全文获取类型
收费全文 | 247038篇 |
免费 | 60884篇 |
国内免费 | 8570篇 |
专业分类
耳鼻咽喉 | 2926篇 |
儿科学 | 6815篇 |
妇产科学 | 5366篇 |
基础医学 | 31797篇 |
口腔科学 | 8255篇 |
临床医学 | 45049篇 |
内科学 | 47729篇 |
皮肤病学 | 9329篇 |
神经病学 | 20798篇 |
特种医学 | 7420篇 |
外国民族医学 | 48篇 |
外科学 | 30260篇 |
综合类 | 25463篇 |
现状与发展 | 29篇 |
一般理论 | 46篇 |
预防医学 | 17375篇 |
眼科学 | 5601篇 |
药学 | 22437篇 |
154篇 | |
中国医学 | 9991篇 |
肿瘤学 | 19604篇 |
出版年
2024年 | 516篇 |
2023年 | 2976篇 |
2022年 | 5712篇 |
2021年 | 8965篇 |
2020年 | 11012篇 |
2019年 | 15253篇 |
2018年 | 15517篇 |
2017年 | 16823篇 |
2016年 | 16852篇 |
2015年 | 19179篇 |
2014年 | 20957篇 |
2013年 | 21893篇 |
2012年 | 16937篇 |
2011年 | 17893篇 |
2010年 | 18805篇 |
2009年 | 13885篇 |
2008年 | 11975篇 |
2007年 | 10618篇 |
2006年 | 10130篇 |
2005年 | 9030篇 |
2004年 | 6823篇 |
2003年 | 6265篇 |
2002年 | 5479篇 |
2001年 | 4982篇 |
2000年 | 4340篇 |
1999年 | 3776篇 |
1998年 | 2203篇 |
1997年 | 2170篇 |
1996年 | 1831篇 |
1995年 | 1730篇 |
1994年 | 1429篇 |
1993年 | 951篇 |
1992年 | 1302篇 |
1991年 | 1159篇 |
1990年 | 1004篇 |
1989年 | 845篇 |
1988年 | 742篇 |
1987年 | 645篇 |
1986年 | 538篇 |
1985年 | 488篇 |
1984年 | 332篇 |
1983年 | 298篇 |
1982年 | 196篇 |
1981年 | 203篇 |
1979年 | 248篇 |
1978年 | 189篇 |
1977年 | 169篇 |
1976年 | 147篇 |
1974年 | 152篇 |
1972年 | 192篇 |
排序方式: 共有10000条查询结果,搜索用时 140 毫秒
101.
The midwifery art has emphasised the uniqueness of human beings throughout its Nordic history. The educated Nordic midwife has in the last decade celebrated several hundred years of memories. This article studies how the key ideas of the midwifery art and patterns of ideas become evident in the zeitgeist from the beginning of the 19th century to the millennium in the Nordic countries. The legacy and pattern of ideas of the art of midwifery are interpreted in relation to the texts of the selected historical sources and based on Ricoeur's phenomenological-hermeneutic approach to the text and further to the dedication of understanding and interpretation. The historical sources refer to unprinted primary sources from historical archives and printed secondary and tertiary sources. The patterns of ideas include a tripartite whole: the true cultivation of the head, the philosophy and aesthetics of the hand, the strength of the heart and the drive of calling. These ideas open for unique visions and attest to the evident in modern midwives. Today's midwives have academic training with examinations, and the education is based on scientific evidence. The midwife profession is authorised by the state and supervised by the authorities. 相似文献
103.
PNPLA3 gene polymorphism and response to lifestyle modification in patients with nonalcoholic fatty liver disease
下载免费PDF全文
![点击此处可从《Journal of gastroenterology and hepatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
104.
