全文获取类型
收费全文 | 5738篇 |
免费 | 311篇 |
国内免费 | 31篇 |
专业分类
耳鼻咽喉 | 62篇 |
儿科学 | 112篇 |
妇产科学 | 27篇 |
基础医学 | 835篇 |
口腔科学 | 292篇 |
临床医学 | 317篇 |
内科学 | 1383篇 |
皮肤病学 | 155篇 |
神经病学 | 503篇 |
特种医学 | 197篇 |
外科学 | 1069篇 |
综合类 | 23篇 |
预防医学 | 146篇 |
眼科学 | 81篇 |
药学 | 283篇 |
中国医学 | 7篇 |
肿瘤学 | 588篇 |
出版年
2022年 | 40篇 |
2021年 | 87篇 |
2020年 | 44篇 |
2019年 | 59篇 |
2018年 | 100篇 |
2017年 | 86篇 |
2016年 | 106篇 |
2015年 | 101篇 |
2014年 | 136篇 |
2013年 | 164篇 |
2012年 | 210篇 |
2011年 | 244篇 |
2010年 | 167篇 |
2009年 | 140篇 |
2008年 | 227篇 |
2007年 | 261篇 |
2006年 | 264篇 |
2005年 | 255篇 |
2004年 | 258篇 |
2003年 | 240篇 |
2002年 | 245篇 |
2001年 | 244篇 |
2000年 | 237篇 |
1999年 | 204篇 |
1998年 | 75篇 |
1997年 | 37篇 |
1996年 | 44篇 |
1995年 | 44篇 |
1994年 | 32篇 |
1993年 | 42篇 |
1992年 | 133篇 |
1991年 | 117篇 |
1990年 | 119篇 |
1989年 | 127篇 |
1988年 | 99篇 |
1987年 | 105篇 |
1986年 | 98篇 |
1985年 | 89篇 |
1984年 | 83篇 |
1983年 | 69篇 |
1982年 | 34篇 |
1979年 | 73篇 |
1978年 | 40篇 |
1977年 | 34篇 |
1973年 | 38篇 |
1971年 | 32篇 |
1970年 | 36篇 |
1969年 | 39篇 |
1968年 | 37篇 |
1967年 | 42篇 |
排序方式: 共有6080条查询结果,搜索用时 15 毫秒
11.
12.
13.
N Suzuki Y Arai Y Miyamoto N Isokane N Fukushima Y Sano 《Nihon Kyōbu Shikkan Gakkai zasshi》1991,29(12):1630-1637
A 23-year-old male with bronchial asthma developed eosinophilia (eosinophils greater than 2,000/mm3) and was observed at our hospital. After using a prescribed indomethacin suppository for fever at home, he experienced an attack of acute chest pain and severe dyspnea. He suffered cardiac arrest while being transferred to the ward. After resuscitation, he was diagnosed as having acute myocardial infarction on the basis of electrocardiographic and ultrasonic cardiographic findings, and marked elevation of serum concentrations of myocardial enzymes. Thereafter, he often complained of precordial pain and abdominal pain. When he was administered an analgesic in another hospital, he developed severe precordial pain, and marked ST elevation was recorded on the electrocardiogram. Coronary angiography revealed no stenosis nor atherosclerotic changes, suggesting that severe spasm of the coronary arteries and direct myocardial injury by eosinophils were the causes of the myocardial infarction-like symptoms and angina pectoris-like attacks. He was diagnosed as having Churg-Strauss syndrome (allergic granulomatous angiitis) on the basis of the clinical findings; skin biopsy and transbronchial lung biopsy findings were consistent with the diagnosis. Following steroid administration, his angina-like attacks and abdominal pain ceased. This patient developed two episodes of acute cardiovascular symptoms upon administration of antipyretic analgesics. This suggests that in cases of Churg-Strauss syndrome with aspirin-induced asthma, physicians must be aware of the cardiovascular complications, and such drugs should be administered with caution. 相似文献
14.
A transcrista galli, translamina terminalis approach for highly placed basilar bifurcation aneurysms
Summary Surgery for highly placed basilar bifurcation aneurysms is one of the most difficult operations in neurosurgery. Specific surgical techniques have been developed including the temporopolar, zygomatic, transzygomatic subtemporal, transclinoid trans-sellar transcavernous, and trans third ventricular approaches. The authors present some technical advances which have been developed for the transcristagalli translamina terminalis approach for the treatment of this aneurysm. 相似文献
15.
