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81.
Background
Previous research has shown a loss of bone mineral density (BMD) during pregnancy. This loss has been correlated to the occurrence of back pain symptoms during pregnancy. The objective of this study was to evaluate whether persistence of back pain symptoms 2 years after pregnancy could be associated with BMD changes as measured by quantitative USG of the os calcis. 相似文献82.
Duijkers IJ; Klipping C; Willemsen WN; Krone D; Schneider E; Niebch G; Hermann R 《Human reproduction (Oxford, England)》1998,13(9):2392-2398
The gonadotrophin-releasing hormone antagonist Cetrorelix is in advanced
clinical development for the control of endogenous gonadotrophin secretion
during the course of a fertility programme. The aim of the present study
was to investigate the pharmacokinetics and pharmacodynamics of Cetrorelix
following single and multiple s.c. administration of different doses.
Thirty-six healthy female volunteers received either 0.25, 0.50 or 1.00 mg
Cetrorelix, in a first menstrual cycle as single dose and in a second cycle
as multiple dose (daily between cycle days 3 and 16). Frequent blood
samples were collected for determination of Cetrorelix, follicle
stimulating hormone (FSH), luteinizing hormone (LH), oestradiol and
progesterone concentrations. Follicular growth was measured by transvaginal
ultrasonography. After single administration of each dose, maximum
Cetrorelix concentrations (Cmax) were reached after 1 h, and Cmax and area
under curve (AUC) increased linearly with the dose. The median terminal
half-life ranged from 5 to 10 h in the three different dose groups. FSH,
LH, oestradiol and progesterone concentrations were suppressed, with a
nadir at 6-12 h after Cetrorelix administration. During multiple
administration, Cmax and AUC also showed dose-linearity. The median
terminal half-life of Cetrorelix varied between 20 and 80 h. A
dose-dependent suppression of FSH, LH and oestradiol concentrations was
observed during treatment. After multiple administration, ovulation was
delayed for 5, 10 and 13 days in the 0.25, 0.50 and 1.00 mg dose groups,
respectively. In conclusion, Cetrorelix showed linear pharmacokinetics, and
effectively delayed the LH surge.
相似文献
83.
Miriam Hoekstra Mathijs Vogelzang Evgeny Verbitskiy Maarten WN Nijsten 《Critical care (London, England)》2009,13(5):223-7
Current care guidelines recommend glucose control (GC) in critically ill patients. To achieve GC, many ICUs have implemented
a (nurse-based) protocol on paper. However, such protocols are often complex, time-consuming, and can cause iatrogenic hypoglycemia.
Computerized glucose regulation protocols may improve patient safety, efficiency, and nurse compliance. Such computerized
clinical decision support systems (Cuss) use more complex logic to provide an insulin infusion rate based on previous blood
glucose levels and other parameters. A computerized CDSS for glucose control has the potential to reduce overall workload,
reduce the chance of human cognitive failure, and improve glucose control. Several computer-assisted glucose regulation programs
have been published recently. In order of increasing complexity, the three main types of algorithms used are computerized
flowcharts, Proportional-Integral-Derivative (PID), and Model Predictive Control (MPC). PID is essentially a closed-loop feedback
system, whereas MPC models the behavior of glucose and insulin in ICU patients. Although the best approach has not yet been
determined, it should be noted that PID controllers are generally thought to be more robust than MPC systems. The computerized
Cuss that are most likely to emerge are those that are fully a part of the routine workflow, use patient-specific characteristics
and apply variable sampling intervals. 相似文献
84.
The authors report an initially successful left gastric artery embolization performed because of massive upper gastrointestinal bleeding; the procedure was complicated by focal gastric and hepatic infarctions. These complications occurred in the absence of underlying factors known to predispose to ischemia. Low-grade gastric bleeding persisting after seemingly successful embolization of the left gastric artery may indicate ischemic gastritis and is an indication for endoscopy. In addition, the presence of a left hepatic artery completely replaced to the left gastric artery should alert one to the potential for hepatic necrosis. 相似文献
85.