Iria Montero Prez Laura Rodríguez‐Pazos Adriana lvarez‐Prez MªMercedes Pereiro Ferreirs Carlos Aliste Jose Manuel Suarez‐Pearanda Jaime Toribio 《Journal of cutaneous pathology》2015,42(11):889-893
Classical Kaposi sarcoma (KS) usually appears on lower extremities accompanied or preceded by local lymphedema. However, the development in areas of chronic lymphedema of the arms following mastectomy, mimicking a Stewart–Treves syndrome, has rarely been described. We report an 81‐year‐old woman who developed multiple, erythematous to purple tumors, located on areas of post mastectomy lymphedema. Histopathological examination evidenced several dermal nodules formed by spindle‐shaped cells that delimitated slit‐like vascular spaces with some red cell extravasation. Immunohistochemically, the human herpesvirus type 8 (HHV‐8) latent nuclear antigen‐1 was detected in the nuclei of most tumoral cells confirming the diagnosis of KS. Lymphedema could promote the development of certain tumors by altering immunocompetence. Although angiosarcoma (AS) is the most frequent neoplasia arising in the setting of chronic lymphedema, other tumors such as benign lymphangiomatous papules (BLAP) or KS can also develop in lymphedematous limbs. It is important to establish the difference between AS and KS because their prognosis and treatment are very different. Identification by immunohistochemistry of HHV‐8 is useful for the distinction between KS and AS or BLAP. 相似文献
105.
106.
107.
选取明确诊断抗中性粒细胞胞浆抗体(ANCA)相关性血管炎患者1例作为研究对象,描述病程中的临床表现、诊疗思路及相应的检查结果。患者明确诊断后,调整治疗方案最终好转出院。ANCA相关性血管炎表现多样化,临床诊疗中应时刻警惕。 相似文献
108.
Tien‐Yao Tsai Iat‐Lon Leong Ka‐Shun Cheng Lian‐Ru Shiao Tzu‐Hui Su Kar‐Lok Wong Paul Chan Yuk‐Man Leung 《Fundamental & clinical pharmacology》2019,33(1):52-62
A pathological feature in atherosclerosis is the dysfunction and death of vascular endothelial cells (EC). Oxidized low‐density lipoprotein (LDL), known to accumulate in the atherosclerotic arterial walls, impairs endothelium‐dependent relaxation and causes EC apoptosis. A major bioactive ingredient of the oxidized LDL is lysophosphatidylcholine (LPC), which at higher concentrations causes apoptosis and necrosis in various EC. There is hitherto no report on LPC‐induced cytotoxicity in brain EC. In this work, we found that LPC caused cytosolic Ca2+ overload, mitochondrial membrane potential decrease, p38 activation, caspase 3 activation and eventually apoptotic death in mouse cerebral bEND.3 EC. In contrast to reported reactive oxygen species (ROS) generation by LPC in other EC, LPC did not trigger ROS formation in bEND.3 cells. Pharmacological inhibition of p38 alleviated LPC‐inflicted cell death. We examined whether heparin could be cytoprotective: although it could not suppress LPC‐triggered Ca2+ signal, p38 activation and mitochondrial membrane potential drop, it did suppress LPC‐induced caspase 3 activation and alleviate LPC‐inflicted cytotoxicity. Our data suggest LPC apoptotic death mechanisms in bEND.3 might involve mitochondrial membrane potential decrease and p38 activation. Heparin is protective against LPC cytotoxicity and might intervene steps between mitochondrial membrane potential drop/p38 activation and caspase 3 activation. 相似文献
109.
M.‐Q. Man L. Ye L. Hu S. Jeong P. M. Elias C. Lv 《Clinical and experimental dermatology》2019,44(6):654-657
While therapeutic approaches for psoriasis are widely available, preventive regimens are lacking. We aimed to determine whether improvements in epidermal function could prevent psoriasis relapse. Two self‐controlled cohort studies were designed, enrolling two cohorts of patients with psoriasis (n = 30 and n = 60) to be treated topically with an in‐house‐prepared emollient or ATOPALM® cream applied twice daily to one forearm for 20 and 30 days, respectively, while the same sites on the contralateral arm served as the untreated control. Epidermal function on both arms was assessed prior to and at the end of the trials. Delayed relapse on the treated arm was seen in 54.5% and 71% of patients in the first and second cohort, respectively. The time of psoriatic relapse correlated with the extent of abnormalities in baseline epidermal function. These results suggest that improvements in epidermal function with topical emollients can prevent/attenuate the development of psoriasis. 相似文献
110.