Protective effects of benidipine on arachidonic acid-induced acute cerebral ischemia in rats. 总被引:1,自引:0,他引:1
Acute cerebral ischemia was produced in rats by injection of arachidonic acid (AA) into the internal carotid artery. Evans blue (EB) was intravenously injected and its extravasation into the brain was determined as an indicator of disturbances in the blood-brain barrier and endothelial cells. Control animals showed severe cerebral edema and marked blue staining of the brain. Benidipine (30 micrograms/kg, i.p.) suppressed the increase in cerebral water content and the extravasation of EB. Similarly nicardipine (100 micrograms/kg, i.p.) suppressed the elevation of water content and the extravasation of EB. Furthermore, both benidipine (30 micrograms/kg, i.p.) and nicardipine (100 micrograms/kg, i.p.) improved the neuronal injuries following AA-injection. An antiplatelet agent, ticlopidine (100 mg/kg, i.p.), and a thromboxane A2 synthetase inhibitor, OKY-1581 (3 mg/kg, i.p.), also suppressed the elevation of cerebral water content. A lipoxygenase inhibitor, AA-561 (200 mg/kg, p.o.), and a cyclooxygenase inhibitor, indomethacin (10 mg/kg, i.p.), did not prevent the increase in cerebral water content. Neither benidipine (3-30 micrograms/kg, i.v.) nor nicardipine (100 micrograms/kg, i.v.) inhibited the AgNO3-induced thrombus formation of the abdominal aorta, whereas ticlopidine (100 mg/kg, p.o.) and OKY-1581 (3 mg/kg, i.v.) prevented the thrombus formation. From the present results, it is suggested that benidipine, as well as nicardipine, may protect against AA-induced acute cerebral infarction via a mechanism independent of antithrombotic action. 相似文献
16.
17.
S Tsuneishi S Takada T Motoike T Ohashi K Sano H Nakamura 《Brain research. Developmental brain research》1991,61(1):117-123
Effects of dexamethasone (DEX) on the relative abundance of myelin basic protein (MBP), proteolipid protein (PLP) and glial fibrillary acidic protein (GFAP) mRNAs in the developing rat brain were examined. After DEX (1.0 mg/kg body weight) or saline was administered intraperitoneally to 3-day-old rats for 7 consecutive days, wet weight, DNA content and the relative abundance of the glia-specific mRNAs in cerebrum and cerebellum were analyzed at postnatal days (P) 10, 20 and 30. DEX decreased both wet weight and DNA content in cerebellum more profoundly than in cerebrum. The appearance of MBP, PLP and GFAP mRNAs in cerebellum preceded that in cerebrum in the control group. In cerebrum, the relative abundance of MBP and PLP mRNAs was significantly less in the DEX group than that in the control group at P20 and P30. The relative abundance of the GFAP mRNA was significantly less in the DEX group than in the control group at P10 and P20, but there was no significant difference at P30. In cerebellum, a significant decrease in the abundance of MBP, PLP and GFAP mRNAs in the DEX group was observed only at P10 but not at P20 and P30. Our findings indicate that DEX suppresses expression of genes related to glial functions, especially myelination when administered in the early postnatal period. 相似文献
18.
19.
To elucidate the molecular basis for endocrine tumorigenesis, p53 mutations in human endocrine tumors were analyzed by using polymerase chain reaction-single strand conformation polymorphism. Exons 5 through 10 of the p53 gene were studied in genomic DNAs from 134 primary endocrine tumors and 6 human endocrine cancer-derived cell lines. Mutations were detected and identified in 4 endocrine tumors, including one parathyroid adenoma and three thyroid carcinoma cell lines. The sites of these mutations were in exons 5 (codon 151 and 152) and 7 (codon 248 and 255). In all of three tumor cell lines, but not in a parathyroid adenoma, the normal allele encoding the p53 gene was lost. However, p53 mutations were not found in any other endocrine tumors or cell lines. Based upon these results, we concluded that the p53 gene may play a role in the tumorigenesis of a limited number of parathyroid adenoma and thyroid cancers, and that the p53 mutation with an allelic loss of the p53 gene is an important factor in malignant tumorigenesis of the thyroid gland. 相似文献
20.
Akihiro Hagiwara Masashi Sano Emiko Asakawa Hikaru Tanaka Ryohei Hasegawa Nobuyuki Ito 《Cancer science》1992,83(9):949-954
The modifying potential of two nephrotoxic agents, harman and norharman, on N-ethyl-N-hydroxyethylnitrosamine (EHEN)-induced renal and hepatic carcinogenesis was investigated in male F344/DuCrj rats. Animals were given 0.1% EHEN in their drinking water for the first 2 weeks as an initiator. Subsequently, starting 3 weeks from the commencement, they were fed diet containing these compounds at concentrations of 1000, S00 or 0 ppm until week 26, and then killed for light microscopic examination. The mean numbers of renal tubular cell hyperplasias/cm2 and those of tumors/cm2 in rats given harman and norharman at 1000 ppm after initiation, but not at 500 ppm, were significantly increased as compared to the control values. However, neither compound modified liver carcinogenesis. It is concluded that harman and norharman show enhancing effects on rat kidney carcinogenesis, when ingested at dose levels which cause renal tubular damage. 相似文献