Cross-cultural invariance of the Academic Expectations Stress Inventory: Adolescent samples from Canada and Singapore

We provide further evidence for the two-factor structure of the 9-item Academic Expectations Stress Inventory (AESI) using confirmatory factor analysis on a sample of 289 Canadian adolescents and 310 Singaporean adolescents. Examination of measurement invariance tests the assumption that the model underlying a set of scores is directly comparable across groups. This study also examined the cross-cultural validity of the AESI using multigroup confirmatory factor analysis across both the Canadian and Singaporean adolescent samples. The results suggested cross-cultural invariance of form, factor loadings, and factor variances and covariances of the AESI across both samples. Evidence of AESI's convergent and discriminant validity was also reported. Findings from t-tests revealed that Singaporean adolescents reported a significantly higher level of academic stress arising from self expectations, other expectations, and overall academic stress, compared to Canadian adolescents. Also, a larger cross-cultural effect was associated with academic stress arising from other expectations compared with academic stress arising from self expectations.     

单侧分布线状和漩涡状痣样过度黑素沉着病

报告1例单侧分布线状和漩涡状痣样过度黑素沉着病.患儿男,10岁.右侧躯干、四肢出现线状及旋涡状色素沉着斑8年,而部、掌跖、指(趾)甲、口腔黏膜、外阴未见类似皮损,患儿出现弱视5年.     

上海浦东新区静脉产业类生态工业园区规划设想

分析了上海浦东新区固体废物处置现状及存在问题、面临的机遇,提出利用有限土地资源,将生活垃圾和其它特殊固体废物集中在园区内进行无害化处理和资源化利用,构建静脉产业链,建设符合《静脉产业类生态工业园区标准》的生态工业园区.     

Antifungal and Anticancer Activities of a Protein from the Mushroom Cordyceps militaris

The mushroom Cordyceps militaris has been used for a long time in eastern Asia as a nutraceutical and in traditional Chinese medicine as a treatment for cancer patients. In the present study, a cytotoxic antifungal protease was purified from the dried fruiting bodies of C. militaris using anion-exchange chromatography on a DEAE-Sepharose column. Electrophoretic analyses indicated that this protein, designated C. militaris protein (CMP), has a molecular mass of 12 kDa and a pI of 5.1. The optimum conditions for protease activity were a temperature of 37℃ and pH of 7.0~9.0. The enzyme activity was specifically inhibited by the serine protease inhibitor phenylmethylsulfonyl fluoride. Amino acid composition of intact CMP and amino acid sequences of three major peptides from a tryptic digest of CMP were determined. CMP exerted strong antifungal effect against the growth of the fungus Fusarium oxysporum, and exhibited cytotoxicity against human breast and bladder cancer cells. These results indicate that C. militaris represents a source of a novel protein that might be applied in diverse biological and medicinal applications.     

鼻腔给药制剂——脂质体的研究概述

本文通过对脂质体及NDDS的阐述,介绍了脂质体在NDSS中的应用及优势。探讨了脂质体在NDSS中的作用机制,介绍脂质体作为鼻腔药物载体的研究现状,展望脂质体纳米化是脂质体鼻腔给药药物的发展趋势。     

HPLC梯度洗脱法同时测定决明子中橙黄决明素、大黄素、大黄酚和大黄素甲醚的含量

目的:采用HPLC梯度洗脱法同时测定决明子中橙黄决明素、大黄素、大黄酚和大黄素甲醚的含量.方法:用Kromasil 100A C18色谱柱(5μm,4.6mm×150mm,迪马公司);甲醇-0.1%磷酸溶液梯度洗脱:0～15min(65:35),15～16 min(65～85:35～15),16～40 min(85:15);柱温:室温;检测波长:285nm(0～15min),254nm(15～40min);流速:1mL·min-1.结果:橙黄决明素、大黄素、大黄酚和大黄素甲醚的线性范围分别为0.00038～0.00608μg(r=0.9998)、0.0029～0.0464μg(r=0.9999)、0.00105～0.0168μg(r=0.9996)、0.00044～0.00704μg(r=0.9998),平均回收率分别为99.50%(RSD=0.71%)、99.59%(RSD=1.42%)、99.31%(RSD=0.59%)、99.74%(RSD=0.91%).结论:本方法专属性强,重复性好,可用于决明子中橙黄决明素、大黄素、大黄酚和大黄素甲醚的含量测定.     

