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A Aynsley-Green SR Bloom DH Williamson RC Turner 《Archives of disease in childhood》1977,52(4):291-295
The hormonal and metabolic response to the first feed of breast milk was studied in 12 infants at 4-6 hours of age. After the feed there was an increase in blood glucose concentration but no changes in the concentrations of lactate, pyruvate, alanine, or ketone bodies. The feed was followed by an increase in the concentrations of plasma insulin, growth hormone, gastrin, and enteroglucagon, but no change in levels of plasma glucagon or gastric inhibitory peptide. Several hormone systems are functionally active at birth and are stimulated by the first feed of milk. 相似文献
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Modulation of implantation-associated integrin expression but not uteroglobin by steroid hormones in an endometrial cell line 总被引:2,自引:0,他引:2
Widra EA; Weeraratna A; Stepp MA; Stillman RJ; Patierno SR 《Molecular human reproduction》1997,3(7):563-568
In order to test the hypothesis that integrin and uteroglobin (UG)
expression in cultured endometrial cells are affected by hormone treatment,
Ishikawa-CH endometrial cancer cells were cultured and exposed to
oestradiol or oestradiol and progesterone regimens and assayed using
immunohistochemistry. We evaluated the intensity of immunohistochemical
staining for the integrin monomers alpha(v) and beta1, the dimers
alpha(v)beta3 and alpha(v)beta6, and for the secretory protein uteroglobin
under various experimental conditions. Cells grown in control media stained
positively for the integrin monomers alpha(v) and beta1, the dimer
alpha(v)beta3, and for UG. Oestradiol and sequential
oestradiol/progesterone reversibly suppressed staining for the dimer
alpha(v)beta3. Hormone treatment had no effect on the staining of the beta1
and alpha(v) monomers or UG. The alpha(v)beta6 dimer antibody did not stain
under any experimental treatment conditions. These data indicate that
expression of the integrin complex alpha(v)beta3 is reversibly suppressed
by oestradiol in Ishikawa cells and that these cells may be a good model
for studying hormone-driven molecular changes in endometrium.
相似文献
35.
羽叶三七叶中甙类成分的研究 总被引:3,自引:0,他引:3
从羽叶三七叶中分离到十三种甙类成分,经FAB-MS,13CNMR谱,双照射1HN-MR谱,1H-1H COSY谱及与标准品直接对照,证明十一种为已知化合物,分别为人参皂甙F1(Ⅰ),F2(Ⅱ),F3(Ⅲ),Rg2(Ⅳ),Ra(Ⅴ),Rd(Ⅵ),Rb1(Ⅷ),Rb3(Ⅷ),24(S)-假人参甙F11(Ⅸ),人参黄酮(Ⅹ)和珠子参甙F1(Ⅺ);另外两种为新的达玛烷型皂甙,命名为羽叶三七甙F1(Ⅻ)和F2(ⅫⅠ),并确定其化学结构。同时修正珠子参甙F3的结构。进一步阐明人参黄酮甙结构中的两个糖的连接方式。 相似文献
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Jon O Curwen Helen L Musgrove Jane Kendrew Graham H P Richmond Donald J Ogilvie Stephen R Wedge 《Clinical cancer research》2008,14(10):3124-3131
PURPOSE: Inhibition of vascular endothelial growth factor-A (VEGF) signaling is a key therapeutic approach in oncology given the role of VEGF in angiogenesis and vascular permeability in solid tumors. Clinical trials examining VEGF signaling inhibitors commonly report hypertension. We examined the effect of cediranib, a highly potent VEGF signaling inhibitor, on the blood pressure of rats and the ability of standard antihypertensive agents to modulate the consequences of VEGF signaling inhibition. EXPERIMENTAL DESIGN: The ability of cediranib to induce hypertensive changes and the effect of giving antihypertensive therapy were investigated in conscious, unrestrained telemetered rats. Two antihypertensive agents were studied: captopril, an angiotensin-converting enzyme inhibitor, and nifedipine, a dihydropyridine calcium channel blocker. The antitumor activity of cediranib, alone and in combination with nifedipine, was also evaluated in a LoVo human colorectal tumor xenograft model in nude rats. All treatments were given orally. RESULTS: Administration of 0.1 to 1.5 mg/kg/d of cediranib for 4 consecutive days induced a relatively mild hypertensive effect, elevating diastolic blood pressure by 10 to 14 mmHg. Dosing 3 mg/kg/d cediranib for 4 days induced a marked hypertension of 35 to 50 mmHg. Captopril (30 mg/kg, qd) was effective at lowering a 10 mmHg increase in blood pressure but not a 35 to 50 mmHg increase. However, the latter was rapidly reversed by administration of nifedipine (10 mg/kg, bd). Coadministration of nifedipine did not negatively affect the antitumor activity of cediranib (1.5 mg/kg/d). CONCLUSIONS: Hypertension is a direct consequence of inhibiting VEGF signaling but can be controlled with appropriately selected, standard antihypertensive medication. 相似文献
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