86.
神经肽DGAVP和Org2766对神经细胞内游离Ca~(2+)的影响 总被引:1,自引:0,他引:1
运用Ca~(2+)指示剂Fura-2作为细胞内钙离子的荧光探针,利用AR—CM—MIC阳离子测定系统,检测了分离的神经细胞内游离钙及其变化,并观测了DGAVP和Org2766对蛋白质合成抑制剂茴香霉素(ANI)引起细胞内钙离子浓度([Ca~(2+)]_i)变化的影响。结果表明茴香霉素可使[Ca~(2+)]_i显著升高,且有量效关系;DGAVP本身并不引起[Ca~(2+)]_i发生显著变化,但适当剂量的DGAVP可显著对抗一定剂量范围内ANI升高[Ca~(2+)]_i的作用,提示DGAVP对抗ANI的蛋白质合成抑制效应可能是通过拮抗ANI升高[Ca~(2+)]_i这一途径实现的,另一神经肽Org2766则可能不是通过这一机制发生作用。从细胞内Ca~(2+)的角度看,这两种肽的作用机理显然是不同的。 相似文献
87.
Sisto SA; Tapp WN; LaManca JJ; Ling W; Korn LR; Nelson AJ; Natelson BH 《QJM : monthly journal of the Association of Physicians》1998,91(7):465-473
We measured physical activity after strenuous exercise in 20 women with
chronic fatigue syndrome (CFS), compared to 20 sedentary healthy volunteers
who exercised no more than once per week. Activity was measured for 2 weeks
using a portable waist-worn vertical accelerometer. After the first week of
activity monitoring, all participants returned for a maximal treadmill
test, followed by continued activity monitoring for the second week. Five
activity measures were derived from the data: (i) average activity; (ii)
total activity; (iii) duration of waking day; (iv) duration; and (v) number
of daily rests. A repeated measures ANCOVA was used to determine post-
treadmill group differences accounting for pre-treadmill differences. There
was a significant reduction in overall average activity after the treadmill
test, with the greatest decrease on days 12 through 14. This reduction was
accompanied by a significant increase in the duration of the waking day and
number of daily rests. Thus, marked exertion does produce changes in
activity, but later than self-report would suggest, and are apparently not
so severe that CFS patients cannot compensate.
相似文献
88.
设计合成了21个1-[2-(取代苯基甲硫基)-2-(2,4-二氟苯基)乙基]-1H-1,2,4-三唑类化合物,其中19个为首次报道。体外抑菌试验表明:所有目标化合物对8种试验真菌均有不同程度的抗菌活性,其中化合物1,2,5对絮状表皮癣菌的活性为硫康唑的512倍以上;化合物5对白色念株菌的活性为硫康唑的32倍;化合物2对申克孢子丝菌的活性为硫康唑的32倍;化合物2,14对新型隐球菌的活性分别为硫康唑的64倍,32倍;化合物1,5对熏烟色曲菌的活性分别为硫康唑的16倍以上。 相似文献
89.
90.
The unprotected parasphenoidal carotid artery studied by high- resolution computed tomography 总被引:1,自引:0,他引:1
A retrospective review was made of 500 consecutive thin-section axial CT scans of the adult sphenoid sinus using contrast enhancement and the bone algorithm to determine whether there was exposure of the cavernous sinus and the carotid arteries along their parasphenoidal course. At least one cavernous-carotid complex that could be considered at risk during sphenoid sinus surgery was seen in 31.4% of the patients. Of this group, 14.4% of the patients had no bony covering on one or both sides at some point along the parasphenoidal course. In 17% the bony covering was so thin it would give minimal, if any, protection from surgical trauma. A patient who had laceration of an unprotected carotid artery with development of post-traumatic aneurysm is discussed. 相似文献