中西医结合治疗膝关节骨性关节炎(肝肾亏虚型)临床观察

目的 观察正清风痛宁关节腔注射配合六味地黄汤内服治疗肝肾亏虚型膝骨性关节炎的临床疗效.方法 120例随机分为3组.治疗组40例用正清风痛宁关节腔注射配合六味地黄汤内服治疗,对照1组40例用正清风痛宁进行膝关节腔注射,对照2组40例用六味地黄汤加减内服.3组均治疗30天,停药后观察2月.结果 治疗组总有效率为92.5%,对照1组总有效率为72.5%,对照2组总有效率为62.5%,治疗组与对照1组和对照2组比较,均有显著性差异(P＜0.05).结论 正清风痛宁关节腔注射配合六味地黄汤内服治疗肝肾亏虚型膝骨性关节炎疗效肯定.     

浅谈当前农村药械违法特点及监管策略

崇明县作为上海市唯一的郊县,在药械的生产、经营和使用方面存在自身特点.通过对历年来崇明县药械违法案件进行分析,查找其违法特点和内在成因.为探索农村特色的药械监管道路,确保农村地区的药械市场安全可控进行了一些有益的探索.     

Expression of a peroxisome proliferator-activated receptor gamma 1 splice variant that was identified in human lung cancers suppresses cell death induced by cisplatin and oxidative stress.

PURPOSE: The activation of peroxisome proliferator-activated receptor gamma (PPAR gamma) has been implicated in the inhibition of tumor progression in lung cancers through the induction of differentiation and apoptosis. Recently, we identified a novel splice variant of human PPAR gamma1 (hPPAR gamma1) that exhibits dominant-negative activity in human tumor-derived cell lines. This study aimed to examine the expression and pathophysiologic roles of a truncated splice variant of hPPAR gamma1 (hPPAR gamma1(tr)) in primary human lung cancer tissues. EXPERIMENTAL DESIGN: The expression and localization of hPPAR gamma1(tr) was surveyed in human primary lung cancer tissues using immunohistochemistry and Western blot analysis. Using transfectants stably expressing wild-type hPPAR gamma1 (hPPAR gamma1(wt)) and hPPAR gamma1(tr), we also analyzed the pathophysiologic roles of hPPAR gamma1(tr). RESULTS: We showed that PPAR gamma is expressed predominantly in the nucleus of nontumorous tissues, whereas it is present in both the nucleus and the cytoplasm of tumorous tissues in squamous cell carcinoma (SCC) of the lung. Western blot analysis confirmed the presence of PPAR gamma1(tr) in primary lung SCC tissue but not in nontumorous tissue. Expression of PPAR gamma1(tr) in Chinese hamster ovary cells attenuated their susceptibility to cell death induced by oxidative stress or cisplatin, whereas their susceptibility was completely recovered by down-regulation of PPAR gamma1(tr) with small interfering RNA. CONCLUSIONS: hPPAR gamma1(tr) is expressed strongly in tumorous tissues of primary human lung SCC and its overexpression renders transfected cells more resistant to chemotherapeutic drug- and chemical-induced cell death. These data suggest that the decreased drug sensitivity of PPAR gamma1(tr)-expressing cells may be associated with increased tumor aggressiveness and poor clinical prognosis of patients.     

"旴江医学"印象

旴江名医众多，著述浩繁，研究江西“旴江医学”的源流特色、医家及学术特点等相关论述，有一定的现实意义。