构建招收飞行员基本认知能力预测学业成绩的模型

目的：通过空军招收飞行员心理品质检测第一平台的基本认知能力测验,建立学生学业成绩的预测模型,提前淘汰高考成绩不良的学生,以节省开支. 方法：①实验1：采用完全随机设计的方法,于2005-12选取西安市某部队院校入校3个月的854名大学生,进行加法计算、比较刻度、找特殊图形、组合图形、填写数据、识符检数、判别方向、选词配对、找规律填数等9项基本能力测试,利用Pearson相关分析,选出与学业成绩显著相关的4项测验.②实验2：2006-12选取与实验1不同部队院校的2006级入校3个月的200名大学生,进行4项选定的测验,通过SPSS 12.0统计软件包进行多元回归分析最终建立预测学业成绩的基本认知能力模型,并分析其预测效度. 结果：①实验1结果：选定的4项能力测试与学业成绩的相关分别是：加法计算X1（r=0.233）、找特殊图形X2（r=0.226）、填写数据X3（r=0.100）、选词配对X4（r=0.176）.②实验2结果：最终建立的预测方程是Y=532.75＋1.001X1＋1.247X3＋1.257X4,它能解释学业成绩中13.0%的变异. 结论：基本认知能力测验能预测学业成绩,并且能达到较好的效度,可以应用到飞行员选拔的实际中.     

Increased height in diabetes mellitus corresponds to the predicted and the adult height

This study was conducted to analyse the effect of childhood-onset diabetes mellitus on adult height. The height at time of diagnosis of 35 children with insulin-dependent diabetes mellitus (IDDM) was compared with growth reference data. Predictions of the adult height were made at the time of diagnosis using the target height and the Tanner-Whitehouse II method. The adult height was compared with both the predicted values and the height of healthy adults. The height at time of diagnosis of the prepubertal children was increased compared with growth reference data, in contrast to pubertal children who had normal heights. Only the prepubertal boys were taller at time of diagnosis. The adult height of the prepubertal patients was taller than growth reference data. The mean adult height in all patients did not differ significantly from the predicted heights. In conclusion, the increased height at the start of IDDM in prepubertal children persists until adulthood.     

Detection of three types of hepatitis C virus in blood donors: investigation of type-specific differences in serologic reactivity and rate of alanine aminotransferase abnormalities

The serologic reactivity and epidemiology associated with different hepatitis C virus (HCV) variants were investigated in a cohort of 113 anti-HCV-positive donors. In Scotland, HCV type 1 accounted for one- half of all infections; 40 percent of subjects were infected with HCV type 3, and the remainder were infected with type 2. Reactivity with the NS-4-encoded antigens in the first-generation anti-c100 assay was absent in 68 percent of donors infected with types 2 and 3, as compared with 10 percent for those infected with type 1. Even when combined with surrogate marker testing, first-generation tests would have failed to detect 12 percent of HCV-infected blood donors. The age distribution, incidence of past infection with hepatitis B virus, and reported risk factors were similar in donors infected with types 1 and 3 (mean ages were 31.9 and 29.9; 18 and 17.5% were positive for antibody to hepatitis B core antigen; and 47 and 48% had past intravenous drug abuse). However, the distributions of alanine aminotransferase levels were significantly different in those infected with type 3 (abnormally raised in 83%) and those infected with type 1 (55% abnormal alanine aminotransferase; p < 0.05) or type 2 (60%; p < 0.01) and those who were nonviremic (8%; p < 0.0001). These data suggest that HCV type 1 is the most common HCV infection in blood donors and that infection with HCV type 3 may be associated with more severe liver disease, because of more recent infection or because of a greater inherent pathogenicity of type 3 variants.     

Plasma exchange does not improve survival in a canine model of human septic shock

Whether plasma exchange would improve survival in antibiotic-treated canines with septic shock was investigated. Escherichia coli O86H8 (1.4 × 10(10)) was surgically implanted as an intraperitoneal clot in 18 two- year-old (10-12 kg) purpose-bred beagles. Beginning 4 hours after surgery, all animals received cefoxitin and gentamicin for 5 days. Three treatment groups were defined: 1) a no apheresis, or control group, (n = 6); 2) a sham apheresis group, whose whole blood plasma was removed, separated, and then transfused (n = 6); and 3) a plasma exchange group from whom blood and plasma were removed and separated, to whom the blood was returned, and in whom infected plasma was replaced with compatible fresh-frozen canine plasma (n = 6). For the sham apheresis and plasma exchange groups, a commercial blood cell processor was used to separate 1.5 blood volumes of plasma at 5 and 24 hours after surgery. Serial radionuclide left ventricular ejection fractions and femoral and pulmonary arterial catheter hemodynamics were measured simultaneously in awake animals. All six animals in the plasma exchange group died. In both the sham and control groups, only one of six animals survived. Survival times were ordered (median in hours) (control [372 h] > sham apheresis [48 h] > plasma exchange [24 h] [p < 0.038]). Decreases in mean cardiac index and mean arterial pressure (from before apheresis to after) at 5 to 7 hours after surgery were ordered (plasma exchange > sham apheresis > control; p < 0.03). Thus, plasma exchange in this controlled trial of septic shock was associated with decreased survival and worsened hemodynamics.(ABSTRACT TRUNCATED AT 250 WORDS)     

马缨丹根的化学成分研究

从马缨丹(Lantana camara L.)根的乙醇提取物中分离鉴定出六个寡糖(Ⅰ～Ⅵ)和六个环稀醚萜葡萄糖甙(Ⅶ～Ⅻ),即水苏糖(Ⅰ),毛蕊花糖(Ⅱ),筋骨草糖(Ⅲ),毛蕊花四糖(Ⅳ),α-D-半乳糖-(1[→6-)α-D-半乳糖-(1]₃→6-)D-葡萄糖(Ⅴ),α-D-半乳糖-(1[→6-)α-D-半乳糖-(1]₄→6-)D-葡萄糖(Ⅵ),黄夹子苦甙(Ⅶ),8-表马钱素(Ⅷ),山栀子甙甲酯(Ⅸ),黄夹苦甙(Ⅹ),lamiridoside(Ⅺ)和京尼平甙(Ⅻ)。Ⅴ和Ⅵ是新化合物,分别命名为马缨丹糖A(lantanose A)和马缨丹糖B(lantanose B),其余均首次从该植物中分离得到。     

维甲酸与二甲基亚砜诱导HL-60细胞及其抗性亚型MDR 1的表达和对Rhodamine-123外排的影响

利用Dot blot 和流式细胞术，研究了分化诱导剂维甲酸，DMSO对HL-60细胞及其抗性亚型抗药性程度的影响，表明1μmol·ml^-1 RA 作用H-60及其亚型24h， MDR 1 mRNA 明显增高，但流式检测多药抗性细胞系对Rho-123的外排有所下降。2%DMSO作用HL-60及其亚型 24h，流式细胞术检测显示各细胞系对Rho-123 的外排明显增强，提示RA 虽然提高MDR 1基因的表达，但可能通过磷酸化/脱磷酸化方式抑制Pgp-170功能的表达，而DMSO能诱导完整功能的Pgp表达。