全文获取类型
收费全文 | 105篇 |
免费 | 9篇 |
国内免费 | 4篇 |
专业分类
儿科学 | 1篇 |
基础医学 | 25篇 |
口腔科学 | 1篇 |
临床医学 | 6篇 |
内科学 | 32篇 |
皮肤病学 | 1篇 |
神经病学 | 12篇 |
特种医学 | 4篇 |
外科学 | 9篇 |
现状与发展 | 1篇 |
预防医学 | 5篇 |
药学 | 16篇 |
中国医学 | 1篇 |
肿瘤学 | 4篇 |
出版年
2024年 | 1篇 |
2023年 | 3篇 |
2022年 | 5篇 |
2021年 | 13篇 |
2020年 | 7篇 |
2019年 | 9篇 |
2018年 | 3篇 |
2017年 | 1篇 |
2016年 | 8篇 |
2015年 | 4篇 |
2014年 | 1篇 |
2013年 | 8篇 |
2012年 | 13篇 |
2011年 | 12篇 |
2010年 | 3篇 |
2009年 | 7篇 |
2008年 | 3篇 |
2007年 | 8篇 |
2006年 | 4篇 |
2004年 | 2篇 |
2003年 | 3篇 |
排序方式: 共有118条查询结果,搜索用时 15 毫秒
101.
102.
Chen CH Dickman KG Moriya M Zavadil J Sidorenko VS Edwards KL Gnatenko DV Wu L Turesky RJ Wu XR Pu YS Grollman AP 《Proceedings of the National Academy of Sciences of the United States of America》2012,109(21):8241-8246
Aristolochic acid, a potent human carcinogen produced by Aristolochia plants, is associated with urothelial carcinoma of the upper urinary tract (UUC). Following metabolic activation, aristolochic acid reacts with DNA to form aristolactam (AL)-DNA adducts. These lesions concentrate in the renal cortex, where they serve as a sensitive and specific biomarker of exposure, and are found also in the urothelium, where they give rise to a unique mutational signature in the TP53 tumor-suppressor gene. Using AL-DNA adducts and TP53 mutation spectra as biomarkers, we conducted a molecular epidemiologic study of UUC in Taiwan, where the incidence of UUC is the highest reported anywhere in the world and where Aristolochia herbal remedies have been used extensively for many years. Our study involves 151 UUC patients, with 25 patients with renal cell carcinomas serving as a control group. The TP53 mutational signature in patients with UUC, dominated by otherwise rare A:T to T:A transversions, is identical to that observed in UUC associated with Balkan endemic nephropathy, an environmental disease. Prominent TP53 mutational hotspots include the adenine bases of (5')AG (acceptor) splice sites located almost exclusively on the nontranscribed strand. A:T to T:A mutations also were detected at activating positions in the FGFR3 and HRAS oncogenes. AL-DNA adducts were present in the renal cortex of 83% of patients with A:T to T:A mutations in TP53, FGFR3, or HRAS. We conclude that exposure to aristolochic acid contributes significantly to the incidence of UUC in Taiwan, a finding with significant implications for global public health. 相似文献
103.
104.
Zhonghan Yang Viktoriya Grinchuk Allen Smith Bolin Qin Jennifer A. Bohl Rex Sun Luigi Notari Zhongyan Zhang Hiromi Sesaki Joseph F. Urban Jr. Terez Shea-Donohue Aiping Zhao 《Infection and immunity》2013,81(6):1905-1914
Obesity is associated with a chronic low-grade inflammation characterized by increased levels of proinflammatory cytokines that are implicated in disrupted metabolic homeostasis. Parasitic nematode infection induces a polarized Th2 cytokine response and has been explored to treat autoimmune diseases. We investigated the effects of nematode infection against obesity and the associated metabolic dysfunction. Infection of RIP2-Opa1KO mice or C57BL/6 mice fed a high-fat diet (HFD) with Nippostrongylus brasiliensis decreased weight gain and was associated with improved glucose metabolism. Infection of obese mice fed the HFD reduced body weight and adipose tissue mass, ameliorated hepatic steatosis associated with a decreased expression of key lipogenic enzymes/mediators, and improved glucose metabolism, accompanied by changes in the profile of metabolic hormones. The infection resulted in a phenotypic change in adipose tissue macrophages that was characterized by upregulation of alternative activation markers. Interleukin-13 (IL-13) activation of the STAT6 signaling pathway was required for the infection-induced attenuation of steatosis but not for improved glucose metabolism, whereas weight loss was attributed to both IL-13/STAT6-dependent and -independent mechanisms. Parasitic nematode infection has both preventive and therapeutic effects against the development of obesity and associated features of metabolic dysfunction in mice. 相似文献
105.
Tikunova N Dubrovskaya V Morozova V Yun T Khlusevich Y Bormotov N Laman A Brovko F Shvalov A Belanov E 《Virus research》2012,163(1):141-150
A panel of recombinant human antibodies to orthopoxviruses was isolated from a combinatorial phage display library of human scFv antibodies constructed from the Vh and Vl genes cloned from the peripheral blood lymphocytes of Vaccinia virus (VACV) immune donors. Plaque-reduction neutralization tests showed that seven selected phage-displaying scFv antibodies (pdAbs) neutralized both CPXV and VACV, and five of them neutralized Monkeypox virus (MPXV). Western blot analysis of VACV and CPXV proteins demonstrated that seven neutralizing antibodies recognized a 35 kDa protein. To identify this target protein, we produced a recombinant J3L protein of CPXV and showed that all the selected neutralizing antibodies recognized this protein. Neutralizing pdAb b9 was converted into fully human mAb b9 (fh b9), and scFv b9 displayed high binding affinities (Kd of 0.7 and 3.2 nM). The fh b9 reduced VACV plaque formation in a dose-dependent manner. 相似文献
106.
107.
Yeghiazaryan K Peeva V Shenoy A Schild HH Golubnitschaja O 《Infectious disorders drug targets》2011,11(2):188-195
108.
109.
Shin SS Mathew TA Yanova GV Fitzmaurice GM Livchits V Yanov SA Strelis AK Mishustin SP Bokhan NA Lastimoso CS Connery HS Hart JE Greenfield SF 《Central European journal of public health》2010,18(3):132-138
Drinking behavior among Russian women remains poorly described. We analyzed gender differences in alcohol use among 374 tuberculosis patients in Tomsk, Siberia. Twenty-six (28.3%) women had lifetime alcohol abuse or dependence, compared with 70.6% of men. Women with alcohol use disorders drank 12.7 +/- 14.0 standard drinks per day and > or = 34.6% drank 2 three days per week. Among individuals with a lifetime alcohol use disorder, age of onset and typical consumption did not differ significantly by gender. We conclude that Russian women with alcohol use disorders consume almost as much alcohol as men and may be at greater risk for negative social and medical consequences. 相似文献