Reactions of neurons of the reticular and ventral anterior thalamic nuclei to electrical stimulation of the centrum medianum of the thalamus

Responses of 145 reticular (R) and 158 ventral anterior (VA) thalamic neurons to electrical stimulation of centrum medianum (CM) were studied in cats anaesthetized with thiopental sodium (30-40 mg/kg intraperitoneally) and immobilized with d-tubocurarine (1 mg/kg). 4.1% of R and 4.4% of VA neurons under study responded to CM stimulation by antidromic spike (latency 0.3-2.0 ms). The conduction velocity of antidromic excitation in axons of those neurons was found to be 1.7-7.6 m/s. There were neurons which responded by antidromic spike to the other thalamic nuclei stimulation as well as to CM. This fact is the electrophysiological proof of the axonal branching in these neurons. 53.8% of R and 46.9% of VA neurons responded to CM stimulation with orthodromic excitation. Two groups of cells were separated among neurons excited orthodromically. The first group neurons responded to CM stimulation by discharges composed of 6-12 spikes with frequency of 130-640 per second. The neurons of the second group generated a single spike. Inhibitory reactions were noticed only in 0.7% of R and in 4.4% of VA neurons. It is shown that afferent impulses from relay nuclei, lateral posterior nucleus and motor cortex converged to some R and VA neurons responding to CM.     

Substantiation of indication to performance of diagnostic thoracoscopy and thoracotomy in patients with pleuropulmonary diseases using method of oncological testing]

New approach for decision making concerning conduction of surgical treatment of the patients with pleuropulmonary diseases is proposed. This approach especially important in differential diagnosis of dissemination of obscure etiology. He is based on usage of a new screening diagnostic method "Oncotest", which intends setting of photohistochemical reaction in the blood smears, sections and serum for detection of biomolecular markers of cancer. Results of oncotesting of 172 patients with various pleuropulmonary diseases are analyzed. Application of a new approach permits to administer to the patient surgical or endoscopic intervention timely.