Core-periphery differences in children's health and use of general practitioner services in Finland from 1964 to 1987.

Finland is a modern welfare state in Northern Europe especially proud of its development of programs for children's health. The aim of this study was to investigate the development of core-periphery differences in children's health and use of health services. The study material was obtained from the national health and social security interview survey carried out in 1964, 1968, 1976 and 1987. Age standardized prevalence of chronic diseases, number of restricted-activity days and physician contacts were presented for two age groups: 0-6-year-olds and 7-14-year-olds. The prevalence of chronic diseases was quite similar in the core and periphery in 1976 and 1987, but the number of restricted-activity days throughout the study period (1964-1987) was significantly higher in the core than in the periphery. The consistently higher frequency of physician contacts in the core in comparison with the periphery was spectacular; the welfare policy of the last decades seems to have had very little or no effect on this difference. The core-periphery division thus continues to have relevance with respect to the health of Finnish children.     

Burden of influenza in children in the community

BACKGROUND: Influenza vaccination of healthy children is encouraged because children are frequently hospitalized for influenza-attributable illnesses. However, most children with influenza are treated as outpatients, and scarce data are available on the burden of influenza in these children. METHODS: We performed a prospective study of respiratory infections in preenrolled cohorts of children < or = 13 years old during 2 consecutive respiratory seasons (2231 child-seasons of follow-up). At any sign of respiratory infection, we examined the children and obtained a nasal swab for the detection of influenza. The parents filled out daily symptom diaries. Of all the enrollees, 94% remained active participants in the study. RESULTS: The average annual rate of influenza was highest (179 cases/1000 children) among children < 3 years old. Acute otitis media developed as a complication of influenza in 39.7% of children < 3 years old. For every 100 influenza-infected children < 3 years old, there were 195 days of parental work loss (mean duration, 3.2 days). CONCLUSIONS: Influenza causes a substantial burden of illness on outpatient children and their families. Vaccination of children < 3 years old might be beneficial for reducing the direct and indirect costs of influenza in children.     

Neural correlates of letter-string length and lexicality during reading in a regular orthography

Behavioral studies have shown that short letter strings are read faster than long letter-strings and words are read faster than nonwords. Here, we describe the dynamics of letter-string length and lexicality effects at the cortical level, using magnetoencephalography, during a reading task in Finnish with long (eight-letter) and short (four-letter) word/nonword stimuli. Length effects were observed in two spatially and temporally distinct cortical activations: (1) in the occipital cortex at about 100 msec by the strength of activation, regardless of the lexical status of the stimuli, and (2) in the left superior temporal cortex between 200 and 600 msec by the duration of activation, with words showing a smaller effect than nonwords. A significant lexicality effect was also evident in this later activation, with stronger activation and longer duration for nonwords than words. There seem to be no distinct cortical areas for reading words and nonwords. The early length effect is likely to be due to the low-level visual analysis common to all stimulus letter-strings. The later lexicality and length effects apparently reflect converging lexico-semantic and phonological influences, and are discussed in terms of dual-route and single-route connectionist models of reading.     

Fertilization and embryonic development of whitefish (Coregonus lavaretus lavaretus) in acidic low-ionic-strength water with aluminum

The fertilization rate and extent of the cortical reaction of anadromous whitefish decreased with increasing acidity (0.034 mmol Ca(2+)L(-1)); at pH 4.5 the fertilization rate was 46% of that at pH 6.5. Aluminum (250 microg L(-1)) decreased the percentage fertilization independently of pH and reduced the cortical reaction magnitude at all pH levels. In eggs at pH 5.0, especially at pH 4.5, and in solutions with Al, the growth of embryos was impaired by a perivitelline space that was too narrow. The proportion of embryos with a curved tail tip and those with blood circulation failure increased with decreasing pH. No fry hatched at pH 4.5 and those few that hatched at pH 5.0 did not survive. No fry survived Al-containing water at pH 5.5 and survival was decreased at pH 6.5 with Al. It is concluded that for successful recruitment of anadromous whitefish, pH should preferably remain >5.5 in dilute soft water when toxic concentrations of Al are present.     

8-bromo-cGMP improves energy state in hypoxic rat atria

8-bromo-cGMP (1 X 10(-4) M) was found to prevent the hypoxia-induced decrease in creatine phosphate (CrP) and ATP in isolated rat atria. An increase in ADP was also seen after 8-bromo-cGMP treatment, while the AMP level remained unchanged. 8-bromo-cGMP administration resulted in a higher energy charge during the initial state of hypoxia. 8-bromo-cGMP did not affect heart rate or contractility during hypoxia. These results suggest that cGMP improves the energy state of the heart cell in hypoxia. The exact mechanism(s) of these effects is not known but an improvement of oxidative phosphorylation might, quantitatively, account for the changes.     

No efficacy of prednisolone in acute wheezing associated with human bocavirus infection

The efficacy of prednisolone in acute wheezing associated with human bocavirus infection was investigated in 232 hospitalized children (median age, 1.6 years). Clinical history, atopy status, and viral etiology were carefully studied. Outcomes included hospitalization time, duration of symptoms, and occurrence of relapses. No efficacy of prednisolone was found in children with serologically confirmed acute human bocavirus infection.