Influence of ambulatory blood pressure-related indicators within 24 h on in-hospital death in sepsis patients

Background: Sepsis is a serious public health problem worldwide. Blood pressure is one of the indicators that is closely monitored in intensive-care units, and it reflects complex interactions between the internal cardiovascular control mechanism and the external environment. We aimed to determine the impact of indicators related to the ambulatory blood pressure on the prognosis of sepsis patients.Methods: This retrospective study was based on the Medical Information Mart for Intensive Care IV database. Relevant information about sepsis patients was extracted according to specific inclusion and exclusion criteria. Examined parameters included the average blood pressure, blood pressure variability (BPV), and circadian rhythm, and the study outcome was in-hospital death. We investigated the effects of these indicators on the risk of in-hospital death among sepsis patients using Cox proportional-hazards models, restricted cubic splines analysis, and subgroup analysis.Results: This study enrolled 10,316 sepsis patients, among whom 2,117 died during hospitalization. All parameters except the nighttime variation coefficient of the diastolic blood pressure (DBP) were associated with in-hospital death of sepsis patients. All parameters except for fluctuations in DBP exhibited nonlinear correlations with the outcome. The subgroup analysis revealed that some of the examined parameters were associated with in-hospital death only in certain subgroups.Conclusion: Indicators related to the ambulatory blood pressure within 24 h are related to the prognosis of sepsis patients. When treating sepsis, in addition to blood pressure, attention should also be paid to BPV and the circadian rhythm in order to improve the prognosis and the survival rate.     

婚姻状况与癌症的关联研究进展

近30年来,全球癌症负担持续上升,且人口呈现出老龄化、少子化、结婚率下降及离婚率上升的趋势。婚姻是最亲密和长期的社会关系之一,既往研究零散报告了其对癌症发病和死亡的影响,缺乏基于人群高质量流行病学关联研究证据的系统梳理。本文对既往婚姻状况与癌症的关联研究进行综述,以期为未来相关研究以及癌症防控提供新思路。     

梅毒螺旋体部分外膜蛋白的研究现状

梅毒临床表现多种多样,传染性较强。由于梅毒螺旋体无法体外培养,使梅毒致病机制的研究较为困难。随着分子生物学技术的发展及梅毒螺旋体基因组序列全面解析,有关梅毒致病机制的研究取得了一定进展。梅毒螺旋体的外膜蛋白是其重要的毒力因子,是宿主保护性免疫的重要靶位。     

临床药师参与耐甲氧西林金黄色葡萄球菌骨髓炎伴肾功能亢进患儿的治疗实践

目的:探讨临床药师在儿童耐甲氧西林金黄色葡萄球菌(MRSA)骨髓炎个体化抗感染治疗中的作用.方法:临床药师通过会诊1例万古霉素治疗儿童急性骨髓炎失败的病例,根据患者临床情况及相关检查结果,并结合国内外文献,从PK/PD角度对万古霉素治疗失败的原因进行分析,提出万古霉素治疗失败后替代治疗方案.结果:临床药师提出的治疗方案...     

High house dust mite serum-specific immunoglobulin E indicates a high 5-year rhinitis-asthma conversion rate: a cross-sectional study

<正>Allergic rhinitis (AR) is a costly and highly prevalent chronic disease now.[1] More seriously, many patients with AR also have allergic asthma (AA). The presence of AR is a risk factor for the develo     

成人跖疣人乳头瘤病毒分型及与临床特征的关系

目的 检测成人跖疣乳头瘤病毒(HPV)型别,并探讨HPV分型与临床特征的关系.方法 采用PCR扩增、基因测序和TA克隆技术检测221例跖疣患者疣体的HPV型,记录患者的年龄、病程、症状和疣体数.结果 221例标本中,HPV阳性率为97％(215/221).单一HPV型占96％(206/215),HPV 27、2、57和7(Alpha属)分别占44.7％ (92/206)、12.1％(25/206)、7.3％(15/206)和0.5％(1/206);HPV 65(Gamma属)占0.5％(1/206);HPV 1、63(Mu属)占33.5％ (69/206)和1.5％ (3/206).HPV 27、2和57三型感染者之间年龄、病程、疣体个数、疼痛发生率和性别比较,差异均无统计学意义.与HPV 27感染者相比,HPV 1感染者与年龄≤30岁、病程≤1年、疣体数≤2个和疼痛高发生率相关.结论 HPV 27、2、57和1是感染成人跖疣患者的主要HPV型.HPV型与患者的临床特征间存在相关性.     

天然免疫相关细胞因子在人类真菌感染中的作用

研究表明,白细胞介素?1β、4、6、10、12、17、23,肿瘤坏死因子α和干扰素γ等天然免疫相关细胞因子在人类真菌感染过程中具有重要作用.它们在介导天然免疫反应的同时又可以通过诱导Th0细胞的分化类型而调节适应性免疫反应,对真菌感染的转归产生了巨大的影响.依照"病原真菌?天然免疫细胞?细胞因子?靶细胞?生物学效应"这一条真菌感染的天然免疫反应主线,逐个梳理主要天然免疫相关细胞因子在人类真菌感染过程中的细胞来源、基本功能及其相互间作用,列举并分析各种原因造成其功能异常时所导致的真菌感染性疾病,可为人类真菌感染性疾病寻找更多的治疗靶点.