全文获取类型
收费全文 | 1117篇 |
免费 | 71篇 |
国内免费 | 14篇 |
专业分类
耳鼻咽喉 | 26篇 |
儿科学 | 24篇 |
妇产科学 | 34篇 |
基础医学 | 108篇 |
口腔科学 | 29篇 |
临床医学 | 85篇 |
内科学 | 306篇 |
皮肤病学 | 14篇 |
神经病学 | 63篇 |
特种医学 | 50篇 |
外科学 | 196篇 |
综合类 | 51篇 |
预防医学 | 38篇 |
眼科学 | 28篇 |
药学 | 81篇 |
中国医学 | 2篇 |
肿瘤学 | 67篇 |
出版年
2023年 | 16篇 |
2022年 | 63篇 |
2021年 | 74篇 |
2020年 | 54篇 |
2019年 | 57篇 |
2018年 | 73篇 |
2017年 | 61篇 |
2016年 | 45篇 |
2015年 | 48篇 |
2014年 | 60篇 |
2013年 | 83篇 |
2012年 | 102篇 |
2011年 | 71篇 |
2010年 | 55篇 |
2009年 | 41篇 |
2008年 | 42篇 |
2007年 | 37篇 |
2006年 | 37篇 |
2005年 | 51篇 |
2004年 | 52篇 |
2003年 | 27篇 |
2002年 | 23篇 |
2001年 | 1篇 |
2000年 | 4篇 |
1999年 | 2篇 |
1998年 | 3篇 |
1997年 | 5篇 |
1996年 | 2篇 |
1994年 | 4篇 |
1993年 | 1篇 |
1992年 | 1篇 |
1990年 | 2篇 |
1984年 | 2篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1977年 | 1篇 |
排序方式: 共有1202条查询结果,搜索用时 0 毫秒
991.
Waleed O. Twal Sandra C. Klatt Keerthi Harikrishnan Ebtesam Gerges Marion A. Cooley Thomas C. Trusk Boran Zhou Mohamed G. Gabr Tarek Shazly Susan M. Lessner Roger R. Markwald W. Scott Argraves 《Annals of biomedical engineering》2014,42(7):1470-1481
To meet demands of vascular reconstruction, there is a need for prosthetic alternatives to natural blood vessels. Here we explored a new conduit fabrication approach. Macroporous, gelatin microcarriers laden with human umbilical vein endothelial cells and aortic smooth muscle cells were dispensed into tubular agarose molds and found to adhere to form living tubular tissues. The ability of cellularized microcarriers to adhere to one another involved cellular and extracellular matrix bridging that included the formation of epithelium-like cell layers lining the lumenal and ablumenal surfaces of the constructs and the deposition of collagen and elastin fibers. The tubular tissues behaved as elastic solids, with a uniaxial mechanical response that is qualitatively similar to that of native vascular tissues and consistent with their elastin and collagen composition. Linearized measures of the mechanical response of the fabricated tubular tissues at both low and high strains were observed to increase with duration of static culture, with no significant loss of stiffness following decellularization. The findings highlight the utility of cellularized macroporous gelatin microcarriers as self-adhering building blocks for the fabrication of living tubular structures. 相似文献
992.
A perivascular niche for brain tumor stem cells 总被引:44,自引:0,他引:44
Calabrese C Poppleton H Kocak M Hogg TL Fuller C Hamner B Oh EY Gaber MW Finklestein D Allen M Frank A Bayazitov IT Zakharenko SS Gajjar A Davidoff A Gilbertson RJ 《Cancer cell》2007,11(1):69-82
Cancers are believed to arise from cancer stem cells (CSCs), but it is not known if these cells remain dependent upon the niche microenvironments that regulate normal stem cells. We show that endothelial cells interact closely with self-renewing brain tumor cells and secrete factors that maintain these cells in a stem cell-like state. Increasing the number of endothelial cells or blood vessels in orthotopic brain tumor xenografts expanded the fraction of self-renewing cells and accelerated the initiation and growth of tumors. Conversely, depletion of blood vessels from xenografts ablated self-renewing cells from tumors and arrested tumor growth. We propose that brain CSCs are maintained within vascular niches that are important targets for therapeutic approaches. 相似文献
993.
