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51.
52.
Mohamed Abdel Wahab Ahmed Shehta Mohamed Elshoubary Tarek Salah Omar Fathy Ahmed Sultan Ahmed Nabieh Elghawalby Mahmoud Ali Amr Mohamed Yassen Mohamed Elmorshedi Mohamed Eldesoky Ahmed Monier Rami Said 《Journal of gastrointestinal surgery》2018,22(12):2055-2063
Background
Portal vein thrombosis (PVT) is a common complication for patients with end-stage liver disease. The presence of PVT used to be a contraindication to living donor liver transplantation (LDLT). The aim of this study is to evaluate the influence of preoperative PVT on perioperative and long-term outcomes of the recipients after LDLT.Methods
We reviewed the data of patients who underwent LDLT during the period between 2004 till 2017.Results
During the study period, 500 cases underwent LDLT. Patients were divided into three groups. Group I included non-PVT, 446 patients (89.2%); group II included attenuated PV, 26 patients (5.2%); and group III included PVT, 28 patients (5.6%). Higher incidence of hematemesis and encephalopathy was detected in PVT (p?=?0.001). Longer anhepatic phase was found in PVT (p?=?0.013). There were no significant differences between regarding operation time, blood loss, transfusion requirements, ICU, and hospital stay. The 1-, 3-, and 5-year overall survival (OS) rates of non-PVT were 80.5%, 77.7%, and 75%, and for attenuated PV were 84.6%, 79.6%, and 73.5%, and for PVT were 88.3%, 64.4%, and 64.4%, respectively. There was no significant difference between the groups regarding OS rates (logrank 0.793).Conclusion
Preoperative PVT increases the complexity of LDLT operation, but it does not reduce the OS rates of such patients.53.
Muhammad Mustehsan Bashir Muhammad Sohail Ahmad Wahab Umar Iqbal Rehan Qayyum Saadia Nosheen Jan 《Burns : journal of the International Society for Burn Injuries》2018,44(3):678-682
Objective
To compare the clinical outcomes of release of flexion contractures after burn of the hand in children using tourniquet or tumescent technique in terms of operative time, postoperative pain score, and percentage of graft take.Methods
Patients aged 3 to 12 years who required release of post-burn flexion contractures involving volar aspect of palm and fingers were enrolled from outpatient clinic. Patients were randomized in 1:1 ratio to the use of either tumescent technique or tourniquet during contracture release. Duration of procedure, postoperative pain score, percentage of graft take, and any complications were assessed and analyzed in both groups by a blinded observer.Results
Of the 160 patients randomized in the study (80 in each group), 84 (52.5%) were males. The mean ± SD age of participants was 7.84 ± 3.49 years, with no statistically significant difference in gender and age distribution between the groups. Similarly, there was no statistically significant difference in duration of surgery in both groups. However, there was a statistically significant difference in percentage of graft take at the 14th postoperative day; significantly more graft take was noted in the tumescent group (8.97 ± 3.7 cm vs. 7.26 ± 2.6 cm; P = 0.001). Mean analgesia consumed in the tumescent group was significantly less than that of the tourniquet group (6.26 ± 1.9 mg vs. 9.41 ± 2.2 mg; P ≤ 0.001). Similarly, statistically significant difference in the mean FLACC pain score was noted, with remarkably low pain score in the tumescent group.Conclusion
We found that the use of the tumescent technique for the release of flexion contracture resulted in better graft take, lower pain scores, and lesser consumption of analgesic than the use of tourniquet. 相似文献54.
55.
V. Sharma P. M. Gaye S. A. Wahab N. Ndlovu T. Ngoma V. Vanderpuye A. Sowuhami D. A. Dawotola J. Kigula‐Mugambe B. Jeremic 《Diseases of the esophagus》2010,23(3):240-243
While numerous surveys of pattern of practices of palliative radiotherapy (RT) in advanced esophageal cancers have been published in developed countries, there is no such survey in African countries. During and after a regional training course by the International Atomic Energy Agency (IAEA) in palliative cancer care, a questionnaire was distributed to African RT centers to gather information about infrastructure and human resources available, and the pattern of practice of palliative RT for esophageal cancers. Twenty‐four of the 35 centers (60%) completed the questionnaire. Twenty out of 23 (87%) centers treat patients with esophageal cancer presenting with dysphagia using external beam RT (16 centers external beam RT alone and 4 centers also use brachytherapy as a boost). Twelve (60%) centers prescribe RT doses of 30 Gy in 10 fractions and 2 centers 20 Gy in 5 fractions. Eighteen centers (78%) have low dose rate (LDR) brachytherapy, and 9 (39%) centers have high dose rate (HDR) brachytherapy. One center only used HDR brachytherapy alone to a dose of 16 Gy in 2 fractions over 8 days. RT remains a major component of treatment of patients with esophageal cancers in African countries. Still, there is a great variety among centers in both indications for RT and its characteristics for a treatment indication. 相似文献
56.
