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991.
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993.
This study evaluated the effects of the cationic manganese(III) tetrakis(N,N'-diethylimidazolium-2-yl)porphyrin catalytic antioxidant Mn(III)TDE-2-ImP5+ (AEOL 10150) on outcome from spinal cord compression (SCC) in the mouse. C57BL/6J mice were subjected to 60 min thoracic SCC after discontinuation of halothane anesthesia. In Experiment 1, mice were given intravenous Mn(III)TDE-2-ImP5+ (0.5 mg/kg bolus followed by 1 mg kg(-1) h(-1) for 24 h), methylprednisolone (30 mg/kg bolus followed by 5.4 mg kg(-1) h(-1) for 24 h), or vehicle (n = 25 per group). In Experiment 2, mice were given intrathecal Mn(III)TDE-2-ImP5+ (2.5 or 5.0 microg/kg) or vehicle (n = 18 per group). In both experiments, treatment began 5 min post-SCC onset. Rotarod performance was measured on post-SCC days 3, 7, 14, and 21. On post-SCC day 21, the spinal cord was histologically examined and a total damage score was calculated. Neither intravenous Mn(III)TDE-2-ImP5+ nor methylprednisolone altered rotarod performance (accelerated rate P = 0.11, fixed rate P = 0.11) or mean +/- S.D. total damage score (Mn(III)TDE-2-ImP5+ = 21 +/- 9, methylprednisolone = 24 +/- 8, vehicle = 22 +/- 10; P = 0.47; shams = 0). Intrathecal Mn(III)TDE-2-ImP5+ (both 2.5 and 5.0 microg) given at SCC-onset improved rotarod performance (P = 0.05) and total damage score (2.5 microg = 19 +/- 10, P = 0.04; 5.0 microg =19 +/- 8, P = 0.03) versus vehicle (26 +/- 10). These studies demonstrate sustained benefit from manganese(III) porphyrin catalytic antioxidant therapy after SCC. However, efficacy was dependent upon route of administration suggesting that bioavailability is critical in defining efficacy. 相似文献
994.
Tumor immunity to murine plasma cell tumors. II. Essential role of T lymphocytes in immune response 总被引:3,自引:0,他引:3
Spleen cells, thoracic duct lymphocytes and adherent peritoneal exudate cells from mice immunized to syngeneic plasma cell tumors were capable of transferring specific protective immunity to these tumors. Pre-treatment of these cells with anti-Θ serum or anti-lymphocyte serum, but not with anti-ΘK serum, effectively abolished the ability of lymphoid cells to transfer this immune response. These studies demonstrate that T cells are essential in the adoptive transfer of immunity. Furthermore, immunization of athymic (nude) mice to plasma cell tumors was not achieved. Attempts to activate normal macrophages in vitro with sensitized lymphoid cells were unsuccessful. Admixture of immune lymphoid cells and target tumor cells to unrelated tumor cells did not inhibit the growth of the unrelated tumor cells. It is proposed that the immune response to syngeneic tumor associated antigens of plasma cell tumors not only involves essential sensitization of T lymphocytes, but that activated cytotoxic T lymphocytes are directly responsible for inhibiting target tumor growth. 相似文献
995.
John Ernst Molly H. Warner Anne Morgan Brenda D. Townes John Eiler David B. Coppel 《Archives of clinical neuropsychology》1986,1(4):309-314
A factor analysis of the Wechsler Memory Scale (WMS) with 30-minute delayed recall scores (percent retained) for the Logical Memory, Visual Reproduction, and Associate Learning subtests indicated that this variant of the WMS taps different types of learning and memory for new material. With regard to the verbal learning/recall subtests, Logical Memory appears to be related to attention/ concentration ability, while Associate Learning is relatively independent. The results also showed that both the easy and hard items from Associate Learning tap the same ability, providing evidence that this subtest is a measure of rote verbal learning. These results support the clinical utility of the WMS with delayed recalls in neuropsychiatric populations. 相似文献
996.
BACKGROUND: A unique way of determining patterns of parent-offspring transmission of risk to affective disorders is to focus on aggregation within sibling pairs. We attempt to extend our previous finding that sibling aggregation is notable for anxiety disorders in a 10-year follow-up of siblings at high and low risk for depression, by virtue of parental diagnosis. METHODS: The sample, which included 173 unique sibling pairs in the high risk cohort, and 83 pairs in the low risk cohort, had been assessed using semi-structured clinical interviews three times over a 10-year period, spanning from childhood to adulthood. Sibling aggregation was quantified using pairwise odds ratios. RESULTS: Sibling aggregation in the high risk cohort was greater than aggregation in the low risk cohort for anxiety disorders, especially those that emerged in childhood, and later co-morbid disorders, especially major depressive disorder and suicide attempts. CONCLUSIONS: Familial liability to affective disorders may be reflected most strongly by a developmental sequence of anxiety disorders in childhood followed by later depressive and suicidal in adolescence and adulthood. 相似文献
997.
Effects of H-2 haplotype and gender on the lifespan of A and C57BL/6 mice and their F1, F2, and backcross offspring 总被引:1,自引:0,他引:1
The effects of H-2 type and gender on the lifespan of A and C57BL/6 mice and their F1, F2, and backcross offspring were studied. The proportion of mice remaining alive, percent survivors, was calculated at monthly intervals for each mating group. Statistical analyses of these survival data showed that, in agreement with studies from other laboratories, C57BL/6 (H-2b) mice lived significantly longer than A (H-2a) mice. When the survival curves for A and C57BL/6 backcross and F2 offspring were analyzed to test for the presence of an H-2 effect on mouse lifespan, no statistically significant association was detected, although a trend toward increased 10th decile survivorship among female H-2a mice was noted. The mice used in this study were also evaluated for the presence of an effect of gender on lifespan. Female mice of the A strain, and F1, F2, and backcross groups, but not the C57BL/6 mice, exhibited significantly longer lifespans when compared with their male counterparts. Thus these data show a significant gender effect, but only a trend towards an H-2 effect, on the lifespan of A and C57BL/6 mice and their F1, F2, and backcross offspring. 相似文献
998.
999.
Sook K. Lim Calvin C. Sampson Oswald G. Warner 《Journal of the National Medical Association》1981,73(5):413-417
Two separate primary carcinomas occurring simultaneously in the esophagus and stomach are uncommon. The authors report three cases of this entity, squamous cell carcinoma of the osophagus and adenocarcinoma of the stomach, one of which is classified as a collision carcinoma of the stomach. Because of the rarity of collision tumors of this histologic variety, the world literature was reviewed. Diagnostic features and the relative prognosis of dual primary carcinomas are discussed. 相似文献
1000.
Echo L. Warner Brynn Fowler Laura Martel Deanna Kepka 《Journal of community health》2017,42(5):911-920