全文获取类型
收费全文 | 3369篇 |
免费 | 173篇 |
国内免费 | 26篇 |
专业分类
耳鼻咽喉 | 53篇 |
儿科学 | 42篇 |
妇产科学 | 63篇 |
基础医学 | 329篇 |
口腔科学 | 111篇 |
临床医学 | 275篇 |
内科学 | 840篇 |
皮肤病学 | 45篇 |
神经病学 | 348篇 |
特种医学 | 129篇 |
外科学 | 474篇 |
综合类 | 7篇 |
一般理论 | 2篇 |
预防医学 | 140篇 |
眼科学 | 54篇 |
药学 | 236篇 |
中国医学 | 3篇 |
肿瘤学 | 417篇 |
出版年
2023年 | 29篇 |
2022年 | 52篇 |
2021年 | 101篇 |
2020年 | 70篇 |
2019年 | 74篇 |
2018年 | 69篇 |
2017年 | 68篇 |
2016年 | 86篇 |
2015年 | 97篇 |
2014年 | 99篇 |
2013年 | 156篇 |
2012年 | 230篇 |
2011年 | 227篇 |
2010年 | 129篇 |
2009年 | 118篇 |
2008年 | 206篇 |
2007年 | 231篇 |
2006年 | 219篇 |
2005年 | 236篇 |
2004年 | 235篇 |
2003年 | 221篇 |
2002年 | 175篇 |
2001年 | 44篇 |
2000年 | 21篇 |
1999年 | 20篇 |
1998年 | 25篇 |
1997年 | 14篇 |
1996年 | 20篇 |
1995年 | 24篇 |
1994年 | 30篇 |
1993年 | 13篇 |
1992年 | 16篇 |
1991年 | 9篇 |
1990年 | 10篇 |
1989年 | 18篇 |
1988年 | 13篇 |
1987年 | 13篇 |
1986年 | 11篇 |
1985年 | 11篇 |
1984年 | 15篇 |
1983年 | 6篇 |
1982年 | 13篇 |
1981年 | 13篇 |
1980年 | 12篇 |
1979年 | 8篇 |
1978年 | 4篇 |
1975年 | 5篇 |
1974年 | 5篇 |
1973年 | 6篇 |
1972年 | 4篇 |
排序方式: 共有3568条查询结果,搜索用时 10 毫秒
51.
Lorenzo Azzi Michele Cerati Maurizio Lombardo Maria Pellilli Fabio Croveri Vittorio Maurino Angelo Tagliabue Lucia Tettamanti Malgorzata Olszewska 《Oral diseases》2019,25(6):1465-1491
Chronic ulcerative stomatitis (CUS) is an immune‐mediated disorder characterized by oral erosions and ulcers usually refractory to conventional treatments. The disease often involves middle‐aged and older women with painful lesions sometimes resembling those of erosive oral lichen planus (OLP). The most affected sites are the buccal mucosa, the gingiva and the tongue, but the skin is involved in 22.5% of cases. Histopathologic features in CUS are non‐specific and indistinguishable from those of OLP, with the exception of the presence of a mixed infiltrate composed of lymphocytes and plasma cells. Direct immunofluorescence (DIF) analysis reveals the presence of stratified epithelium‐specific antinuclear antibodies (SES‐ANA) in the lower third of the epithelium. The IgG antibodies detected on DIF are directed against the ?Np63α isoform of p63 expressed in the nuclei of the epithelial basal cells. A distinguishing feature of CUS is the low response to conventional corticosteroid therapy and the good outcome with hydroxychloroquine at the dosage of 200 mg/day or higher dosages. This paper presents a comprehensive review of CUS and is accompanied by a new case report (the 73rd case) and a proposal for updated diagnostic criteria. 相似文献
52.
53.
54.
This case report describes the possibility to use a modified rapid palatal expander like anchorage to reposition an included maxillary cuspid. Moreover it is enphasized the use of an ultrasonic device during surgery to expose the impacted tooth. 相似文献
55.
56.
57.
Alberto Facchini Sandra Magnoni Vittorio Civelli Fabio Triulzi Mario Nosotti Nino Stocchetti 《Neurocritical care》2013,19(3):376-380
Introduction
Posterior reversible encephalopathy syndrome (PRES) is a largely reversible disease with long-term favorable outcome. A minority of patients, however, may develop progressive cerebral edema and ischemia resulting in severe disability or death. We report a case of severe intracranial hypertension associated with PRES that was successfully treated according to intracranial pressure (ICP)- and cerebral perfusion pressure (CPP)-driven therapy.Methods
Case report.Results
A 42-year-old woman underwent bilateral lung transplantation for severe bronchiectasis. Her immunosuppressive regimen consisted of azathioprine, prednisone, and tacrolimus. She acutely developed an aggressive form of PRES that rapidly resulted in severe refractory intracranial hypertension despite discontinuation of potentially causative medications and adequate supportive therapy. Accordingly, second-tier therapies, including barbiturate infusion, were instituted and immunosuppression was switched to anti-thymocyte globulin followed by mycophenolate mofetil. Within 10 h of barbiturate administration, ICP dropped to 20 mmHg. Thiopental was administered for two days and then rapidly tapered because of severe urosepsis. Six months after discharge from the intensive care unit the patient returned to near-normal life, her only complaint being short-term amnesia.Conclusions
The decision to undertake ICP monitoring in medical conditions in which no clear recommendations exist greatly relies on physicians’ judgment. This case suggests that ICP monitoring may be considered in the setting of acute PRES among selected patients, when severe intracranial hypertension is suspected, provided that a multidisciplinary team of neurocritical care specialists is readily available. 相似文献58.