Chua KB Mustafa B Abdul Wahab AH Chem YK Khairul AH Kumarasamy V Mariam M Nurhasmimi H Abdul Rasid K 《The Malaysian journal of pathology》2011,33(1):13-20
A prospective study was carried out to evaluate the sensitivity of dengue NS1 antigen-capture ELISA in comparison with dengue virus isolation, conventional RT-PCR and real-time RT-PCR for laboratory confirmation of acute dengue based on single-acute serum samples. Four primary healthcare centres were involved to recruit patients with clinical diagnosis of dengue illness. Patient's demographic, epidemiological and clinical information were collected on a standardized data entry form and 5 ml of venous blood was collected upon consent. In the laboratory, six types of laboratory tests were performed on each of the collected acute serum sample. Of the 558 acute serum samples collected from 558 patients with clinical diagnosis of dengue from mid-August 2006 to March 2009, 174 serum samples were tested positive by the dengue NS1 antigen-capture ELISA, 77 by virus isolation, 92 by RT-PCR and 112 by real-time RT-PCR. A total of 190 serum samples were tested positive by either one or a combination of the four methods whereas, only 59 serum samples were tested positive by all four methods. Thus, based on single-acute serum samples, 190 of the 558 patients (34.1%) were laboratory-confirmed acute dengue. The overall test sensitivity was 91.6%, 40.5%, 48.4% and 58.9% for dengue NS1 antigen-capture ELISA, virus isolation, conventional RT-PCR and real-time RT-PCR respectively. Statistically, dengue NS1 antigen-capture ELISA was the most sensitive and virus isolation was the least sensitive test for the laboratory confirmation of acute dengue based on single-acute serum specimens. Real-time RT-PCR was significantly more sensitive than the conventional RT-PCR. 相似文献
57.
58.
Coe TS Hamilton PB Griffiths AM Hodgson DJ Wahab MA Tyler CR 《Ecotoxicology (London, England)》2009,18(1):144-150
There is substantial evidence that genetic variation, at both the level of the individual and population, has a significant
effect on behaviour, fitness and response to toxicants. Using DNA microsatellites, we examined the genetic variation in samples
of several commonly used laboratory strains of zebrafish, Danio rerio, a model species in toxicological studies. We compared the genetic variation to that found in a sample of wild fish from
Bangladesh. Our findings show that the wild fish were significantly more variable than the laboratory strains for several
measures of genetic variability, including allelic richness and expected heterozygosity. This lack of variation should be
given due consideration for any study which attempts to extrapolate the results of ecotoxicological laboratory tests to wild
populations. 相似文献
59.
60.
Summary The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) is a major determinant of methylating anticancer drug resistance. Inactivation
of MGMT by pseudosubstrate inhibitors, such as O6-benzylguanine (O6BG), sensitizes tumor cells to O6-alkylating agents. However, systemic administration of O6BG causes depletion of MGMT in all tissues of the body. Therefore, dose reduction of O6-alkylating drugs administered together with O6BG is required in order to avoid unwished toxic side effects. To attenuate the increased systemic toxicity caused by MGMT
inhibitors, local MGMT inactivation would be desirable. Here, we report on intracerebral treatment with O6BG of a patient suffering from glioblastoma. O6BG was administered weekly in the tumor cavity by means of an Ommaya reservoir. This application was well tolerated. Concomitant
treatment with temozolomide (Temodal) was associated with transient tumor stabilization without detectable side effects. Although
evidence is still lacking that local O6BG administration caused MGMT to be depleted in the residual tumor, the trial shows that intracerebral treatment with O6BG is feasible. It might be a safe strategy for improving glioma therapy by treatment with temozolomide (and presumably also
other O6-alkylating drugs) concomitant with O6BG without augmenting drug-induced systemic side effects. 相似文献