全文获取类型
收费全文 | 925篇 |
免费 | 69篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 57篇 |
妇产科学 | 8篇 |
基础医学 | 87篇 |
口腔科学 | 29篇 |
临床医学 | 162篇 |
内科学 | 204篇 |
皮肤病学 | 13篇 |
神经病学 | 26篇 |
特种医学 | 241篇 |
外科学 | 47篇 |
综合类 | 21篇 |
预防医学 | 30篇 |
眼科学 | 7篇 |
药学 | 34篇 |
中国医学 | 5篇 |
肿瘤学 | 27篇 |
出版年
2024年 | 3篇 |
2023年 | 8篇 |
2022年 | 2篇 |
2021年 | 9篇 |
2020年 | 6篇 |
2019年 | 6篇 |
2018年 | 22篇 |
2017年 | 11篇 |
2016年 | 18篇 |
2015年 | 20篇 |
2014年 | 26篇 |
2013年 | 24篇 |
2012年 | 15篇 |
2011年 | 16篇 |
2010年 | 35篇 |
2009年 | 55篇 |
2008年 | 25篇 |
2007年 | 8篇 |
2006年 | 13篇 |
2005年 | 4篇 |
2004年 | 6篇 |
2003年 | 14篇 |
2002年 | 11篇 |
2001年 | 13篇 |
2000年 | 9篇 |
1999年 | 12篇 |
1998年 | 49篇 |
1997年 | 52篇 |
1996年 | 64篇 |
1995年 | 48篇 |
1994年 | 43篇 |
1993年 | 47篇 |
1992年 | 17篇 |
1991年 | 9篇 |
1990年 | 15篇 |
1989年 | 35篇 |
1988年 | 30篇 |
1987年 | 33篇 |
1986年 | 33篇 |
1985年 | 23篇 |
1984年 | 15篇 |
1983年 | 10篇 |
1982年 | 22篇 |
1981年 | 14篇 |
1980年 | 8篇 |
1979年 | 2篇 |
1978年 | 4篇 |
1977年 | 12篇 |
1976年 | 11篇 |
1975年 | 13篇 |
排序方式: 共有1001条查询结果,搜索用时 0 毫秒
61.
62.
63.
64.
WANG Lei GUO Ji-feng ME Li-luo ZHANG Hai-nan SHEN Lu JIANG Hong PAN Qian XIA Kun TANG Bei-sha YAN Xin-xiang 《中华医学杂志(英文版)》2009,122(24):3082-3085
Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by a selective loss of nigrostriatal dopaminergic neurons. Clinical manifestations of this complex disease include resting tremor, bradykinesia, postural instability, gait difficulty and rigidity. Approximately 5%-10% of patients have genetic factors, yet etiology of PD remains unclear. Genetic deficits, environmental exposure, oxidative stress, mitochondrial dysfunction, 相似文献
65.
借鉴军队院校管理模式 推行量化考评规范实习生管理 总被引:1,自引:0,他引:1
本文通过对当前军队医院实习生管理现状的分析,探讨了军队院校管理模式、量化考评在医院实习生管理中的作用,提出了一些具体的工作方法和措施。 相似文献
66.
67.
Rui Wang ME Shiyu Yan ME Xue Ma ME Jinfeng Zhao ME Yuqing Han ME Yao Pan PhD Hua Zhao PhD 《Journal of Cosmetic Dermatology》2023,22(12):3427-3435
Background
The semiactive or inactive probiotics or their extracts used in dermatology have interesting properties to ameliorate signs of irritated skin and enhance the skin barrier. Bifidobacterium, as the most common probiotics, which has been found to be effective in reducing acne and improving the skin barrier function of atopic dermatitis. Bifida Ferment Lysate (BFL) can be obtained from Bifidobacterium by fermentation and extraction.Purpose
In this study, we investigated the effect of a topically used BFL on the skin using in vitro evaluation methods.Results
The results showed that upregulation of skin physical barrier gene (FLG, LOR, IVL, TGM1, and AQP3) and antimicrobial peptide gene (CAMP and hBD-2) in HaCaT cells by BFL might be responsible for skin barrier resistance. In addition, BFL had strong antioxidant properties representing a dose-dependent increasing of the scavenging capacity of DPPH, ABTS, hydroxyl, and superoxide radicals. BFL treatment also fundamentally inhibited the intracellular ROS and MDA production and improved the activities of antioxidant enzymes (CAT and GSH-Px) in H2O2-stimulated HaCaT cells. As a good immunomodulatory factor, BFL efficiently decreased the secretion of IL-8 and TNF-α cytokines, and COX-2 mRNA expression in LPS-induced THP-1 macrophages.Conclusion
BFL can strengthen the skin barrier function and stimulate skin barrier resistance, to reinforce the skin against oxidative stress and inflammatory stimuli. 相似文献68.
Screening of candidate biomaterials for alveolar augmentation using a critical‐size rat calvaria defect model 下载免费PDF全文
69.
Suk Yun Kang MD PhD Toshiaki Wasaka PhD Ejaz A. Shamim MD Sungyoung Auh PhD Yoshino Ueki MD PhD Grisel J. Lopez MD Tetsuo Kida PhD Seung‐Hyun Jin PhD Nguyet Dang ME Mark Hallett MD 《Movement disorders》2010,25(13):2148-2155
The sequence effect (SE) in Parkinson's disease (PD) is progressive slowing of sequential movements. It is a feature of bradykinesia, but is separate from a general slowness without deterioration over time. It is commonly seen in PD, but its physiology is unclear. We measured general slowness and the SE separately with a computer‐based, modified Purdue pegboard in 11 patients with advanced PD. We conducted a placebo‐controlled, four‐way crossover study to learn whether levodopa and repetitive transcranial magnetic stimulation (rTMS) could improve general slowness or the SE. We also examined the correlation between the SE and clinical fatigue. Levodopa alone and rTMS alone improved general slowness, but rTMS showed no additive effect on levodopa. Levodopa alone, rTMS alone, and their combination did not alleviate the SE. There was no correlation between the SE and fatigue. This study suggests that dopaminergic dysfunction and abnormal motor cortex excitability are not the relevant mechanisms for the SE. Additionally, the SE is not a component of clinical fatigue. Further work is needed to establish the physiology and clinical relevance of the SE. © 2010 Movement Disorder Society. 相似文献
70.