Mohammad Kamal Mobashir Waleed M. Basha Abd ElRaof Said Mohamed Mohammed Elsayed Elmaghawry 《Auris, nasus, larynx》2018,45(2):254-260
Objective
The main goal of surgery in acquired middle ear cholesteatomas is the complete eradication of the disease with an ear free of discharge. This can be performed either by open or closed techniques with their benefits and drawbacks. We present the technique of reposition of the posterior canal wall for the management of cholesteatoma cases and its results and outcome.Patients and methods
This study included 31 patients with primary acquired middle ear cholesteatoma. The surgical technique included complete cortical mastoidectomy, wide posterior tympanotomy, dividing the bony posterior meatal wall with a micro-sagittal saw and its removal, dissection and eradication of cholesteatoma, and repositioning the canal wall segment in its anatomical site.Results
No significant intraoperative complication occurred. An injury to the dura occurred in one patient. Damage of the bony posterior canal wall occurred in two patients during saw cutting. Residual cholesteatoma was found in two patients. No dislocation or necrosis of the reconstructed posterior canal wall was noted and the new reconstructed external ear canal appeared to be of near normal size, shape, and contour.Conclusion
This technique provides optimal surgical exposure and access to areas that are difficult to reach by CWU approach, allows removal of the cholesteatoma without intraoperative complications, decreases the rate of residual cholesteatoma, restores near-normal anatomy of the external auditory canal, and avoids the sequelae of the open mastoid cavity. Therefore, it would be a feasible alternative to the standard CWU and CWD procedures. 相似文献994.
Sahar Mahfouz Abdel Galil Azzahra Mohammed Edrees Afnan Khaled Ajeeb Ghadeer Sameer Aldoobi Mohamed El-Boshy Waleed Hussain 《Platelets》2017,28(2):203-207
Hematological abnormalities, especially thrombocytopenia (TCP), are highly prevalent among patients with systemic lupus erythematosus (SLE) and at the same time it has been reported as a significant prognostic factor of SLE course. We further investigate the correlation between platelet count and the clinical manifestations and disease activity of SLE, in a cohort of Saudi Arabian female patients. A retrospective analysis was done for the medical records of 100 SLE female patients, selected from all patients diagnosed and treated for SLE at the Rheumatology outpatient clinics in Hera’a General Hospital, Holly Makkah, Saudi Arabia. The data collected from every patient’s file included laboratory investigations (complete blood count, platelet parameters, ESR, anti-double-stranded DNA antibody, ANA), clinical manifestations, as well as SLE disease activity index (SLEDAI-2k) scores throughout a period of six sequential follow-up visits. Patients were divided into three groups according to the SLEDAI-2k: mild, moderate, and high-activity group. We found that, out of 100 patients, TCP was the most prevalent hematological abnormality evident in 15%, more than leucopenia (14%) and anemia (2%). TCP was acute in onset and associated with arthritis, neurologic manifestations, and nephritis. Platelet count showed a significant negative correlation with disease activity, in all of the three groups of patients. We concluded that platelet count has a negative correlation with disease activity in SLE patients, whatever the associated manifestations, and it should be considered as a prognostic factor, identifying patients with aggressive disease course. 相似文献
995.
996.
Waleed Albishi Baraa Baltow Nora Albusayes Ameer A Sayed Hamza M Alrabai 《World journal of orthopedics》2022,13(10):876-890
Rupture of the anterior cruciate ligament (ACL) is a common orthopedic injury. Various graft options are available for the reconstruction of ruptured ACL. Using the hamstring muscle as an autograft was first described in 1934, and it remains a commonly harvested graft for ACL reconstruction. Hamstring autografts can be harvested using the traditional anteromedial approach or the newer posteromedial technique. An isolated semitendinosus tendon can be used or combined with the gracilis tendon. There are numerous methods for graft fixation, such as intra-tunnel or extra-tunnel fixation. This comprehensive review discusses the different hamstring muscle harvesting techniques and graft preparation options and fixation methods. It provides a comprehensive overview for choosing the optimal surgical technique when treating patients. 相似文献
997.
998.
999.