability. Therefore, CR appears to have anti-proliferative effects on ASC that may
be advantageous from the perspective of cancer, but our data raises the possibility that it may be disadvantageous for regenerative
medicine applications. 相似文献
80.
Katja Saupe reas Widmann Alexandra Bendixen Matthias M. Müller Erich Schröger 《Psychophysiology》2009,46(2):321-327
The aim of the present study was to simultaneously measure and compare intermodal attention effects in event-related brain potentials (ERPs) and auditory steady-state responses (ASSRs). For this purpose, 40-Hz amplitude modulated tones and a visual fixation cross were presented concurrently. By means of target detection tasks either on the sounds or on the fixation cross, participants' attention was directed to the respective modality. Attended sounds elicited a negative difference (Nd) in the ERP relative to unattended sounds. Nd was divided into an early and a late part as often observed for intramodal attention. Moreover, attention to the sounds led to a significant enhancement of the ASSR. This modulation of the ASSR by intermodal attention is demonstrated for the first time in the EEG. The present data suggest that ASSRs could provide a useful tool for the investigation of the neural dynamics of intermodal attentional processes. 相似文献