Vittorio Crespi Massimiliano Braga Sandro Beretta Antonio Carolei Angelo Bignamini Simona Sacco 《Neurological sciences》2013,34(7):1083-1086
It is generally assumed that minor stroke (MS) is an ischemic stroke with a short-term, good functional outcome. However, no clear definition of MS exists. Modified Rankin Scale (mRS) and National Institute of Health Stroke Scale (NIHSS) are still the most accredited standards, but scores and timing of the assessment are not homogeneous. As suggested by a qualified sample of Italian neurologists, the index parameter chosen in our analysis was mRS at the time of hospital discharge. The database of the SIRIO study (a large observational study of 2,573 patients with stroke admitted in Italian hospitals in 2005) was used to identify an mRS threshold to define MS. Reference was made to outcome markers such as rate of discharge to home, 1-year disability and 1-year mortality. The rate of discharge progressively decreased with increase in mRS, while the rates of 1-year mortality and disability progressively increased. Our proposal is one of defining a stroke “minor” when the rate of discharge to home is above the SIRIO database overall value and the 1-year mortality and disability is below the respective overall values. This definition is consistent with a score ≤2 on the mRS. 相似文献
59.
Gutierrez M Luccioli F Salaffi F Bartoloni E Bertolazzi C Bini V Filipucci E Grassi W Gerli R 《Clinical rheumatology》2012,31(3):463-468
This study was conducted to determine the prevalence of subclinical entheseal involvement at the greater trochanter level
by ultrasound in patients with spondyloarthritis. Forty-six patients with spondyloarthritis and 46 healthy age- and sex-matched
controls were studied. All patients with no clinical evidence of enthesopathy at the greater trochanter underwent an ultrasound
examination. The following three entheses were scanned bilaterally: anterior insertion of gluteus minimus, anterior insertion
of gluteus medius, and posterior insertion of gluteus medius. Ultrasound findings of enthesopathy were thickening, calcifications,
bone erosions, enthesophytes, bursitis, and power Doppler signal. A total of 276 entheses were evaluated in spondyloarthritis
patients. In 112 out of 276 (40.5%), grayscale ultrasound found enthesopathy. The enthesis with the highest number of signs
of enthesopathy was the anterior insertion of gluteus medius (46/276) (16%), followed by posterior insertion of gluteus medius
(37/276) (13.4%) and anterior insertion of gluteus minimus (29/276) (10.5%). In the healthy population, ultrasound found entesopathy
in 80 out of 276 (29%) entheseal sites (p < 0.0001). Posterior insertion of gluteus medius enthesis was the more frequently involved (34/276) (12.3%), followed by
anterior insertion of gluteus medius (24/276) (8.6%) and anterior insertion of gluteus minimus (22/276) (7.9%). Power Doppler
was found more frequently in patients with spondyloarthritis compared with healthy controls (1% vs 0%). Our results show a
higher prevalence of subclinical enthesopathy at the greater trochanter level in patients with spondyloarthritis than in age-
and sex-matched healthy controls. 相似文献
60.
Visalli G Bertuccio MP Currò M Pellicanò G Sturniolo G Carnevali A Spataro P Ientile R Picerno I Cavallari V Piedimonte G 《AIDS research and human retroviruses》2012,28(9):1110-1118
Regressive morphological lesions, found in peripheral lymphocytes from HIV(+) patients, clearly conflict with normal cycle progression and with the execution of basic housekeeping and immune functions. With these lesions, circulating lymphocytes are destined to spontaneous and energy-independent cell lysis. By means of confocal microscopy and morphometry, we have quantified the rate of circulating T cells that are probably destined to emocatheresis in vivo. This rate includes lymphocytes in which nucleolin fragments have been scattered out of the nuclear region as a result of prelethal alterations in the nuclear membrane permeability. In terms of bioenergetics, these cells show evident anomalies in the energy production machinery that make them unable to carry out ATP-requiring functions. The extent of damaged cell fraction in peripheral blood reflects the frequency with which T lymphocytes leave lymphoid tissue to be cleared in hemocatheretic processes. 相似文献