全文获取类型
收费全文 | 162篇 |
免费 | 5篇 |
专业分类
妇产科学 | 4篇 |
基础医学 | 26篇 |
口腔科学 | 4篇 |
临床医学 | 18篇 |
内科学 | 36篇 |
皮肤病学 | 2篇 |
神经病学 | 13篇 |
特种医学 | 11篇 |
外科学 | 21篇 |
综合类 | 1篇 |
预防医学 | 7篇 |
药学 | 11篇 |
肿瘤学 | 13篇 |
出版年
2024年 | 1篇 |
2023年 | 1篇 |
2022年 | 5篇 |
2021年 | 6篇 |
2019年 | 5篇 |
2018年 | 7篇 |
2017年 | 4篇 |
2016年 | 2篇 |
2015年 | 10篇 |
2014年 | 8篇 |
2013年 | 9篇 |
2012年 | 19篇 |
2011年 | 19篇 |
2010年 | 9篇 |
2009年 | 5篇 |
2008年 | 4篇 |
2007年 | 7篇 |
2006年 | 4篇 |
2005年 | 5篇 |
2004年 | 6篇 |
2003年 | 3篇 |
2002年 | 7篇 |
2001年 | 2篇 |
2000年 | 7篇 |
1999年 | 1篇 |
1998年 | 3篇 |
1995年 | 1篇 |
1993年 | 1篇 |
1989年 | 1篇 |
1985年 | 1篇 |
1983年 | 1篇 |
1965年 | 3篇 |
排序方式: 共有167条查询结果,搜索用时 15 毫秒
161.
We examined the effects of jump training with negative (-30% of the subject's body weight (BW)) VS. positive loading (+30% BW) on the mechanical behaviour of leg extensor muscles. 32 men were divided into control (CG), negative loading (NLG), or positive loading training group (PLG). Both training groups performed maximal effort countermovement jumps (CMJ) over a 7-week training period. The impact of training on the mechanical behaviour of leg extensor muscles was assessed through CMJ performed with external loads ranging from -30% BW to +30% BW. Both training groups showed significant ( P≤0.013) increase in BW CMJ height (NLG: 9%, effect size (ES)=0.85, VS. PLG: 3.4%, ES=0.31), peak jumping velocity ( V(peak); NLG: 4.1%; ES=0.80, P=0.011, VS. PLG: 1.4%, ES=0.24; P=0.017), and depth of the countermovement (Δ H(ecc); NLG: 20%; ES=-1.64, P=0.004, VS. PLG: 11.4%; ES=-0.86, P=0.015). Although the increase in both the V(peak) and Δ H(ecc) were expected to reduce the recorded ground reaction force, the indices of force- and power-production characteristics of CMJ remained unchanged. Finally, NLG (but not PLG) suggested load-specific improvement in the movement kinematic and kinetic patterns. Overall, the observed results revealed a rather novel finding regarding the effectiveness of negative loading in enhancing CMJ performance which could be of potential importance for further development of routine training protocols. Although the involved biomechanical and neuromuscular mechanisms need further exploration, the improved performance could be partly based on an altered jumping pattern that utilizes an enhanced ability of leg extensors to provide kinetic and power output during the concentric jump phase. 相似文献
162.
163.
164.
Yrlid U Cerovic V Milling S Jenkins CD Klavinskis LS MacPherson GG 《European journal of immunology》2006,36(10):2639-2648
The intestinal innate immune system continually interacts with commensal bacteria, thus oral vaccines should induce extra/alternative activation of DC, potentially through TLR. To examine this we collected intestinal lymph DC (iL-DC) under steady-state conditions and after feeding resiquimod (R-848), a synthetic TLR7/8 ligand, which we showed induces complete emptying of gut DC into lymph. iL-DC are heterogeneous with subset-specific functions. In this study we determined the kinetics of iL-DC subset release, activation and cytokine secretion induced by R-848. We show that L-DC comprise three distinct subsets (CD172ahigh, CD172aint and CD172alow) present with similar frequencies in intestinal but not hepatic lymph. No iL-DC express TLR7 mRNA, and only CD172a+ iL-DC express TLR8. However, after oral R-848 administration, output of all three subsets increases dramatically. CD172ahigh DC release precedes that of CD172alow DC, and the increased frequency of CD25high iL-DC is restricted to the two CD172a+ subsets. After feeding R-848 only CD172ahigh iL-DC secrete IL-6 and IL-12p40. However, CD172aint and CD172ahigh DC secrete similar but markedly lower amounts when stimulated in vitro. These results highlight the importance of in vivo approaches to assess adjuvant effects on DC and give novel insights into the subset-specific effects of an oral TLR ligand on intestinal DC. 相似文献
165.
双胍类降糖药物的历史
二甲双胍、苯乙双胍和丁双胍是植物山羊豆提取物(又叫法国紫丁花、山羊豆),起初用于治疗高血糖和2型糖尿病.将法国紫丁花当茶饮可追溯到古埃及和中世纪的欧洲,可起到缓解多尿和口臭(呼气中有甜味)的作用,而多尿和口臭均是现在大家熟悉的糖尿病症状.20世纪20年代的研究发现,双胍类是法国紫丁花中的活性物质,并进而在20世纪50年代开发用于治疗糖尿病. 相似文献
166.
Vuk Djulejić Slobodan Marinković Aleksandar Maliković Igor Jovanović Drago Djordjević Mila Ćetković Vera Todorović Milan Milisavljević 《Journal of clinical neuroscience》2012,19(10):1416-1421
The lenticulostriate arteries (LSA) and their microanatomy, region of supply and atherosclerosis were examined in 24 microdissected brains, arterial casts, and histological specimens. The LSA ranged from 2 to 12 in number and from 0.10 mm to 1.28 mm in diameter. They always arose from the initial segment of the middle cerebral artery (MCA), often from the MCA leptomeningeal branches (38.24%), and rarely from the insular segment (2.94%). They always originated as individual branches, often (61.76%) with their own common stems. In two hemispheres we found that the LSA supplied either a larger or a smaller portion of the basal ganglia and internal capsule than usual. The number of twigs to the innominate substance (substantia innominata) (3–11), and their diameters (0.07–0.30 mm), has been described for the first time, to our knowledge. Microatheromas were found in two LSA. Data about the LSA microanatomy and territory could form the basis of safer neurosurgery, more accurate neuroimaging evaluation, and precise neurological diagnosis in patients with focal ischemic lesions in the basal ganglia and internal capsule. 相似文献
167.
Bascarevic Vladimir Vukasinovic Ivan Nedeljkovic Zarko Nedeljkovic Aleksandra Milicevic Mihailo Jovanovic Nemanja Milic Marina Stanimirovic Aleksandar Scepanovic Vuk Grujicic Danica 《Radiology Case Reports》2022,17(9):3312
Carotid-cavernous fistulas (CCF) are vascular malformations characterized by an aberrant shunt between one or more sources of arterial inflow and the cavernous sinus (CS). They are subdivided into direct and indirect fistulas. This last one, called dural CCF involve dural fistulous connections between branches of the internal carotid artery or the external carotid artery. When conventional routes are not eligible, surgical exposure of the vein is the only access to the fistula. We present the case of a patient successfully treated for right sided dural CCF, by a hybrid approach. Furthermore, through a literature review, we analyze the possible risks and benefits associated with this approach. 相似文献